The Deep and Transient Universe in the SVOM Era: New Challenges and Opportunities - Scientific prospects of the SVOM mission

To take advantage of the astrophysical potential of Gamma-Ray Bursts (GRBs), Chinese and French astrophysicists have engaged the SVOM mission (Space-based multi-band astronomical Variable Objects Monitor). Major advances in GRB studies resulting from the synergy between space and ground observations, the SVOM mission implements space and ground instrumentation. The scientific objectives of the mission put a special emphasis on two categories of GRBs: very distant GRBs at z$>$5 which constitute exceptional cosmological probes, and faint/soft nearby GRBs which allow probing the nature of the progenitors and the physics at work in the explosion. These goals have a major impact on the design of the mission: the on-board hard X-ray imager is sensitive down to 4 keV and computes on line image and rate triggers, and the follow-up telescopes on the ground are sensitive in the NIR. At the beginning of the next decade, SVOM will be the main provider of GRB positions and spectral parameters on very short time scale. The SVOM instruments will operate simultaneously with a wide range of powerful astronomical devices. This rare instrumental conjunction, combined with the relevance of the scientific topics connected with GRB studies, warrants a remarkable scientific return for SVOM. In addition, the SVOM instrumentation, primarily designed for GRB studies, composes a unique multi-wavelength observatory with rapid slew capability that will find multiple applications for the whole astronomy community beyond the specific objectives linked to GRBs. This report lists the scientific themes that will benefit from observations made with SVOM, whether they are specific GRB topics, or more generally all the issues that can take advantage of the multi-wavelength capabilities of SVOM

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance