143 research outputs found
Photonic Memristor for Future Computing: A Perspective
Photonic computing and neuromorphic computing could address the inherent limitations of traditional von Neumann architecture and gradually invalidate Moore’s law. As photonics applications are capable of storing and processing data in an optical manner with unprecedented bandwidth and high speed, twoâ terminal photonic memristors with a remote optical control of resistive switching behaviors at defined wavelengths ensure the benefit of onâ chip integration, low power consumption, multilevel data storage, and a large variation margin, suggesting promising advantages for both photonic and neuromorphic computing. Herein, the development of photonic memristors is reviewed, as well as their application in photonic computing and emulation on optogeneticsâ modulated artificial synapses. Different photoactive materials acting as both photosensing and storage media are discussed in terms of their opticalâ tunable memory behaviors and underlying resistive switching mechanism with consideration of photogating and photovoltaic effects. Moreover, lightâ involved logic operations, systemâ level integration, and lightâ controlled artificial synaptic memristors along with improved learning tasks performance are presented. Furthermore, the challenges in the field are discussed, such as the lack of a comprehensive understanding of microscopic mechanisms under light illumination and a general constraint of inferior nearâ infrared (NIR) sensitivity.The development of photonic memristors and their application in photonic computing and emulation on optogeneticsâ modulated artificial synapses are reviewed. Photoactive materials as photosensing and storage media are discussed, considering their opticalâ tunable memory behavior and resistive switching mechanism including photogating and photovoltaic effect. Lightâ involved logic operations, system level integration, and artificial synaptic memristors along with improved learning tasks performance are presented.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153103/1/adom201900766.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153103/2/adom201900766_am.pd
Spiral Complete Coverage Path Planning Based on Conformal Slit Mapping in Multi-connected Domains
Generating a smooth and shorter spiral complete coverage path in a
multi-connected domain is an important research area in robotic cavity
machining. Traditional spiral path planning methods in multi-connected domains
involve a subregion division procedure; a deformed spiral path is incorporated
within each subregion, and these paths within the subregions are interconnected
with bridges. In intricate domains with abundant voids and irregular
boundaries, the added subregion boundaries increase the path avoidance
requirements. This results in excessive bridging and necessitates longer
uneven-density spirals to achieve complete subregion coverage. Considering that
conformal slit mapping can transform multi-connected regions into regular disks
or annuluses without subregion division, this paper presents a novel spiral
complete coverage path planning method by conformal slit mapping. Firstly, a
slit mapping calculation technique is proposed for segmented cubic spline
boundaries with corners. Then, a spiral path spacing control method is
developed based on the maximum inscribed circle radius between adjacent
conformal slit mapping iso-parameters. Lastly, the spiral path is derived by
offsetting iso-parameters. The complexity and applicability of the proposed
method are comprehensively analyzed across various boundary scenarios.
Meanwhile, two cavities milling experiments are conducted to compare the new
method with conventional spiral complete coverage path methods. The comparation
indicate that the new path meets the requirement for complete coverage in
cavity machining while reducing path length and machining time by 12.70% and
12.34%, respectively.Comment: This article has not been formally published yet and may undergo
minor content change
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
<p>Abstract</p> <p>Background</p> <p>Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resistance of tumor cells during chemotherapy. In this study, the effects and mechanisms of GA and the NF-kappa B inhibitor celastrol on oral cancer cells were investigated.</p> <p>Methods</p> <p>Three human oral squamous cell carcinoma cell lines, Tca8113, TSCC and NT, were treated with GA alone, celastrol alone or GA plus celastrol. Cytotoxicity was assessed by MTT assay. The rate of apoptosis was examined with annexin V/PI staining as well as transmission electronic microscopy in Tca8113 cells. The level of constitutive NF-kappa B activity in oral squamous cell carcinoma cell lines was determined by immunofluorescence assays and nuclear extracts and electrophoretic mobility shift assays (EMSAs) <it>in vitro</it>. To further investigate the role of NF-kappa B activity in GA and celastrol treatment in oral squamous cell carcinoma, we used the dominant negative mutant SR-IκBα to inhibit NF-kappa B activity and to observe its influence on the effect of GA.</p> <p>Results</p> <p>The results showed that GA could inhibit the proliferation and induce the apoptosis of the oral squamous cell carcinoma cell lines and that the NF-kappa B pathway was simultaneously activated by GA treatment. The minimal cytotoxic dose of celastrol was able to effectively suppress the GA-induced NF-kappa B pathway activation. Following the combined treatment with GA and the minimal cytotoxic dose of celastrol or the dominant negative mutant SR-IκBα, proliferation was significantly inhibited, and the apoptotic rate of Tca8113 cells was significantly increased.</p> <p>Conclusion</p> <p>The combination of GA and celastrol has a synergistic antitumor effect. The effect can be primarily attributed to apoptosis induced by a decrease in NF-kappa B pathway activation. The NF-kappa B signaling pathway plays an important role in this process. Therefore, combining GA and celastrol may be a promising modality for treating oral squamous cell carcinoma.</p
Inclusive cross section and double helicity asymmetry for \pi^0 production in p+p collisions at sqrt(s)=200 GeV: Implications for the polarized gluon distribution in the proton
The PHENIX experiment presents results from the RHIC 2005 run with polarized
proton collisions at sqrt(s)=200 GeV, for inclusive \pi^0 production at
mid-rapidity. Unpolarized cross section results are given for transverse
momenta p_T=0.5 to 20 GeV/c, extending the range of published data to both
lower and higher p_T. The cross section is described well for p_T < 1 GeV/c by
an exponential in p_T, and, for p_T > 2 GeV/c, by perturbative QCD. Double
helicity asymmetries A_LL are presented based on a factor of five improvement
in uncertainties as compared to previously published results, due to both an
improved beam polarization of 50%, and to higher integrated luminosity. These
measurements are sensitive to the gluon polarization in the proton, and exclude
maximal values for the gluon polarization.Comment: 375 authors, 7 pages, 3 figures. Submitted to Phys. Rev. D, Rapid
Communications. Plain text data tables for the points plotted in figures for
this and previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
System Size and Energy Dependence of Jet-Induced Hadron Pair Correlation Shapes in Cu+Cu and Au+Au Collisions at sqrt(s_NN) = 200 and 62.4 GeV
We present azimuthal angle correlations of intermediate transverse momentum
(1-4 GeV/c) hadrons from {dijets} in Cu+Cu and Au+Au collisions at sqrt(s_NN) =
62.4 and 200 GeV. The away-side dijet induced azimuthal correlation is
broadened, non-Gaussian, and peaked away from \Delta\phi=\pi in central and
semi-central collisions in all the systems. The broadening and peak location
are found to depend upon the number of participants in the collision, but not
on the collision energy or beam nuclei. These results are consistent with sound
or shock wave models, but pose challenges to Cherenkov gluon radiation models.Comment: 464 authors from 60 institutions, 6 pages, 3 figures, 2 tables.
Submitted to Physical Review Letters. Plain text data tables for the points
plotted in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
Measurement of high-p_T Single Electrons from Heavy-Flavor Decays in p+p Collisions at sqrt(s) = 200 GeV
The momentum distribution of electrons from decays of heavy flavor (charm and
beauty) for midrapidity |y| < 0.35 in p+p collisions at sqrt(s) = 200 GeV has
been measured by the PHENIX experiment at the Relativistic Heavy Ion Collider
(RHIC) over the transverse momentum range 0.3 < p_T < 9 GeV/c. Two independent
methods have been used to determine the heavy flavor yields, and the results
are in good agreement with each other. A fixed-order-plus-next-to-leading-log
pQCD calculation agrees with the data within the theoretical and experimental
uncertainties, with the data/theory ratio of 1.72 +/- 0.02^stat +/- 0.19^sys
for 0.3 < p_T < 9 GeV/c. The total charm production cross section at this
energy has also been deduced to be sigma_(c c^bar) = 567 +/- 57^stat +/-
224^sys micro barns.Comment: 375 authors from 57 institutions, 6 pages, 3 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Suppression of back-to-back hadron pairs at forward rapidity in d+Au Collisions at sqrt(s_NN)=200 GeV
Back-to-back hadron pair yields in d+Au and p+p collisions at sqrt(s_NN)=200
GeV were measured with the PHENIX detector at the Relativistic Heavy Ion
Collider. Rapidity separated hadron pairs were detected with the trigger hadron
at pseudorapidity |eta|<0.35 and the associated hadron at forward rapidity
(deuteron direction, 3.0<eta<3.8). Pairs were also detected with both hadrons
measured at forward rapidity; in this case the yield of back-to-back hadron
pairs in d+Au collisions with small impact parameters is observed to be
suppressed by a factor of 10 relative to p+p collisions. The kinematics of
these pairs is expected to probe partons in the Au nucleus with low fraction x
of the nucleon momenta, where the gluon densities rise sharply. The observed
suppression as a function of nuclear thickness, p_T, and eta points to cold
nuclear matter effects arising at high parton densities.Comment: 381 authors, 6 pages, 4 figures. Published in Phys. Rev. Lett.
(http://link.aps.org/doi/10.1103/PhysRevLett.107.172301). v3 has minor
changes to match published version
(http://www.phenix.bnl.gov/phenix/WWW/info/pp1/128/PhysRevLett.107.172301)
Plain text data tables for points plotted in figures are publicly available
at http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg128_data.htm
Observation of direct-photon collective flow in sqrt(s_NN)=200 GeV Au+Au collisions
The second Fourier component v_2 of the azimuthal anisotropy with respect to
the reaction plane was measured for direct photons at midrapidity and
transverse momentum (p_T) of 1--13 GeV/c in Au+Au collisions at sqr(s_NN)=200
GeV. Previous measurements of this quantity for hadrons with p_T < 6 GeV/c
indicate that the medium behaves like a nearly perfect fluid, while for p_T > 6
GeV/c a reduced anisotropy is interpreted in terms of a path-length dependence
for parton energy loss. In this measurement with the PHENIX detector at the
Relativistic Heavy Ion Collider we find that for p_T > 4 GeV/c the anisotropy
for direct photons is consistent with zero, as expected if the dominant source
of direct photons is initial hard scattering. However, in the p_T < 4 GeV/c
region dominated by thermal photons, we find a substantial direct photon v_2
comparable to that of hadrons, whereas model calculations for thermal photons
in this kinematic region significantly underpredict the observed v_2.Comment: 384 authors, 6 pages, 3 figures, and 1 table. Submitted to Phys. Rev.
Lett. v2 has minor changes to match the submission version. Plain text data
tables for the points plotted in the figures are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg126_data.htm
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Measurement of Bottom versus Charm as a Function of Transverse Momentum with Electron-Hadron Correlations in p+p Collisions at sqrt(s)=200 GeV
The momentum distribution of electrons from semi-leptonic decays of charm and
bottom for mid-rapidity |y|<0.35 in p+p collisions at sqrt(s)=200 GeV is
measured by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC)
over the transverse momentum range 2 < p_T < 7 GeV/c. The ratio of the yield of
electrons from bottom to that from charm is presented. The ratio is determined
using partial D/D^bar --> e^{+/-} K^{-/+} X (K unidentified) reconstruction. It
is found that the yield of electrons from bottom becomes significant above 4
GeV/c in p_T. A fixed-order-plus-next-to-leading-log (FONLL) perturbative
quantum chromodynamics (pQCD) calculation agrees with the data within the
theoretical and experimental uncertainties. The extracted total bottom
production cross section at this energy is \sigma_{b\b^bar}= 3.2
^{+1.2}_{-1.1}(stat) ^{+1.4}_{-1.3}(syst) micro b.Comment: 432 authors, 6 pages text, 3 figures. Submitted to Phys. Rev. Lett.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
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