Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

Drug nanosuspensions/nanocrystals have been recognized as one useful and successful approach for drug delivery. Drug nanocrystals could be further decorated to possess extended functions (such as controlled release) and designed for special in vivo applications (such as drug tracking), which make best use of the advantages of drug nanocrystals. A lot of novel and advanced size reduction methods have been invented recently for special drug deliveries. In addition, some novel downstream processes have been combined with nanosuspensions, which have highly broadened its application areas (such as targeting) besides traditional routes. A large number of recent research publication regarding as nanocrystals focuses on above mentioned aspects, which have widely attracted attention. This review will focus on the recent development of nanocrystals and give an overview of regarding modification of nanocrystal by some new approaches for tailor-made drug delivery

An sTGC Prototype Readout System for ATLAS New-Small-Wheel Upgrade

This paper presents a readout system designed for testing the prototype of Small-Strip Thin Gap Chamber (sTGC), which is one of the main detector technologies used for ATLAS New-Small-Wheel Upgrade. This readout system aims at testing one full-size sTGC quadruplet with cosmic muon triggers

Does Taking One Step Back Get You Two Steps Forward? Grade Retention and School Performance in Poor Areas in Rural China

Despite the rise in grade retention in poor areas in rural China recently, little work has been done to understand the impact of grade retention on the educational performance of students in these areas in rural China. This paper seeks to redress this shortcoming and examines the effect of grade retention on educational performance on 1649 students in 36 elementary schools in Shaanxi province. With a dataset that was collected from a survey designed specifically to capture school performance of students before and after they were retained, we use Differences-in-Differences, Propensity Score Matching and Differences-in-Differences Matching approaches to analyze the effect of grade retention on school performance. Although the descriptive analysis shows that grade retention helps to improve the scores of the students that were retained, somewhat surprisingly, the results from the multivariate analysis consistently show that there is no significant positive effect of grade retention on school performance of the students. In fact, in some cases (e.g., for the students who repeat grade 2), grade retention is shown to hurt school performance.

Optimized fringe removal algorithm for absorption images

Optical absorption imaging is a basic detection technique for obtaining information from matter waves, in which the absorption signal can be obtained by comparing the recorded detection light field with the light field in the presence of absorption, thereby giving the spatial distribution of the atoms. The noise in detection arises mainly from differences between the two recorded light field distributions, which is difficult to avoid in experiments. In this work, we present an optimized fringe removal algorithm, developing a method to generate an ideal reference light field, avoiding the noise generated by the light field difference, and suppressing the noise signal to the theoretical limit. Using principal component analysis, we explore the optimal calculation area and how to remove noise information from the basis to allow optimal performance and speed. As an example, we consider scattering atomic peaks with a small number of atoms in a triangular lattice. Compared with the conventional processing method, our algorithm can reduce the measured atomic temperature variance by more than three times, giving a more reliable result.Comment: 5 pages, 4 figures, accepted by AP