A digital definition method for manufacturing model of aircraft integral panel

The manufacturing model of aircraft integral panel is presented based on the analysis of its structure and manufacturing process. The manufacturing model for each key process consists of model for processing and model for workpiece to bridge digital design and fabricating. Model for workpiece is used to express the target part information at the end of some operation. Model for processing is used to describe the intermediate state information, and it aims to attain but is different the workpiece because of process factors. The definition flow of the manufacturing model is given. The modeling approach of integral panel part blank from shot peen forming part model orienting to NC cutting is proposed and exemplified. It is analyzed that the approaches above can define the models accurately and totally to meet the needs of process planning , NC fabricating and inspecting

Effects of Soybean Aphid, Aphis glycines on Soybean Growth and Yield

Population dynamics of the soybean aphid, Aphis glycines and its effects on soybean growth and yield were surveyed in 1989-1990. Experiments were conducted in the naturally infested plots and in the treated plots using 10% enhanced Dimethoate. In 1989, soybean aphids in the untreated plots developed earlier and increased rapidly. Aphid density per 100 plants on June 15th was over 10,000, and the rapid development period was over 40 d. But aphids in 1990 developed slightly later with a shorter development period. Soybeans in the untreated plots significantly displayed the symptoms of distorted leaves, shorter stems and stunted plants. Plants in the treated plots were higher (20.2 cm in 1989) than those in the untreated plots. Soybean aphids significantly affected soybean yields. Yields in the untreated plots reduced 27.8% compared to that in the treated plots in 1989.Originating text in Chinese.Citation: Wang, Suyun, Bao, Xiangzhi, Sun, Yajie, Chen, Ruilu, Zhai, Baoping, Bao, Xiangzhi. (1996). Effects of Soybean Aphid, Aphis glycines on Soybean Growth and Yield. Soybean Science, 15(3), 243-247

Damage and Control of Soybean Aphid

The soybean aphid, Aphis glycines, is one of the major insect pests of seedling soybean. This aphid has become a serious problem in soybean production due to heavy infestation in recent years and lack of favorable varieties resistant to soybean aphids. To understand the damage by soybean aphids and evaluation of control effect, in 1989-1990, we investigated the population dynamics of soybean aphid in the fields and its effect on soybean growth, development and yield.Originating text in Chinese.Citation: Wang, Suyun, Sun, Yajie, Chen, Ruilu, Zhai, Baoping, Bao, Xiangzhi. (1994). Damage and Control of Soybean Aphid. Technology and Promotion of Plant Protection, 2, 5-6

SAMIHS: Adaptation of Segment Anything Model for Intracranial Hemorrhage Segmentation

Segment Anything Model (SAM), a vision foundation model trained on large-scale annotations, has recently continued raising awareness within medical image segmentation. Despite the impressive capabilities of SAM on natural scenes, it struggles with performance decline when confronted with medical images, especially those involving blurry boundaries and highly irregular regions of low contrast. In this paper, a SAM-based parameter-efficient fine-tuning method, called SAMIHS, is proposed for intracranial hemorrhage segmentation, which is a crucial and challenging step in stroke diagnosis and surgical planning. Distinguished from previous SAM and SAM-based methods, SAMIHS incorporates parameter-refactoring adapters into SAM's image encoder and considers the efficient and flexible utilization of adapters' parameters. Additionally, we employ a combo loss that combines binary cross-entropy loss and boundary-sensitive loss to enhance SAMIHS's ability to recognize the boundary regions. Our experimental results on two public datasets demonstrate the effectiveness of our proposed method. Code is available at https://github.com/mileswyn/SAMIHS .Comment: 5 pages, 3 figures, 2 table

Intrinsic Cerebro-Cerebellar Functional Connectivity Reveals the Function of Cerebellum VI in Reading-Related Skills

Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC: 31971036, 31971039, and 31571158).Peer reviewedPublisher PD

Plasmonic Optical Tweezers for Particle Manipulation: Principles, Methods, and Applications

Inspired by the idea of combining conventional optical tweezers with plasmonic nanostructures, a technique named plasmonic optical tweezers (POT) has been widely explored from fundamental principles to applications. With the ability to break the diffraction barrier and enhance the localized electromagnetic field, POT techniques are especially effective for high spatial-resolution manipulation of nanoscale or even subnanoscale objects, from small bioparticles to atoms. In addition, POT can be easily integrated with other techniques such as lab-on-chip devices, which results in a very promising alternative technique for high-throughput single-bioparticle sensing or imaging. Despite its label-free, high-precision, and high-spatial-resolution nature, it also suffers from some limitations. One of the main obstacles is that the plasmonic nanostructures are located over the surfaces of a substrate, which makes the manipulation of bioparticles turn from a three-dimensional problem to a nearly two-dimensional problem. Meanwhile, the operation zone is limited to a predefined area. Therefore, the target objects must be delivered to the operation zone near the plasmonic structures. This review summarizes the state-of-the-art target delivery methods for the POT-based particle manipulating technique, along with its applications in single-bioparticle analysis/imaging, high-throughput bioparticle purifying, and single-atom manipulation. Future developmental perspectives of POT techniques are also discussed

雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应

文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。研究人员发现,雷公藤红素的结合

Ectopic Expression of Vaccinia Virus E3 and K3 Cannot Rescue Ectromelia Virus Replication in Rabbit RK13 Cells

Citation: Hand, E. S., Haller, S. L., Peng, C., Rothenburg, S., & Hersperger, A. R. (2015). Ectopic Expression of Vaccinia Virus E3 and K3 Cannot Rescue Ectromelia Virus Replication in Rabbit RK13 Cells. Plos One, 10(3), 15. doi:10.1371/journal.pone.0119189As a group, poxviruses have been shown to infect a wide variety of animal species. However, there is individual variability in the range of species able to be productively infected. In this study, we observed that ectromelia virus (ECTV) does not replicate efficiently in cultured rabbit RK13 cells. Conversely, vaccinia virus (VACV) replicates well in these cells. Upon infection of RK13 cells, the replication cycle of ECTV is abortive in nature, resulting in a greatly reduced ability to spread among cells in culture. We observed ample levels of early gene expression but reduced detection of virus factories and severely blunted production of enveloped virus at the cell surface. This work focused on two important host range genes, named E3L and K3L, in VACV. Both VACV and ECTV express a functional protein product from the E3L gene, but only VACV contains an intact K3L gene. To better understand the discrepancy in replication capacity of these viruses, we examined the ability of ECTV to replicate in wild-type RK13 cells compared to cells that constitutively express E3 and K3 from VACV. The role these proteins play in the ability of VACV to replicate in RK13 cells was also analyzed to determine their individual contribution to viral replication and PKR activation. Since E3L and K3L are two relevant host range genes, we hypothesized that expression of one or both of them may have a positive impact on the ability of ECTV to replicate in RK13 cells. Using various methods to assess virus growth, we did not detect any significant differences with respect to the replication of ECTV between wild-type RK13 compared to versions of this cell line that stably expressed VACV E3 alone or in combination with K3. Therefore, there remain unanswered questions related to the factors that limit the host range of ECTV