Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration

Electrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds, which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75 ± 9.78 μm2 ) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/ CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad implications for regenerative medicine and tissue engineering applications.info:eu-repo/semantics/publishedVersio

Construction of Safety Management and Control Ability Evaluation System for Leading Group of Coal Enterprises

Based on the increasingly severe and complex situation of coal mine safety production, there are still many problems in the basic management of safety production. In order to further improve the level of coal mine safety production management and build an efficient coal mine safety management system, Lu’an Group first proposed the management idea of evaluating the safety management and control ability of coal mine leading group. Lu’an Group, in accordance with the relevant regulations of the superior and in combination with its own characteristic of basic safety management mode, reasonably determines the evaluation items, formulates evaluation and scoring rules, regularly evaluates and assesses the safety management and control ability of the leading group of each mine and analyzes the causes, promotes them to have a deep understanding of their own shortcomings, takes targeted measures to make up for the shortcomings of safety management, continuously improves and perfects working methods, and effectively gives full play to the core leadership role of the team, leads the staff of the whole mine to earnestly perform their post responsibilities, unites and cooperates with each other, concentrates and gathers strength, and pushes forward the work of coal mine safety production

Investigation on Antioxidant Activity and Different Metabolites of Mulberry (<i>Morus</i> spp.) Leaves Depending on the Harvest Months by UPLC–Q-TOF-MS with Multivariate Tools

The changes in active components in mulberry leaves harvested in different months and their antioxidant activities were investigated. Ultra-high-performance liquid chromatography–tandem quadrupole time-of-flight mass spectrometry (UPLC–Q-TOF-MS) with multivariate statistical tools was used to investigate the chemical constituents in the extracts of mulberry leaves. The results indicated that mulberry leaves were rich in phenolic acids, flavonoids, organic acids, and fatty acid derivatives. In addition, 25 different compounds were identified in the different batches of mulberry leaves. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was measured to evaluate the in vitro antioxidant activities of mulberry leaves. Among the four batches, batch A, harvested in December, exhibited the strongest DPPH radical-scavenging activity, while batch B, harvested in March, showed the weakest activity. This was related to the total phenolic content in the mulberry leaves of each batch. The optimal harvest time of mulberry leaves greatly influences the bioactivity and bioavailability of the plant