Automatic 2D to Stereoscopic Video Conversion for 3DTV

In this thesis we address the problem of automatically converting a video filmed with a single camera to stereoscopic content tailored for viewing using 3D TVs. We present two techniques: (a) a non-parametric approach which does not require extensive training and produces good results for simple rigid scenes and, (b) a deep learning approach able to handle dynamic changes in the scene. The proposed solutions both include two stages: depth generation and rendering. For the first stage, for the non-parametric approach we utilize an energy-based optimization, and for the deep learning approach a multi-scale convolutional neural network to address the complex problem of depth estimation from a single image. Depth maps are generated based on the input RGB images. We reformulate and simplify the process of generating the virtual camera’s depth map and present how this can be used to render an anaglyph image. Anaglyph stereo was used for demonstration only because of the easy and wide availability of red/cyan glasses however, this does not limit the applicability of the proposed technique to other stereo forms. Finally, we have extensively tested the proposed approaches and present the results

Gas-Liquid Phenomena With Dynamic Contact Angles In The Cathode Of A Parallel Proton Exchange Membrane Fuel Cell

Among the numerical studies on liquid water transport in Proton Exchange Membrane Fuel Cells (PEMFCs), the static contact angle (SCA) model is generally used, while the dynamic contact angle (DCA) model is only applied on the simulation of droplet behaviors with simple geometries like a single microchannel. In this study, the DCA model is employed to study the gas-liquid phenomena inside the cathode of PEMFC with parallel flow field design, i.e., Parallel-DCA model. The water emerging and transport processes are simulated based on this Parallel-DCA model using the volume of fluid (VOF) method. The numerical results are also compared to those from the Parallel-SCA model with the same computational domain and operating conditions

The response of sea ice and high-salinity shelf water in the Ross Ice Shelf Polynya to cyclonic atmosphere circulations

Coastal polynyas in the Ross Sea are important source regions of high-salinity shelf water (HSSW) - the precursor of Antarctic Bottom Water thatsupplies the lower limb of the thermohaline circulation. Here, the responseof sea ice production and HSSW formation to synoptic-scale and mesoscalecyclones was investigated for the Ross Ice Shelf Polynya (RISP) using acoupled ocean-sea ice-ice shelf model targeted on the Ross Sea. Whensynoptic-scale cyclones prevailed over RISP, sea ice production (SIP)increased rapidly by 20 %-30 % over the entire RISP. During the passage of mesoscale cyclones, SIP increased by about 2 times over the western RISP but decreased over the eastern RISP, resulting respectively from enhancement inthe offshore and onshore winds. HSSW formation mainly occurred in thewestern RISP and was enhanced responding to the SIP increase under bothtypes of cyclones. Promoted HSSW formation could persist for 12-60 h after the decay of the cyclones. The HSSW exports across the DrygalskiTrough and the Glomar Challenger Trough were positively correlated with themeridional wind. Such correlations are mainly controlled by variations ingeostrophic ocean currents that result from sea surface elevation change and density differences.Peer reviewe

Numerical Simulation Of Gas-Liquid Phenomena In The Cathode Of A Stirred Tank Reactor Proton Exchange Membrane Fuel Cell

Liquid water management is still a critical issue in the improvement of proton exchange membrane fuel cell (PEMFC) performance. In this work, for the first time, the liquid water behavior and transport inside the cathode of a PEMFC with a stirred tank reactor (STR) design, rather than the conventional PEMFC flow channel design, are numerically studied. The volume of fluid (VOF) method is employed in the simulation to track the gas-liquid interface. The capability of STR-PEMFC to reduce the liquid water flooding is also investigated and verified from the simulation, showing the potential of this channel-less type fuel cell in the further development

Evidence for Large-Scale Climate Forcing of Dense Shelf Water Variability in the Ross Sea

Antarctic Bottom Water (AABW), which supplies the lower limb of the thermohaline circulation, originates from dense shelf water (DSW) forming in Antarctic polynyas. Here, combining a long mooring record of DSW measurements with numerical simulations and satellite data, we show that significant correlation exists between interannual variability of DSW production in the Ross Sea polynyas, where DSW contributes between 20-40% of the global AABW production, and the Southern Annular Mode (SAM). The correlation is largest when the Amundsen Sea Low (ASL) is weakened and shifted east of the Ross Sea. During positive SAM phases, enhanced offshore winds and lower air temperatures over the western Ross Sea increase sea ice production and promote DSW formation, with the opposite response during negative SAM phases. These processes ultimately modulate AABW thickness in the open ocean. A projected positive shift of the SAM and eastward displacement of the ASL thus has implications for the future of DSW and AABW formation

TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase

Acute lung injury (ALI) is the leading cause of morbidity and mortality in critically ill patients. Neutrophil extracellular traps (NETs) have been well documented in the ALI model of bacterial infection. In the present study, we demonstrated that poly I:C could induce pulmonary NETs. Upon poly I:C intratracheal inoculation, neutrophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly increased. Furthermore, the inflammatory cytokines IL-1β, IL-6, and TNF-α in the lung were also significantly elevated. Neutrophil depletion abolished NETs and decreased both neutrophil infiltration and IL-1β in the lung. As expected, DNase I, an inhibitor of MPO and NADPH, decreased pulmonary inflammation and NETs. Blocking of the poly I:C receptor TLR3 reduced lung inflammation and NETs. The MAPK kinase inhibitor p38 diminished the formation of NETs and restored the expression of the tight junction protein claudin-5 in the mouse lung when challenged with poly I:C. In summary, poly I:C induced the formation of pulmonary NETs and ALI, which may be associated with the activation of p38 MAPK and the decreased expression of claudin-5

Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke

Transcranial magnetic stimulation (TMS) is a non-invasive brain neurostimulation technique that can be used as one of the adjunctive treatment techniques for neurological recovery after stroke. Animal studies have shown that TMS treatment of rats with middle cerebral artery occlusion (MCAO) model reduced cerebral infarct volume and improved neurological dysfunction in model rats. In addition, clinical case reports have also shown that TMS treatment has positive neuroprotective effects in stroke patients, improving a variety of post-stroke neurological deficits such as motor function, swallowing, cognitive function, speech function, central post-stroke pain, spasticity, and other post-stroke sequelae. However, even though numerous studies have shown a neuroprotective effect of TMS in stroke patients, its possible neuroprotective mechanism is not clear. Therefore, in this review, we describe the potential mechanisms of TMS to improve neurological function in terms of neurogenesis, angiogenesis, anti-inflammation, antioxidant, and anti-apoptosis, and provide insight into the current clinical application of TMS in multiple neurological dysfunctions in stroke. Finally, some of the current challenges faced by TMS are summarized and some suggestions for its future research directions are made

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

SummaryWe identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence and absence of drugs with corresponding whole-genome transcriptome sequencing. RORγt acts as a direct activator of Th17 cell signature genes and a direct repressor of signature genes from other T cell lineages; its strongest transcriptional effects are on cis-regulatory sites containing the RORα binding motif. RORγt is central in a densely interconnected regulatory network that shapes the balance of T cell differentiation. Here, the three inhibitors modulated the RORγt-dependent transcriptional network to varying extents and through distinct mechanisms. Whereas one inhibitor displaced RORγt from its target loci, the other two inhibitors affected transcription predominantly without removing DNA binding. Our work illustrates the power of a system-scale analysis of transcriptional regulation to characterize potential therapeutic compounds that inhibit pathogenic Th17 cells and suppress autoimmunity

Generation of integration-free neural progenitor cells from cells in human urine

Human neural stem cells hold great promise for research and therapy in neural disease. We describe the generation of integration-free and expandable human neural progenitor cells (NPCs). We combined an episomal system to deliver reprogramming factors with a chemically defined culture medium to reprogram epithelial-like cells from human urine into NPCs (hUiNPCs). These transgene-free hUiNPCs can self-renew and can differentiate into multiple functional neuronal subtypes and glial cells in vitro. Although functional in vivo analysis is still needed, we report that the cells survive and differentiate upon transplant into newborn rat brain.postprin