49 research outputs found
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders
Changes in genetic and/or environmental factors to developing neural circuits
and subsequent synaptic functions are known to be a causative underlying the
varied socio-emotional behavioural patterns associated with autism spectrum
disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs)
comprising the largest family of cell-surface receptors, mediate the transfer
of extracellular signals to downstream cellular responses. Disruption of GPCR
and their signalling have been implicated as a convergent pathologic mechanism
of ASD. Here, we aim to review the literature about the 23 GPCRs that are
genetically associated to ASD pathology according to Simons Foundation Autism
Research Initiative (SFARI) database such as oxytocin (OXTR) and vasopressin
(V1A, V1B) receptors, metabotropic glutamate (mGlu5, mGlu7) and
gamma-aminobutyric acid (GABAB) receptors, dopamine (D1, D2), serotoninergic
(5-HT1B and additionally included the 5-HT2A, 5-HT7 receptors for their strong
relevance to ASD), adrenergic (2) and cholinergic (M3) receptors,
adenosine (A2A, A3) receptors, angiotensin (AT2) receptors, cannabinoid (CB1)
receptors, chemokine (CX3CR1) receptors, orphan (GPR37, GPR85) and olfactory
(OR1C1, OR2M4, OR2T10, OR52M1) receptors. We discussed the genetic variants,
relation to core ASD behavioural deficits and update on pharmacological
compounds targeting these 23 GPCRs. Of these OTR, V1A, mGlu5, D2, 5-HT2A, CB1,
and GPR37 serve as the best therapeutic targets and have potential towards core
domains of ASD pathology. With a functional crosstalk between different GPCRs
and converging pharmacological responses, there is an urge to develop novel
therapeutic strategies based on multiple GPCRs to reduce the socioeconomic
burden associated with ASD and we strongly emphasize the need to prioritize the
increased clinical trials targeting the multiple GPCRs
Hybrid Regional Aircraft: A Comparative Review of New Potentials Enabled by Electric Power
This article assesses the benefits of hybridization within the regional aircraft scale using a conventional twin-turbo propeller aircraft as reference. For a fair comparison, this reference aircraft was designed assuming a 2035 technology level. The propulsion system of the reference aircraft is analyzed along the mission and the phases of flight with low efficiencies are highlighted. Then the potential benefits of new power management through the use of secondary power generation systems but also through the variation of the size of prime movers are presented and discussed. In particular, the effect of the gas turbine size on its efficiency is studied. Finally, the article focuses on aerodynamic improvements enabled by new propeller or fan integrations and the associated concepts such as differential thrust, blown wing and boundary layer ingestion. For each topic, simplified analyses provide estimated potential of energy saving. These results can be used as indicators for selecting the most promising hybrid architecture concepts for a regional aircraft
Hybrid Propulsion for Regional Aircraft: a Comparative Analysis based on Energy Efficiency
This article assesses the potential benefits of transient energy storage for a hybrid regional aircraft. The mission profile of a reference aircraft is analyzed according to energetic intermittence and the results are compared to typical figures for cars, trains, and ships. Also, the opportunity of recovering energy in descent and during landing is studied. This article shows that energy saving potential brought by transient energy storage is much smaller than for ground-based transportation. In addition, energy recovering does not bring benefit on a hybrid aircraft in normal operation. Nevertheless, the best energy management strategies in descent are highlighted and the use of a hybrid propulsion system in this phase shows significant potential energy savings. Finally, the article addresses other strategies enabled by hybrid propulsion to improve the aircraft energy efficiency
Bringing up to date the French database of nuclear workers contaminated with plutonium and/or americium and treated with Ca-DTPA
Hybrid Regional Aircraft: A Comparative Review of New Potentials Enabled by Electric Power
International audienceThis article assesses the benefits of hybridization within the regional aircraft scale using a conventional twin-turbo propeller aircraft as reference. For a fair comparison, this reference aircraft was designed assuming a 2035 technology level. The propulsion system of the reference aircraft is analyzed along the mission and the phases of flight with low efficiencies are highlighted. Then the potential benefits of new power management through the use of secondary power generation systems but also through the variation of the size of prime movers are presented and discussed. In particular, the effect of the gas turbine size on its efficiency is studied. Finally, the article focuses on aerodynamic improvements enabled by new propeller or fan integrations and the associated concepts such as differential thrust, blown wing and boundary layer ingestion. For each topic, simplified analyses provide estimated potential of energy saving. These results can be used as indicators for selecting the most promising hybrid architecture concepts for a regional aircraft
Hybrid Regional Aircraft: A Comparative Review of New Potentials Enabled by Electric Power
International audienceThis article assesses the benefits of hybridization within the regional aircraft scale using a conventional twin-turbo propeller aircraft as reference. For a fair comparison, this reference aircraft was designed assuming a 2035 technology level. The propulsion system of the reference aircraft is analyzed along the mission and the phases of flight with low efficiencies are highlighted. Then the potential benefits of new power management through the use of secondary power generation systems but also through the variation of the size of prime movers are presented and discussed. In particular, the effect of the gas turbine size on its efficiency is studied. Finally, the article focuses on aerodynamic improvements enabled by new propeller or fan integrations and the associated concepts such as differential thrust, blown wing and boundary layer ingestion. For each topic, simplified analyses provide estimated potential of energy saving. These results can be used as indicators for selecting the most promising hybrid architecture concepts for a regional aircraft
Risk of relapse after COVID-19 vaccine among patients with multiple sclerosis in France: a self-controlled case series
International audienc
Risk of relapse after COVID-19 vaccine among patients with multiple sclerosis in France: a self-controlled case series
International audienc
Risk of relapse after COVID-19 vaccine among patients with multiple sclerosis in France: a self-controlled case series
International audienc
Cancer risk among patients with MS : a 10-year nationwide cohort study using the French medico-administrative database (2012-2021)
International audienc