An all fiber source of frequency entangled photon pairs

We present an all fiber source of frequency entangled photon pairs by using four wave mixing in a Sagnac fiber loop. Special care is taken to suppress the impurity of the frequency entanglement by cooling the fiber and by matching the polarization modes of the photon pairs counter-propagating in the fiber loop. Coincidence detection of signal and idler photons, which are created in pair and in different spatial modes of the fiber loop, shows the quantum interference in the form of spatial beating, while the single counts of the individual signal (idler) photons keep constant. When the production rate of photon pairs is about 0.013 pairs/pulse, the envelope of the quantum interference reveals a visibility of $(95\pm 2)$, which is close to the calculated theoretical limit 97.4%Comment: 11 pages, 6 figures, to appear in Phys. Rev.

Tropomyosin Period 3 Is Essential for Enhancement of Isometric Tension in Thin Filament-Reconstituted Bovine Myocardium

Tropomyosin (Tm) consists of 7 quasiequivalent repeats known as “periods,” and its specific function may be associated with these periods. To test the hypothesis that either period 2 or 3 promotes force generation by inducing a positive allosteric effect on actin, we reconstituted the thin filament with mutant Tm in which either period 2 (Δ2Tm) or period 3 (Δ3Tm) was deleted. We then studied: isometric tension, stiffness, 6 kinetic constants, and the pCa-tension relationship. N-terminal acetylation of Tm did not cause any differences. The isometric tension in Δ2Tm remained unchanged, and was reduced to ∼60% in Δ3Tm. Although the kinetic constants underwent small changes, the occupancy of strongly attached cross-bridges was not much different. The Hill factor (cooperativity) did not differ significantly between Δ2Tm (1.79 ± 0.19) and the control (1.73 ± 0.21), or Δ3Tm (1.35 ± 0.22) and the control. In contrast, pCa50 decreased slightly in Δ2Tm (5.11 ± 0.07), and increased significantly in Δ3Tm (5.57 ± 0.09) compared to the control (5.28 ± 0.04). These results demonstrate that, when ions are present at physiological concentrations in the muscle fiber system, period 3 (but not period 2) is essential for the positive allosteric effect that enhances the interaction between actin and myosin, and increases isometric force of each cross-bridge

Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma.

Background:DNA methylation of CpG sites on genetic loci has been linked to increased risk of asthma in children exposed to elevated ambient air pollutants (AAPs). Further identification of specific CpG sites and the pollutants that are associated with methylation of these CpG sites in immune cells could impact our understanding of asthma pathophysiology. In this study, we sought to identify some CpG sites in specific genes that could be associated with asthma regulation (Foxp3 and IL10) and to identify the different AAPs for which exposure prior to the blood draw is linked to methylation levels at these sites. We recruited subjects from Fresno, California, an area known for high levels of AAPs. Blood samples and responses to questionnaires were obtained (n = 188), and in a subset of subjects (n = 33), repeat samples were collected 2 years later. Average measures of AAPs were obtained for 1, 15, 30, 90, 180, and 365 days prior to each blood draw to estimate the short-term vs. long-term effects of the AAP exposures. Results:Asthma was significantly associated with higher differentially methylated regions (DMRs) of the Foxp3 promoter region (p = 0.030) and the IL10 intronic region (p = 0.026). Additionally, at the 90-day time period (90 days prior to the blood draw), Foxp3 methylation was positively associated with NO2, CO, and PM2.5 exposures (p = 0.001, p = 0.001, and p = 0.012, respectively). In the subset of subjects retested 2 years later (n = 33), a positive association between AAP exposure and methylation was sustained. There was also a negative correlation between the average Foxp3 methylation of the promoter region and activated Treg levels (p = 0.039) and a positive correlation between the average IL10 methylation of region 3 of intron 4 and IL10 cytokine expression (p = 0.030). Conclusions:Short-term and long-term exposures to high levels of CO, NO2, and PM2.5 were associated with alterations in differentially methylated regions of Foxp3. IL10 methylation showed a similar trend. For any given individual, these changes tend to be sustained over time. In addition, asthma was associated with higher differentially methylated regions of Foxp3 and IL10

An investigation on nitrogen uptake and microstructure of equimolar quaternary FeCoNiCr high entropy alloy after active-screen plasma nitriding

Under nitrogen diffusion treatments, N-expanded austenite (γN) can form at the surface of self-passivating Fe-Cr, Ni-Cr, and Co-Cr alloys at low temperatures, which provides beneficial hardening and enhancements in wear resistance without reducing corrosion resistance. Given the wide research interests in multicomponent equimolar alloys, an equimolar quaternary FeCoNiCr high entropy alloy (HEA) was investigated after active-screen plasma nitriding at 430–480 °C in this study. Firstly, the formation of γN-FeCoNiCr case at 430 °C was demonstrated with the bright case appearance after metallographic etching, the lattice expansion under XRD, the FCC electron diffraction patterns and the shear bands under TEM. Secondly, the thick treatment cases at ∼9–16 μm first indicated that N interstitial diffusion was not sluggish in the FeCoNiCr surface. Thirdly, analogous to stainless steels, the onset of dark regions in the etched γN-FeCoNiCr case was owing to the formation of a cellular mixture of CrN + γ-(Fe, Co, Ni) nano-lamellae at elevated treatment temperatures. The residual bright regions in γN-FeCoNiCr at 480 °C showed ∼1–3 nm CrN nanoprecipitates with no substantial Cr segregation. Additionally, a significant nanocrystalline layer was seen at the topmost surface at 480 °C, which is most likely associated with the high substrate Cr content

Development of MnO\u3csub\u3e2\u3c/sub\u3e cathode inks for flexographically printed rechargeable zinc-based battery

A novel roll-to-roll flexographic printing process for rechargeable zinc-based battery manufacturing was presented in this paper. Based on the fundamental operating mechanism of flexography, key criteria for developing functional flexographic printing inks were established, including composite ink rheology (steady-state viscosity and yield stress), ink wettability as well as ink dispersing qualities. A variety of MnO2 cathode inks were developed and analyzed comprehensively based on these criteria. A novel type of aqueous cathode ink based on PSBR polymeric binder showed excellent flexographic printability as well as promising electrochemical performance

Vitamin D and the brain: key questions for future research

Over the last decade a convergent body of evidence has emerged from epidemiology, animal experiments and clinical trials which links low vitamin D status with a range of adverse neuropsychiatric outcomes. This research demonstrates that the timing of exposure to low vitamin D influences the nature of brain phenotypes, as exposures during gestation versus adulthood result in different phenotypes. With respect to early life exposures, there is robust evidence from rodent experiments indicating that transient developmental vitamin D (DVD) deficiency is associated with changes in brain structure, neurochemistry, gene and protein expression and behavior. In particular, DVD deficiency is associated with alterations in the dopaminergic neurotransmitter systems. In contrast, recently published animal experiments indicate that adult vitamin D (AVD) deficiency is associated with more subtle neurochemical and behavioral phenotypes. This paper explores key issues that need to be addressed in future research. There is a need to define the timing and duration of the ‘critical window’ during which low vitamin D status is associated with differential and adverse brain outcomes. We discuss the role for ‘two-hit hypotheses’, which propose that adult vitamin D deficiency leaves the brain more vulnerable to secondary adverse exposures, and thus may exacerbate disease progression. Finally, we explore the evidence implicating a role for vitamin D in rapid, non-genomic mechanisms that may involve L-type calcium channels and brain functio

Superior efficacy of a human immunodeficiency virus vaccine combined with antiretroviral prevention in simian-human immunodeficiency virus-challenged nonhuman primates

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