1,618 research outputs found
NNLO QCD Corrections to t-channel Single Top-Quark Production and Decay
We present a fully differential next-to-next-to-leading order calculation of
t-channel single top-quark production and decay at the LHC under narrow-width
approximation and neglecting cross-talk between incoming protons. We focus on
the fiducial cross sections at 13 TeV, finding that the next-to-next-to-leading
order QCD corrections can reach the level of -6%. The scale variations are
reduced to the level of a percent. Our results can be used to improve
experimental acceptance estimates and the measurements of the single top-quark
production cross section and the top-quark electroweak couplings.Comment: 6 pages, 4 figures, version appear on PRD rapid communicatio
Pure spin current in a two-dimensional topological insulator
We predict a mechanism to generate a pure spin current in a two-dimensional
topological insulator. As the magnetic impurities exist on one of edges of the
two-dimensional topological insulator, a gap is opened in the corresponding
gapless edge states but another pair of gapless edge states with opposite spin
are still protected by the time-reversal symmetry. So the conductance plateaus
with the half-integer values can be obtained in the gap induced by
magnetic impurities, which means that the pure spin current can be induced in
the sample. We also find that the pure spin current is insensitive to weak
disorder. The mechanism to generate pure spin currents is generalized for
two-dimensional topological insulators.Comment: 5 pages, 6 figure
Identification Of A Novel Domain At The N Terminus Of Caveolin-1 That Controls Rear Polarization Of The Protein And Caveolae Formation
Diazotroph abundance and community structure are reshaped by straw return and mineral fertilizer in rice-rice-green manure rotation
(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.
Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such, selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently, we have identified an effective analogue of resveratrol, (Z)3,4,5,4′-trans-tetramethoxystilbene (TMS) which selectively elevated the intracellular calcium level in gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. TMS exhibited significant inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR were inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum (ER) stress and AMPK activation. Proteomics analysis also further confirmed that mTOR pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together, TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients
Correlations in Two-Dimensional Vortex Liquids
We report on a high temperature perturbation expansion study of the
superfluid-density spatial correlation function of a Ginzburg-Landau-model
superconducting film in a magnetic field. We have derived a closed form which
expresses the contribution to the correlation function from each graph of the
perturbation theory in terms of the number of Euler paths around appropriate
subgraphs. We have enumerated all graphs appearing out to 10-th order in the
expansion and have evaluated their contributions to the correlation function.
Low temperature correlation functions, obtained using Pad\'{e} approximants,
are in good agreement with Monte Carlo simulation results and show that the
vortex-liquid becomes strongly correlated at temperatures well above the vortex
solidification temperature.Comment: 18 pages (RevTeX 3.0) and 4 figures, available upon request,
IUCM93-01
Two-Dimensional Vortex Lattice Melting
We report on a Monte-Carlo study of two-dimensional Ginzburg-Landau
superconductors in a magnetic field which finds clear evidence for a
first-order phase transition characterized by broken translational symmetry of
the superfluid density. A key aspect of our study is the introduction of a
quantity proportional to the Fourier transform of the superfluid density which
can be sampled efficiently in Landau gauge Monte-Carlo simulations and which
satisfies a useful sum rule. We estimate the latent heat per vortex of the
melting transition to be where is the melting
temperature.Comment: 10 pages (4 figures available on request), RevTex 3.0, IUCM93-00
Big, Fast Vortices in the d-RVB theory of High Temperature Superconductivity
The effect of proximity to a Mott insulating phase on the superflow
properties of a d-wave superconductor is studied using the slave boson-U(1)
gauge theory model. The model has two limits corresponding to superconductivity
emerging either out of a 'renormalized fermi liquid' or out of a
non-fermi-liquid regime. Three crucial physical parameters are identified: the
size of the vortex \textit{as determined from the supercurrent it induces;} the
coupling of the superflow to the quasiparticles and the 'nondissipative time
derivative' term. As the Mott phase is approached, the core size as defined
from the supercurrent diverges, the coupling between superflow and
quasiparticles vanishes, and the magnitude of the nondissipative time
derivative dramatically increases. The dissipation due to a moving vortex is
found to vary as the third power of the doping. The upper critical field and
the size of the critical regime in which paraconductivity may be observed are
estimated, and found to be controlled by the supercurrent length scale
Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation
Drug resistance is a growing problem that necessitates new strategies to combat pathogens. Neutrophil phagocytosis and production of intracellular ROS, in particular, has been shown to cooperate with antibiotics in the killing of microbes. This study tested the hypothesis that p85α, the regulatory subunit of PI3K, regulates production of intracellular ROS. Genetic knockout of p85α in mice caused decreased expression of catalytic subunits p110α, p110β, and p110δ, but did not change expression levels of the NADPH oxidase complex subunits p67phox, p47phox, and p40phox. When p85α, p55α, and p50α (all encoded by Pik3r1) were deleted, there was an increase in intracellular ROS with no change in phagocytosis in response to both Fcγ receptor and complement receptor stimulation. Furthermore, the increased intracellular ROS correlated with significantly improved neutrophil killing of both methicillin-susceptible and methicillin-resistant S. aureus. Our findings suggest inhibition of p85α as novel approach to improving the clearance of resistant pathogens
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