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雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应
Authors
Chenting Xu
Duo Zhang
+22 more
Fang Zhang
Fuquan Jiang
Gulimiran Alitongbieke
Hu Zhou
Hui Fang
Huibin Chen
Jie Liu
Jorge Moscat
Lei Xie
Lijun Cai
Maria T.Diaz-Meco
Mengjie Hu
Qiang Luo
Shanjun Yang
Shuyi Chong
Xiangzhi Lin
Xiaohong Ye
Xiaohui Chen
Ying Su
Yuqi Zhou
Zhaokai Wang
张晓坤
Publication date
25 April 2018
Publisher
Abstract
文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。研究人员发现,雷公藤红素的结合
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Last time updated on 10/06/2020