Physical, physiological demands and movement profiles of elite men’s field hockey games

The aim of this study was to investigate physical demands, physiological demands, and movement profiles of different positions across four quarters in professional men’s field hockey games. Eighteen professional male field hockey players participated in the study, and data were collected in eleven official matches. Players wore global positioning system units and heart rate monitors to collect physical, physiological, and movement profile data. Defenders had significantly higher absolute total distance covered, player load, acceleration and deceleration count, and forward-backward initial movement analysis (IMA) count, but lower high speed running distance, compared with midfielders and forwards (p<.05). However, when using relative metrics (normalised by playing time), defenders had the lowest physical and physiological outputs, and forwards had the highest (p<.05). Total distance covered per minute, high-speed running distance per minute, player load per minute, acceleration and deceleration count per minute, and repeated high-intensity efforts per minute were all significantly higher in quarter 1 than in other three quarters (p<.05). The percentages of linear running and non-linear dynamic movement duration decreased quarter by quarter. Modified training impulse per minute reached its peak in quarter 2 (p<.05). It was concluded that defenders had the highest volume in terms of the game demands due to their high playing minutes; however, they had the lowest relative volume compared with the other two positions. Forwards had the highest linear running intensity, while midfielders were required to perform more multi-directional, non-linear movements. Quarter 1 was the most active quarter and players became fatigued in quarter 2. IMA counts were not sensitive to fatigue compared to movement profile and modified training impulse variables

El impacto del turismo el países subdesarrollados

El turismo es uno de los sectores más potentes para un país desarrollado y aporta numerosos beneficios. Sin embargo, para un país subdesarrollado supone una gran potencialidad para su economía y sociedad. El objetivo de este Trabajo de Fin de Grado es, mediante una investigación previa, realizar un análisis del impacto del turismo en los países subdesarrollados, utilizando ejemplos del mundo. Para abordar esta temática, se lleva a cabo un estudio en la conceptualización y la revisión de la literatura existente, que se ampliará con información proveniente de organizaciones de renombre y proyectos actuales. De esta manera, se podrán analizar los efectos de este sector en diversos ámbitos: económico, cultural, medioambiental, etc. A través de este proyecto se examina el tipo de dificultades y retos a los que se tienen que enfrentar los países, objeto de estudio, así como el tipo de oportunidades que se pueden generar. También se considera la importancia de la gestión y planificación sostenible del turismo, destacando la necesidad de estrategias y políticas que promuevan un turismo responsable. Por último, se estudia el turismo pro-pobre, cuyo objetivo es maximizar beneficios para las comunidades locales y lograr la inversión en la preservación de recursos.Grado en Turism

Alcohol Promotes Mammary Tumor Growth through Activation of VEGF-Dependent Tumor Angiogenesis

Alcohol consumption has been recognized as a risk factor for breast cancer. Experimental studies demonstrate that alcohol exposure promotes the progression of existing mammary tumors. However, the mechanisms underlying this effect remain unclear. In the present study, the role of vascular endothelial growth factor (VEGF) in alcohol promotion of breast cancer development was investigated using a mouse xenograft model of mammary tumors and a three-dimensional (3D) tumor/endothelial cell co-culture system. For the mouse xenograft model, mouse E0771 breast cancer cells were implanted into the mammary fat pad of C57BL6 mice. These mice were exposed to alcohol in their drinking water. For the 3D co-culture system, E0771 cells and MDA-MB231 breast cancer cells were co-cultured with SVEC4-10EE2 and human umbilical vein endothelial cells, respectively. The results demonstrated that alcohol increased tumor angiogenesis and accelerated tumor growth. Furthermore, it appeared that alcohol induced VEGF expression in breast cancer cells in vitro and in vivo. Blocking VEGF signaling by SU5416 inhibited tumor angiogenesis in the 3D tumor/endothelial cell co-culture system. Furthermore, injection of SU5416 into mice inhibited alcohol-promoted mammary tumor growth in vivo. These results indicate that alcohol may promote mammary tumor growth by stimulating VEGF-dependent angiogenesis

HI-Kyber: A novel high-performance implementation scheme of Kyber based on GPU

CRYSTALS-Kyber, as the only public key encryption (PKE) algorithm selected by the National Institute of Standards and Technology (NIST) in the third round, is considered one of the most promising post-quantum cryptography (PQC) schemes. Lattice-based cryptography uses complex discrete alogarithm problems on lattices to build secure encryption and decryption systems to resist attacks from quantum computing. Performance is an important bottleneck affecting the promotion of post quantum cryptography. In this paper, we present a High-performance Implementation of Kyber (named HI-Kyber) on the NVIDIA GPUs, which can increase the key-exchange performance of Kyber to the million-level. Firstly, we propose a lattice-based PQC implementation architecture based on kernel fusion, which can avoid redundant global-memory access operations. Secondly, We optimize and implement the core operations of CRYSTALS-Kyber, including Number Theoretic Transform (NTT), inverse NTT (INTT), pointwise multiplication, etc. Especially for the calculation bottleneck NTT operation, three novel methods are proposed to explore extreme performance: the sliced layer merging (SLM), the sliced depth-first search (SDFS-NTT) and the entire depth-first search (EDFS-NTT), which achieve a speedup of 7.5%, 28.5%, and 41.6% compared to the native implementation. Thirdly, we conduct comprehensive performance experiments with different parallel dimensions based on the above optimization. Finally, our key exchange performance reaches 1,664 kops/s. Specifically, based on the same platform, our HI-Kyber is 3.52$\times$ that of the GPU implementation based on the same instruction set and 1.78$\times$ that of the state-of-the-art one based on AI-accelerated tensor core

Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction

© 2019 American Chemical Society.We report a Michael-type cyanation reaction of coumarins by using CO2 as a catalyst. The delivery of the nucleophilic cyanide was realized by catalytic amounts of CO2, which forms cyanoformate and bicarbonate in the presence of water. Under ambient conditions, CO2-catalyzed reactions afforded high chemo- A nd diastereoselectivity of β-nitrile carbonyls, whereas only low reactivities were observed under argon or N2. Computational and experimental data suggest the catalytic role of CO2, which functions as a Lewis acid, and a protecting group to mask the reactivity of the product, suppressing byproducts and polymerization. The utility of this convenient method was demonstrated by preparing biologically relevant heterocyclic compounds with ease11sciescopu

Bile acid signalling and its role in anxiety disorders

Anxiety disorder is a prevalent neuropsychiatric disorder that afflicts 7.3%~28.0% of the world’s population. Bile acids are synthesized by hepatocytes and modulate metabolism via farnesoid X receptor (FXR), G protein-coupled receptor (TGR5), etc. These effects are not limited to the gastrointestinal tract but also extend to tissues and organs such as the brain, where they regulate emotional centers and nerves. A rise in serum bile acid levels can promote the interaction between central FXR and TGR5 across the blood-brain barrier or activate intestinal FXR and TGR5 to release fibroblast growth factor 19 (FGF19) and glucagon-like peptide-1 (GLP-1), respectively, which in turn, transmit signals to the brain via these indirect pathways. This review aimed to summarize advancements in the metabolism of bile acids and the physiological functions of their receptors in various tissues, with a specific focus on their regulatory roles in brain function. The contribution of bile acids to anxiety via sending signals to the brain via direct or indirect pathways was also discussed. Different bile acid ligands trigger distinct bile acid signaling cascades, producing diverse downstream effects, and these pathways may be involved in anxiety regulation. Future investigations from the perspective of bile acids are anticipated to lead to novel mechanistic insights and potential therapeutic targets for anxiety disorders

Mapping the Galactic disk with the LAMOST and Gaia Red clump sample: I: precise distances, masses, ages and 3D velocities of ∼\sim 140000 red clump stars

We present a sample of $\sim$ 140,000 primary red clump (RC) stars of spectral signal-to-noise ratios higher than 20 from the LAMOST Galactic spectroscopic surveys, selected based on their positions in the metallicity-dependent effective temperature--surface gravity and color--metallicity diagrams, supervised by high-quality $Kepler$ asteroseismology data. The stellar masses and ages of those stars are further determined from the LAMOST spectra, using the Kernel Principal Component Analysis method, trained with thousands of RCs in the LAMOST-$Kepler$ fields with accurate asteroseismic mass measurements. The purity and completeness of our primary RC sample are generally higher than 80 per cent. For the mass and age, a variety of tests show typical uncertainties of 15 and 30 per cent, respectively. Using over ten thousand primary RCs with accurate distance measurements from the parallaxes of Gaia DR2, we re-calibrate the $K_{\rm s}$ absolute magnitudes of primary RCs by, for the first time, considering both the metallicity and age dependencies. With the the new calibration, distances are derived for all the primary RCs, with a typical uncertainty of 5--10 per cent, even better than the values yielded by the Gaia parallax measurements for stars beyond 3--4 kpc. The sample covers a significant volume of the Galactic disk of $4 \leq R \leq 16$ kpc, $|Z| \leq 5$ kpc, and $-20 \leq \phi \leq 50^{\circ}$. Stellar atmospheric parameters, line-of-sight velocities and elemental abundances derived from the LAMOST spectra and proper motions of Gaia DR2 are also provided for the sample stars. Finally, the selection function of the sample is carefully evaluated in the color-magnitude plane for different sky areas. The sample is publicly available.Comment: 16 pages, 19 figures, 3 tables, accepted for publication in ApJ

The role of m6A demethylases in lung cancer: diagnostic and therapeutic implications

m6A is the most prevalent internal modification of eukaryotic mRNA, and plays a crucial role in tumorigenesis and various other biological processes. Lung cancer is a common primary malignant tumor of the lungs, which involves multiple factors in its occurrence and progression. Currently, only the demethylases FTO and ALKBH5 have been identified as associated with m6A modification. These demethylases play a crucial role in regulating the growth and invasion of lung cancer cells by removing methyl groups, thereby influencing stability and translation efficiency of mRNA. Furthermore, they participate in essential biological signaling pathways, making them potential targets for intervention in lung cancer treatment. Here we provides an overview of the involvement of m6A demethylase in lung cancer, as well as their potential application in the diagnosis, prognosis and treatment of the disease