Effect of Corrosion and Corrosion Rate on the Mechanical Performance of Carbon and Stainless Steel Reinforcing Bars

Steel corrosion is a predominant factor leading to age-related structural degradation. To understand the different effects of pitting corrosion on the mechanical performances of deformed carbon and stainless steel reinforcing bars, an artificially accelerated method was conducted to corrode the steel bars. Using a 3D laser scanner, the three-dimensional models of corroded steel bars were reconstructed. The corrosion characterization was identified based on these 3D profiles. The results indicate that the number and the depth of corrosion pits of both types of steel increase with the increase of corrosion rate, however the pitting corrosion of stainless steel is much more obvious than the carbon steel. Axial tensile tests of corroded carbon and stainless steel bars were carried out. The tensile test results show that both the yield and ultimate loads linearly decreased with an increase of corrosion loss while the ductility decreased correspondingly. With the increase of corrosion loss, brittle fracture gradually occurred in the corroded carbon steel bars at the location of critical cross-sectional area. However, the degradation ratio of elongation of stainless steel is less than that of the carbon steel

Towards a Probabilistic Complexity-theoretic Modeling of Biological Cyanide Poisoning as Service Attack in Self-organizing Networks

We draw an analogy of \emph{biological cyanide poisoning} to security attacks in self-organizing mobile ad hoc networks. When a circulatory system is treated as an enclosed network space, a hemoglobin is treated as a mobile node, and a hemoglobin binding with cyanide ion is treated as a compromised node (which cannot bind with oxygen to furnish its oxygen-transport function), we show how cyanide poisoning can reduce the probability of oxygen/message delivery to a rigorously defined ``negligible\u27\u27 quantity. Like formal cryptography, security problem in our network-centric model is defined on the complexity-theoretic concept of ``negligible\u27\u27, which is asymptotically sub-polynomial with respect to a pre-defined system parameter $x$. Intuitively, the parameter $x$ is the key length $n$ in formal cryptography, but is changed to the network scale, or the number of network nodes $N$, in our model. We use the \RP ($n$-runs) complexity class with a virtual oracle to formally model the cyanide poisoning phenomenon and similar network threats. This new analytic approach leads to a new view of biological threats from the perspective of network security and complexity theoretic study

An Introduction to String Re-Writing Kernel

Abstract Learning for sentence re-writing is a fundamental task in natural language processing and information retrieval. In this paper, we propose a new class of kernel functions, referred to as string rewriting kernel, to address the problem. A string re-writing kernel measures the similarity between two pairs of strings. It can capture the lexical and structural similarity between sentence pairs without the need of constructing syntactic trees. We further propose an instance of string re-writing kernel which can be computed efficiently. Experimental results on benchmark datasets show that our method can achieve comparable results with state-of-the-art methods on two sentence re-writing learning tasks: paraphrase identification and recognizing textual entailment

A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses

Fundamental aspects of human behavior operate outside of conscious awareness. Yet, theories of conditioned responses in humans, such as placebo and nocebo effects on pain, have a strong emphasis on conscious recognition of contextual cues that trigger the response. Here, we investigated the neural pathways involved in nonconscious activation of conditioned pain responses, using functional magnetic resonance imaging in healthy participants. Nonconscious compared with conscious activation of conditioned placebo analgesia was associated with increased activation of the orbitofrontal cortex, a structure with direct connections to affective brain regions and basic reward processing. During nonconscious nocebo, there was increased activation of the thalamus, amygdala, and hippocampus. In contrast to previous assumptions about conditioning in humans, our results show that conditioned pain responses can be elicited independently of conscious awareness and our results suggest a hierarchical activation of neural pathways for nonconscious and conscious conditioned responses. Demonstrating that the human brain has a nonconscious mechanism for responding to conditioned cues has major implications for the role of associative learning in behavioral medicine and psychiatry. Our results may also open up for novel approaches to translational animal-to-human research since human consciousness and animal cognition is an inherent paradox in all behavioral science

MiR-574-5p Activates Human TLR8 to Promote Autoimmune Signaling and Lupus

Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus patients, with its expression levels correlating with the disease activity. miR-574-5p binds to and activates human hTLR8 or its murine ortholog mTlr7 to elicit a series of MyD88-dependent immune and inflammatory responses. These responses include the overproduction of cytokines and interferons, the activation of STAT1 signaling and B lymphocytes, and the production of autoantigens. In a transgenic mouse model, the induction of miR-574-5p overexpression is associated with increased secretion of antinuclear and anti-dsDNA antibodies, increased IgG and C3 deposit in the kidney, elevated expression of inflammatory genes in the spleen. In lupus-prone mice, lentivirus-mediated silencing of miR-574-5p significantly ameliorates major symptoms associated with lupus and lupus nephritis. Collectively, these results suggest that the miR-574-5p-hTLR8/mTlr7 signaling is an important axis of immune and inflammatory responses, contributing significantly to the development of lupus and lupus nephritis

The contribution of genetic risk and lifestyle factors in the development of adult-onset inflammatory bowel disease: a prospective cohort study

INTRODUCTION: The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. METHODS: Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into high, intermediate, and low genetic risk categories. Weighted healthy lifestyle scores were constructed based on 5 common lifestyle factors and categorized into favorable (4 or 5 healthy lifestyle factors), intermediate (3 healthy lifestyle factors), and unfavorable (0-2 healthy lifestyle factors) groups. Cox proportional hazards regression model was used to estimate the hazard ratios (HR) and 95% confidence interval (CI) for their associations. RESULTS: During the 12-year follow-up, 707 cases with CD and 1576 cases with UC were diagnosed in the UK Biobank cohort. Genetic risk and unhealthy lifestyle categories were monotonically associated with CD and UC risk with no multiplicative interaction between them. The HR of CD and UC were 2.24 (95% CI 1.75-2.86) and 2.15 (95% CI 1.82-2.53) for those with a high genetic risk, respectively. The HR of CD and UC for individuals with an unfavorable lifestyle were 1.94 (95% CI 1.61-2.33) and 1.98 (95% CI 1.73-2.27), respectively. The HR of individuals with a high genetic risk but a favorable lifestyle (2.33, 95% CI 1.58-3.44 for CD, and 2.05, 95% CI 1.58-2.66 for UC) were reduced nearly by half, compared with those with a high genetic risk but an unfavorable lifestyle (4.40, 95% CI 2.91-6.66 for CD and 4.44, 95% CI 3.34-5.91 for UC). DISCUSSION: Genetic and lifestyle factors were independently associated with susceptibility to incident CD and UC. Adherence to a favorable lifestyle was associated with a nearly 50% lower risk of CD and UC among participants at a high genetic risk