2,808 research outputs found
Prevalence of insomnia symptoms and their associated factors in patients treated in outpatient clinics of four general hospitals in Guangzhou, China
Background: Data on the prevalence of insomnia symptoms in medical outpatient clinics in China are lacking. This study examined the prevalence of insomnia symptoms and their socio-demographic correlates in patients treated at medical outpatient clinics affiliated with four general hospitals in Guangzhou, a large metropolis in southern China.
Method: A total of 4399 patients were consecutively invited to participate in the study. Data on insomnia and its socio-demographic correlates were collected with standardized questionnaires.
Results: The prevalence of any type of insomnia symptoms was 22.1% (95% confidence interval (CI): 20.9–23.3%); the prevalence of difficulty initiating sleep was 14.3%, difficulty maintaining sleep was 16.2%, and early morning awakening was 12.4%. Only 17.5% of the patients suffering from insomnia received sleeping pills. Multiple logistic regression analysis revealed that male gender, education level, rural residence, and being unemployed or retired were negatively associated with insomnia symptoms, while lacking health insurance, older age and more severe depressive symptoms were positively associated with insomnia symptoms.
Conclusions: Insomnia symptoms are common in patients attending medical outpatient clinics in Guangzhou. Increasing awareness of sleep hygiene measures, regular screening and psychosocial and pharmacological interventions for insomnia are needed in China.
Trial registration: ChiCTR-INR-16008066. Registered 8 March 2016
Mutual-Chern-Simons effective theory of doped antiferromagnets
A mutual-Chern-Simons Lagrangian is derived as a minimal field theory
description of the phase-string model for doped antiferromagnets. Such an
effective Lagrangian is shown to retain the full symmetries of parity,
time-reversal, and global SU(2) spin rotation, in contrast to conventional
Chern-Simons theories where first two symmetries are usually broken. Two
ordered phases, i.e., antiferromagnetic and superconducting states, are found
at low temperatures as characterized by dual Meissner effects and dual flux
quantization conditions due to the mutual-Chern-Simons gauge structure. A dual
confinement in charge/spin degrees of freedom occurs such that no true
spin-charge separation is present in these ordered phases, but the spin-charge
separation/deconfinement serves as a driving force in the unconventional phase
transitions of these ordered states to disordered states.Comment: 16 pages, 2 figures; published versio
The prevalence of autism spectrum disorders in China: A comprehensive meta-analysis
There are conflicting prevalence estimates of autism spectrum disorders (ASDs) in mainland China (China thereafter). This study is a comprehensive meta-analysis of the pooled prevalence of ASDs in the general population in China. Study investigators independently conducted a systematic literature search of the following databases: PubMed, EMBASE, PsycINFO, China National Knowledge Infrastructure, Chinese biomedical literature service system, and Wan Fang. Studies reporting prevalence of ASDs and autism in Chinese population were identified and analysed using the Comprehensive Meta-Analysis program with the random effects model. Forty-four studies were included in the meta-analysis comprising 2,337,321 subjects of whom 46.66 % were females. The mean age of subjects ranged from 1.6 to 8 years. Based on diagnostic criteria the pooled prevalence of ASDs was 39.23 per 10,000 (95% CI: 28.44-50.03 per 10,000, I2=89.2%); specifically, the prevalence of autism was 10.18 per 10,000 (95% CI: 8.46-11.89 per 10,000, I2=92.5%). Subgroup analyses revealed significant difference in the prevalence of ASDs between genders (72.77 per 10,000 in males vs. 16.45 per 10,000 in females). In conclusion, the prevalence of ASDs and autism in China was found generally lower than those reported in other countries. Further studies are needed to clarify the variation in prevalence
Topological Superconductivity in Multifold Fermion Metals
Recently, multifold fermions characterized by band crossings with multifold
degeneracy and Fermi surfaces with nontrivial Chern numbers have been
discovered experimentally in AlPt[arXiv:1812.03310] and
XSi(X=Rh,Co)[arXiv:1812.04466][arXiv:1901.03358][arXiv:1809.01312]. In this
work, we largely expand the family of multifold fermion materials by pointing
out that several well-studied noncentrosymmetric superconductors are indeed
multifold fermion metals. Importantly, their normal state topological
properties, which have been ignored in previous studies, play an important role
in the superconducting properties. Taking LiPdB and LiPtB as
examples, we found a large number of unconventional degenerate points, such as
double spin-1, spin-3/2, Weyl and double Weyl topological band crossing points
near the Fermi energy, which result in finite Chern numbers on Fermi surfaces.
Long Fermi arc states in LiPdB, originating from the nontrivial band
topology were found. Importantly, it has been shown experimentally that
LiPdB and LiPtB are fully gapped and gapless superconductors,
respectively. By analyzing the possible pairing symmetries, we suggest that
LiPdB can be a DIII class topological superconductor with Majorana
surface states, even though the spin-orbit coupling in LiPdB is
negligible. Interestingly, LiPtB, being gapless, is likely to be a
nodal topological superconductor with dispersionless surface Majorana modes. We
further identified that several noncentrosymmetric superconductors, such as
MoAlC, PdBiSe, YC and LaC, are multifold fermion
superconductors whose normal state topological properties have been ignored in
previous experimental and theoretical studies
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a plausible mechanism of STAT3 hyperactivation. We analyzed whole exome sequencing (n = 374) and reverse-phase protein array data (n = 212) from head and neck squamous cell carcinomas (HNSCCs). PTPR mutations are most common and are associated with significantly increased phospho-STAT3 expression in HNSCC tumors. Expression of receptor-like protein tyrosine phosphatase T (PTPRT) mutant proteins induces STAT3 phosphorylation and cell survival, consistent with a “driver” phenotype. Computational modeling reveals functional consequences of PTPRT mutations on phospho-tyrosine–substrate interactions. A high mutation rate (30%) of PTPRs was found in HNSCC and 14 other solid tumors, suggesting that PTPR alterations, in particular PTPRT mutations, may define a subset of patients where STAT3 pathway inhibitors hold particular promise as effective therapeutic agents.Fil: Lui, Vivian Wai Yan. University of Pittsburgh; Estados UnidosFil: Peyser, Noah D.. University of Pittsburgh; Estados UnidosFil: Ng, Patrick Kwok-Shing. University Of Texas Md Anderson Cancer Center;Fil: Hritz, Jozef. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Masaryk University; República ChecaFil: Zeng, Yan. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Lu, Yiling. University Of Texas Md Anderson Cancer Center;Fil: Li, Hua. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Wang, Lin. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Gilbert, Breean R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: General, Ignacio. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Bahar, Ivet. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Ju, Zhenlin. University Of Texas Md Anderson Cancer Center;Fil: Wang, Zhenghe. Case Western Reserve University; Estados UnidosFil: Pendleton, Kelsey P.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Xiao, Xiao. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Du, Yu. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Vries, John K.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Hammerman, Peter S.. Harvard Medical School; Estados UnidosFil: Garraway, Levi A.. Harvard Medical School; Estados UnidosFil: Mills, Gordon B.. University Of Texas Md Anderson Cancer Center;Fil: Johnson, Daniel E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Grandis, Jennifer R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unido
Sensing User's Activity, Channel, and Location with Near-Field Extra-Large-Scale MIMO
This paper proposes a grant-free massive access scheme based on the
millimeter wave (mmWave) extra-large-scale multiple-input multiple-output
(XL-MIMO) to support massive Internet-of-Things (IoT) devices with low latency,
high data rate, and high localization accuracy in the upcoming sixth-generation
(6G) networks. The XL-MIMO consists of multiple antenna subarrays that are
widely spaced over the service area to ensure line-of-sight (LoS)
transmissions. First, we establish the XL-MIMO-based massive access model
considering the near-field spatial non-stationary (SNS) property. Then, by
exploiting the block sparsity of subarrays and the SNS property, we propose a
structured block orthogonal matching pursuit algorithm for efficient active
user detection (AUD) and channel estimation (CE). Furthermore, different
sensing matrices are applied in different pilot subcarriers for exploiting the
diversity gains. Additionally, a multi-subarray collaborative localization
algorithm is designed for localization. In particular, the angle of arrival
(AoA) and time difference of arrival (TDoA) of the LoS links between active
users and related subarrays are extracted from the estimated XL-MIMO channels,
and then the coordinates of active users are acquired by jointly utilizing the
AoAs and TDoAs. Simulation results show that the proposed algorithms outperform
existing algorithms in terms of AUD and CE performance and can achieve
centimeter-level localization accuracy.Comment: Submitted to IEEE Transactions on Communications, Major revision.
Codes will be open to all on https://gaozhen16.github.io/ soo
Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life
Few studies have compared the prevalence of smoking between patients with bipolar disorder, major depressive disorder (MDD) and schizophrenia. This study examined the prevalence of smoking and its relationships with demographic and clinical characteristics, and quality of life (QOL) in patients with these psychiatric disorders. A total of 1,102 inpatients were consecutively screened. Psychopathology and QOL were measured with standardized instruments. The prevalence of current smoking in the whole sample was 16.7%; 17.5% in bipolar disorder, 10.6% in MDD and 18.5% in schizophrenia. The rates of smoking in bipolar disorder (p = 0.004, OR = 2.5, 95%CI: 1.3–4.7) and schizophrenia (p = 0.03, OR = 2.0, 95%CI: 1.06–3.8) were significantly higher than in MDD, while no difference was found between bipolar disorder and schizophrenia. Smokers had a higher mental QOL than non-smokers (p = 0.007) in MDD, but no difference was found in the other two groups. Male gender, living alone, higher personal income, older age of onset, health insurance coverage, and first episode was significantly associated with smoking in one or more diagnostic groups. Smoking appears more common in bipolar disorder and schizophrenia than in MDD in China. The figures in all disorders were lower than that reported in most of other countries
Numerical modelling of buried pipelines under DC stray current corrosion
Corrosion of buried pipelines caused by stray currents is becoming a serious industrial and environmental problem. It is therefore necessary to study corrosion mechanisms of buried pipelines under DC stray currents in order to propose effective anti-corrosion measures. Since measurement of the potential is one of important ways to identify stray current intensity, the COMSOL Multiphysics software was used to simulate stray current corrosion dynamics of buried pipelines. It was also used to calculate the distribution and intensity changes of electrolyte potential in the cathodic protected system by solving Laplace’s three-dimensional equation. The obtained results showed that increased applied voltage leads to more positive shift of a pipeline potential, resulting in acceleration of stray current corrosion. On the contrary, increased soil resistivity can retard the corrosion process. The protected pipeline with a sacrificial anode suffers less corrosion interference than unprotected pipeline. Two crossed arrangement of pipelines makes no difference in corrosion of protected pipeline, but affects greatly on unprotected pipeline
Children\u27s exposure to food advertising on free-to-air television: an Asia-Pacific perspective
There is an established link between food promotions and children\u27s food purchase and consumption. Children in developing countries may be more vulnerable to food promotions given the relative novelty of advertising in these markets. This study aimed to determine the scope of television food advertising to children across the Asia-Pacific to inform policies to restrict this marketing. Six sites were sampled, including from China, Indonesia, Malaysia and South Korea. At each site, 192 h of television were recorded (4 days, 16 h/day, three channels) from May to October 2012. Advertised foods were categorized as core/healthy, non-core/unhealthy or miscellaneous, and by product type. Twenty-seven percent of advertisements were for food/beverages, and the most frequently advertised product was sugar-sweetened drinks. Rates of non-core food advertising were highest during viewing times most popular with children, when between 3 (South Korea) and 15 (Indonesia) non-core food advertisements were broadcast each hour. Children in the Asia-Pacific are exposed to high volumes of unhealthy food/beverage television advertising. Different policy arrangements for food advertising are likely to contribute to regional variations in advertising patterns. Cities with the lowest advertising rates can be identified as exemplars of good policy practice
- …