Analysis of the children's dynamic and static stereopsis of intermittent exotropia

AIM: To compare and analyze the stereopsis of intermittent exotropia children under the different backgrounds of dynamic stimuli and static stimuli.<p>METHODS: We collected 56 children(male 26, female 30 with intermittent exotropia at the age from 5y to 12y and examined their stereopsis under the different backgrounds of dynamic stimuli and static stimuli using a multidimensional sense perception training software. The differences between the dynamic stereopsis and static stereopsis were compared.<p>RESULTS: Totally 17 cases(30%)had both dynamicstereopsis and static stereopsis, 39 cases(70%)had either dynamic or static stereopsis deficit, only 10 cases(26%)had dynamic stereopsis, 25 cases(64%)static stereopsis left and 4 cases(10%)were without any form of stereopsis. The positive rate of dynamic stereopsis was better than the positive rate of static stereopsis, with statistical significance(<i>P</i><0.05).<p>CONCLUSION: Dynamicstereopsis is better than the static stereopsis to intermittent exotropia children

Effect of Buyanghuangwu recipe on exhausted mice skeletal muscle mitochondrial ultrastructure and function

目的  通过建立小鼠游泳运动疲劳模型，探讨补阳还五汤（BYHWT）对运动性疲劳小鼠骨骼肌线粒体超微结构及蛋白AMPK表达的影响。方法  实验选用健康雄性清洁级SD小鼠48只，随机均分为对照组和补阳还五汤低、中、高剂量组，每组12只。常规饲料喂养外，BYHWT低、中、高剂量组分别给予12.5ｇ/kg、25.0ｇ/kg、50.0ｇ/kg的BYHWT灌胃，对照组给予等量生理盐水，连续给药7天，采用负重游泳实验建立小鼠力竭模型。用透射电镜观察骨骼肌细胞线粒体超微结构，Real-time PCR法测定骨骼肌AMPK蛋白表达。结果  运动性疲劳小鼠骨骼肌线粒体数量明显减少，线粒体空泡样变，嵴断裂显著，核染色质浓缩边集、核缩小、核膜增厚，而补阳还五汤药物干预后，骨骼肌线粒体形态趋于正常；模型组大鼠骨骼肌组织AMPK蛋白表达水平较正常对照组、补阳还五汤组明显降低，差异有显著性（P＜0.05），而正常对照组和补阳还五汤组间差异无显著性（P＞0.05）。结论  补阳还五汤具有一定的抗运动性疲劳作用，其机制可能与其减少线粒体损伤，增强线粒体功能，增加骨骼肌AMPK蛋白表达有关。Objective: Discusses the influence that Buyanghuangwu recipe for exercise-induced fatigue mice skeletal muscle mitochondrial ultrastructure and the influence of AMPK protein expression, by establishing mice swimming exercise fatigue model. Methods: 48 SD mice of healthy male at clean level were chose to do experiments, randomly divided into control group and BYHWR low, medium and high group, each group of 12. Regular feed, BYHWR low, medium and high group were given 12.5g/kg, 25.0g/kg, 50.0g/kg for BYHWR to fill the stomach, the control group given amount of normal saline, administered continuously for 7d, weight loading swimming experiment is adopted to establish the mice model of exhaustion. Skeletal muscle cells are observed by transmission electron microscope mitochondria ultrastructure, Real-time PCR method skeletal muscle AMPK protein expression. Results: The number of mitochondria in skeletal muscle of exercise-induced fatigue mice decreased significantly, mitochondrial vacuole degeneration, rupture of mitochondria were obvious, nucleus chromatin concentrated edge set, nucleus contracted and nuclear membrane thickened. After intervention of BYHWR, skeletal muscle The expression of AMPK protein in the skeletal muscle of the model group was significantly lower than that of the normal control group and the group of BYHWR group (P&lt;0.05). The expression of AMPK protein in the normal control group and BYHWR group was no significant difference between the two groups (P&gt;0.05). Conclusion: BYHWR group has certain resistance exercise fatigue, and its mechanisms potentially increase AMPK protein expression in skeletal muscle, reduce mitochondrial damage, and strengthen the function of mitochondria

Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma

<p>Abstract</p> <p>Background</p> <p>Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their potential therapeutic values.</p> <p>Methods</p> <p>Eighty-nine IHCC patients were retrospectively assessed for their expression of CTAs and HLA Class I by immunohistochemistry using the following antibodies: MA454 recognizing MAGE-A1, 57B recognizing multiple MAGE-A (MAGE-A3/A4), E978 recognizing NY-ESO-1, and EMR8-5 recognizing HLA class I. The clinicopathological and prognostic significance of individual CTA markers and their combination were further evaluated.</p> <p>Results</p> <p>The expression rates of MAGE-A1, MAGE-A3/4 and NY-ESO-1 were 29.2%, 27.0% and 22.5%, respectively. The concomitant expression of CTAs and HLA class I antigen was observed in 33.7% of the IHCC tumors. We found that positive MAGE-3/4 expression correlated with larger tumor size (≥ 5 cm), tumor recurrence and poor prognosis. Moreover, we identified 52 cases (58.4%) of IHCC patients with at least one CTA marker expression, and this subgroup displayed a higher frequency of larger tumor size and a shorter survival than the other cases. Furthermore, expression of at least one CTA marker was also an independent prognostic factor in patients with IHCC.</p> <p>Conclusion</p> <p>Our data suggest that specific immunotherapy targeted CTAs might be a novel treatment option for IHCC patients.</p

Characterization of CoTiO3 Nanocrystallites Prepared by Homogeneous Precipitation Method

Nanocrystalline cobalt titanate (CoTiO3) has been synthesized from a well-mixed precursor. The precursor was prepared by a homogeneous precipitation method, in which urea was used as the precipitator. The as-synthesized sample is a mixture of CoTiO3 and rutile nanocrystallites with mean sizes of around 50 nm. It strongly absorbs visible light in the wavelength range of 500-690 nm besides ultraviolet light (wavelength < 370 nm). We found the synthetic CoTiO3 is a semiconducting material with a direct band gap of 2.53 eV. The green CoTiO3 has two absorbance peaks at the wavelengths of 537 and 606 nm, which correspond to the photon energies of 2.31 and 2.05 eV, respectively. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3195

Aqua­(3-fluoro­benzoato-κO)(3-fluoro­benzoato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)cobalt(II)

In the title compound, [Co(C7H4FO2)2(C12H8N2)(H2O)], the CoII ion is coordinated by two O atoms from one 3-fluoro­benzoate (fb) ligand and one O atom from another fb ligand, two N atoms from the 1,10-phenanthroline ligand and a water mol­ecule in a distorted octa­hedral geometry. An intra­molecular O—H⋯O hydrogen bond occurs. Inter­molecular O—H⋯O hydrogen bonds link pairs of mol­ecules into centrosymmetric dimers. Weak inter­molecular C—H⋯O and C—H⋯F hydrogen bonds and π–π inter­actions between the aromatic rings [shortest centroid–centroid distance = 3.4962 (2) Å] further stabilize the crystal packing

Graphene Functionalization of Polyrotaxane-Encapsulated PEG-Based PCMs: Fabrication and Applications.

Phase change materials (PCMs) have received much attention regarding the thermal regulation of electronic devices. However, the main limitations of using organic PCMs are the low thermal conductivity and leakage during the phase change process. This work aims to improve these limitations to increase the thermal conductivity of the leakage-proof PCM formed by a polyrotaxane that serves as a support material to encapsulate PEG. For this purpose, different contents of graphene nanoplatelets (GNP) are blended. To facilitate its postindustrial production and to meet ecological standards, the synthesis of this PCM is simple and only using water as a solvent. The PCMs can be thermally processed conveniently by a hot press. Furthermore, the PCMs achieve high enthalpy values (132.9–142.9 J g−1) due to the action of GNPs as thermally conductive fillers. The PCMs exhibited an increase of 60–257% in thermal conductivity values with higher GNP content, and show great shape stability and no leakage during phase change. These improvements solve the main problems of organic PCMs, thus making PLR-PEG-GNP-based materials a good candidate for use as thermal energy storage materials in industrial applications as thermoregulators of solid-state disks or realizing the “shaving peaks and filling valleys” effect for thermoelectric generators.pre-print1654 K

Structural design of a silicon six-wafer micro-combustor under the effect of heat transfer boundary condition at the outer walls

The aim of this investigation was to establish a methodology for designing highly stressed micro fabricated structures by studying the structural design issues associated with a silicon six–wafer micro combustor under the effect of heat transfer boundary condition at the outer walls. Some experimental and numerical simulation results have indicated that the flame can not be sustained in the micro combustor if the poor heat transfer coefficients at the outer wall are present. This could cause the combustor wall temperature higher than the auto ignition temperature of reactants and results in the upstream burning. Since silicon has relatively poor high temperature strength and creep resistance when the temperature is above the brittle to ductile transition temperature (BDTT), e.g. 900K, the combustion in the recirculation jacket could possibly damage the micro combustor due to the high wall temperature

Sodium alginate and Chitosan aided design of form-stable Polyrotaxane based phase change materials with ultra-high latent heat.

We prepared a series of highly porous Polyrotaxane/sodium alginate, and Polyrotaxane/Chitosan foam alloys according to a sustainable pathway by using water as the only solvent. The foam alloys were further used as supporter materials for poly (ethylene glycol) (PEG) encapsulation, to fabricate shape-stable bio-based phase change materials (PCMs). The pore morphology and the internal interface between PEG and foam alloys were characterized by scanning electron microscope (SEM). Due to the good compatibility between foam alloys and PEG, the PCM performed perfect anti-leakage properties. The introduction of sodium alginate or Chitosan ensures the shape stability of the PCMs during the phase transition. The PCMs performed good cycle stability and showed ultra-high latent heat (171.6 J g−1–189.5 J g−1). Finally, we compared the typical indicators of this work with those reported in the literature, and the comparison highlighted that the present PCMs have the significant advantages: high melting enthalpy, convenient preparation and outstanding sustainability. Notably, the work provided a sustainable idea for the design of anti-leakage and shape-stable PEG-based PCMs.pre-print1327 K

Bio-based poly (glycerol-itaconic acid)/PEG/APP as form stable and flame-retardant phase change materials

With the improvement of people's living level, smart home and comfortable life put forward novel and highly scientific requirements for building materials and home environment. Environmental protection, renewability, processing convenience and use safety (non-toxic/fire safety) are all core indicators that need to be considered in an all-round way in the process of material design. In this work, we used a simple and efficient green process by blending ammonium polyphosphate (APP) and poly (glycerol-itaconic acid) loaded polyethylene glycol (PEG) to prepare fire safe phase change materials (PCMs). The flame retardancy, phase change performance and thermal response behavior (including form stability, thermal conductivity, cycle stability, and latent heat etc.) were systematically characterized. The results showed that limiting oxygen index (LOI) increased significantly with the increase of APP content. Typically, when the filling amount of APP reached 15 wt%, the LOI value increased from 21.6% to 28.7%, vertical testing reached UL-94 V0 rating and the pHRR decreased by 36.15%. The as-prepared PCMs show excellent form stability, and the enthalpy of phase change keeps higher than 70 J g−1, which is at the high level as that of same kinds of PCMs. Notably, due to its high preparation efficiency for PCM fabrication and the profiles of all bio-based supporting matrix, solvent-free pathway, mild curing temperature, and fire safety, it is expected to be effectively applied in building for the thermal regulation.pre-print1269 K

PLA aerogel as a universal support for the typical organic phase change energy storage materials.

We first prepared Polylactic acid (PLA) aerogels with high porosity based on a facile and efficient thermal induced phase separation technique. In view of the excellent internal nano structure of PLA aerogel, high porosity and suitable interfacial affinity, it was selected as a support material to encapsulate four common organic phase change materials (PCMs), thereby preparing anti-leakage, shape-stable and sustainable PCMs with ultra-high latent heat (178.9–224.9 J g−1). PLA aerogel encapsulated PCMs perform high enthalpy efficiency (>92 %), which may benefit from the highly internal compatible nanostructure of PLA. Thermally conductive fillers (Boron nitride and Graphene nanoplatelet) were introduced to improve thermal conductivity. An important factor of PLA aerogel as a universal encapsulation matrix is analyzed based on the solubility parameters and Flory-Huggins parameters. The application cases of smart container and thermal regulation in confined spaces further prove the practical application value in the thermal regulation and energy saving area.pre-print2189 K