218 research outputs found
On the Translation Strategies of Human-computer Interaction Based on Machine Translation
With the rapid development of language service industry and artificial intelligence technology, machine translation plays a more prominent role in the translation industry. Human-computer interaction translation greatly improves the speed and quality of translation, and pre-translation editing and post-translation editing are two important links and manifestations in human-computer interaction collaborative translation. On the basis of summarizing machine translation problems, this paper proposes translation strategies including replacing well-translated terms in advance, rewriting, addition, omission, and shift via pre-editing and post-editing, which greatly improves the quality of machine translation
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Crif1 Promotes Osteoporosis in Mice after Radiation
Abstract Radiation induces rapid bone loss and enhances bone resorption and RANKL expression. RANKL provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption. However, the mechanisms of radiation-induced osteoporosis are not fully understood. Here, we show that Crif1 expression increases in bone marrow cells after radiation. Conditional Crif1 deletion in bone marrow cells causes decreases in RANKL expression and the RANKL/OPG ratio, and relieves bone loss after radiation in mice. We further demonstrated in vitro that Crif1 promotes RANKL secretion via the cAMP/PKA pathway. Moreover, protein-protein docking screening identified five compounds as Crif1 inhibitors; these compounds dramatically suppressed RANKL secretion and CREB phosphorylation when cells were exposed to forskolin. This study enriches current knowledge of the pathogenesis of osteoporosis and provides insights into potential therapeutic strategies for osteoporosis treatment
4-[Bis(1H-indol-3-yl)methyl]benzonitrile
In the title molecule, C24H17N3, the didhedral angles formed by the mean planes of the indole ring systems and the benzene ring are 86.44 (7) and 86.96 (7)°. The dihedral angle between the two indole ring systems is 72.08 (6)°. In the crystal, intermolecular bifurcated (N—H)2⋯N hydrogen bonds link molecules into sheets lying parallel to (010)
Establishment of a HEK293T cell line able to site-specifically integrate and stably express GDNF by rAAV-2 vector
Background: Using recombinant adeno-associated virus 2 (rAAV-2), we
attempted to establish a HEK293T cell line that is able to
site-specifically integrate and stably express glial cell line-derived
neurotrophic factor (GDNF). Results: Recombinant vector with enhanced
green fluorescent protein (EGFP) and GDNF (pTR-P5-EGFP-IRES-GDNF), as
well as that carrying Rep genes and SV40 promoters (pSVAV2) were
constructed and packed. HEK293T cells were co-infected with
rAAV-2/EGFP-GDNF and rAAV-2/SVAV2 virus separately at 1
7 104, 1
7 105, and 1
7 106 of multiplicity of infection (MOI). The
efficiency of transduction was detected using flow cytometry.
Additionally, the infected HEK293T cells were separately validated by
touchdown polymerase chain reaction (PCR) and Western-blot. After 72 h
of transduction, the rate of EGFP positive cell was 22%, 45% and 49% at
the MOIs of 1
7 104, 1
7 105 and 1
7 106, respectively.
On the 3rd, 6th and 9th day of cell passage, there was no significant
difference in the cell viability and proliferation rate between
transduction and control groups. Importantly, touchdown PCR showed that
there was a specific PCR amplified product band in the lane of infected
cells. Furthermore, GDNF expression was detected in the infected cells
after 15 and 180 d of cultivation. Conclusions: A HEK293T cell line
able to site-specifically integrate and stably express GDNF was
established
Vertical patterns of chlorophyll a in the euphotic layer are related to mesoscale eddies in the South China Sea
Phytoplankton closely connects with the hydrodynamics and biogeochemical environment of the ocean. While research focusing on both the physiochemical factors and hydrodynamics regulating phytoplankton has already been conducted, the coupling mechanism between mesoscale eddies and the vertical distribution of phyto plankton in the South China Sea (SCS) is still not well understood. Here, phytoplankton was studied under one weak-cold and two warm eddies along the 18°N transect in the SCS. The results show that the vertical distribution of chlorophyll (chl-a) presented a similar pattern at all four sampling stations. The mixed layer is less than 50 m. It is the same as the meridional salinity gradients that may be distinguished above a depth of 60 m. The subsurface chlorophyll maximum at the edge of a warm (WI) and cold eddy (CI) at E413 and E411 was shallower than that at the edge of a warm eddy (WII) at E407 and E409, indicating that temperature and salinity may be the important driving factors. On the whole, mesoscale eddies had a significant influence on the vertical pattern of chl-a in the SCS during the study period
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