74 research outputs found
Robust Optical Data Encryption by Projection-Photoaligned Polymer-Stabilized-Liquid-Crystals
The emerging Internet of Things (IoTs) invokes increasing security demands
that require robust encryption or anti-counterfeiting technologies. Albeit
being acknowledged as efficacious solutions in processing elaborate graphical
information via multiple degrees of freedom, optical data encryption and
anti-counterfeiting techniques are typically inept in delivering satisfactory
performance without compromising the desired ease-of-processibility or
compatibility, thus leading to the exploration of novel materials and devices
that are competent. Here, a robust optical data encryption technique is
demonstrated utilizing polymer-stabilized-liquid-crystals (PSLCs) combined with
projection photoalignment and photopatterning methods. The PSLCs possess
implicit optical patterns encoded via photoalignment, as well as explicit
geometries produced via photopatterning. Furthermore, the PSLCs demonstrate
improved robustness against harsh chemical environments and thermal stability,
and can be directly deployed onto various rigid and flexible substrates. Based
on this, it is demonstrated that single PSLC is apt to carry intricate
information, or serve as exclusive watermark with both implicit features and
explicit geometries. Moreover, a novel, generalized design strategy is
developed, for the first time, to encode intricate and exclusive information
with enhanced security by spatially programming the photoalignment patterns of
a pair of cascade PSLCs, which further illustrates the promising capabilies of
PSLCs in optical data encryption and anti-counterfeiting
Thorium-doping induced superconductivity up to 56 K in Gd1-xThxFeAsO
Following the discovery of superconductivity in an iron-based arsenide
LaO1-xFxFeAs with a superconducting transition temperature (Tc) of 26 K[1], Tc
was pushed up surprisingly to above 40 K by either applying pressure[2] or
replacing La with Sm[3], Ce[4], Nd[5] and Pr[6]. The maximum Tc has climbed to
55 K, observed in SmO1-xFxFeAs[7, 8] and SmFeAsO1-x[9]. The value of Tc was
found to increase with decreasing lattice parameters in LnFeAsO1-xFx (Ln stands
for the lanthanide elements) at an apparently optimal doping level. However,
the F- doping in GdFeAsO is particularly difficult[10,11] due to the lattice
mismatch between the Gd2O2 layers and Fe2As2 layers. Here we report observation
of superconductivity with Tc as high as 56 K by the Th4+ substitution for Gd3+
in GdFeAsO. The incorporation of relatively large Th4+ ions relaxes the lattice
mismatch, hence induces the high temperature superconductivity.Comment: 4 pages, 3 figure
2D Materials Graphene related materials for thermal management Graphene related materials for thermal management
International audienceAlmost 15 years have gone ever since the discovery of graphene as a single atom layer. Numerous papers have been published to demonstrate its high electron mobility, excellent thermal and mechanical as well as optical properties. We have recently seen more and more applications towards using graphene in commercial products. This paper is an attempt to review and summarize the current status of the research of the thermal properties of graphene and other 2D based materials including the manufacturing and characterization techniques and their applications, especially in electronics and power modules. It is obvious from the review that graphene has penetrated the market and gets more and more applications in commercial electronics thermal management context. In the paper, we also made a critical analysis of how mature the manufacturing processes are; what are the accuracies and challenges with the various characterization techniques and what are the remaining questions and issues left before we see further more applications in this exciting and fascinating field. TOPICAL REVIE
NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop
CD166/ALCAM plays an important role in tumor aggression and progression as well as protecting cancer cells against apoptosis and autophagy. However, the mechanism by which pro-cell death signals control CD166 expression remains unclear. Here we show that following serum deprivation (SD), upregulation of CD166 protein is shorter than that of CD166 mRNA. Molecular analysis revealed both CD166 and miR-9-1 as two novel NF-κB target genes in hepatoma cells. In vivo activation and translocation of the NF-κB P50/P65 hetero-dimer into the nucleus following the phosphorylation and accompanied degradation of its inhibitor, IκBα, contributes to efficient transcription of both genes following SD. We show that following serum starvation, delayed up-regulation of miR-9 represses translation of CD166 protein through its target sites in the 3′-UTR of CD166 mRNA. We also propose that miR-9 promotes cell migration largely due to inhibition of CD166. Collectively, the study elucidates a novel negative auto-regulatory loop in which NF-κB mediates differential regulation of CD166 after SD
Metamagnetic transition in EuFeAs single crystals
We report the measurements of anisotropic magnetization and magnetoresistance
on single crystals of EuFeAs, a parent compound of ferro-arsenide
high-temperature superconductor. Apart from the antiferromagnetic (AFM)
spin-density-wave transition at 186 K associated with Fe moments, the compound
undergoes another magnetic phase transition at 19 K due to AFM ordering of
Eu spins (). The latter AFM state exhibits metamagnetic
transition under magnetic fields. Upon applying magnetic field with at 2 K, the magnetization increases linearly to 7.0 /f.u. at
=1.7 T, then keeps at this value of saturated Eu moments under
higher fields. In the case of , the magnetization increases
step-like to 6.6 /f.u. with small magnetic hysteresis. A metamagnetic
phase was identified with the saturated moments of 4.4 /f.u. The
metamagnetic transition accompanies with negative in-plane magnetoresistance,
reflecting the influence of Eu moments ordering on the electrical
conduction of FeAs layers. The results were explained in terms of
spin-reorientation and spin-reversal based on an -type AFM structure for
Eu spins. The magnetic phase diagram has been established.Comment: 10 pages, 8 figures. accepted for publication in New Journal of
Physics as a special issue articl
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma. PDX have been characterized using targeted sequencing and protein arrays and are clinically annotated. This exhaustive live tissue resource includes PDX from 57 samples resistant to targeted therapy, 61 samples from responders and non-responders to immune checkpoint blockade, and 31 samples from brain metastasis. Uveal, mucosal, and acral subtypes are represented as well. We show examples of pre-clinical trials that highlight how the PDX collection can be used to develop and optimize precision therapies, biomarkers of response, and the targeting of rare genetic subgroups
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