661 research outputs found
Quantum Brayton cycle with coupled systems as working substance
We explore the quantum version of Brayton cycle with a composite system as
the working substance. The actual Brayton cycle consists of two adiabatic and
two isobaric processes. Two pressures can be defined in our isobaric process,
one corresponds to the external magnetic field (characterized by ) exerted
on the system, while the other corresponds to the coupling constant between the
subsystems (characterized by ). As a consequence, we can define two types
of quantum Brayton cycle for the composite system. We find that the subsystem
experiences a quantum Brayton cycle in one quantum Brayton cycle (characterized
by ), whereas the subsystem's cycle is of quantum Otto in another Brayton
cycle (characterized by ). The efficiency for the composite system equals
to that for the subsystem in both cases, but the work done by the total system
are usually larger than the sum of work done by the two subsystems. The other
interesting finding is that for the cycle characterized by , the subsystem
can be a refrigerator while the total system is a heat engine. The result in
the paper can be generalized to a quantum Brayton cycle with a general coupled
system as the working substance.Comment: 7 pages, 3 figures, accepted by Phys. Rev.
Integrable motion of a vortex dipole in an axisymmetric flow
The evolution of a self-propelling vortex dipole, embedded in an external nondivergent flow with constant potential vorticity, is studied in an equivalent-barotropic model commonly used in geophysical, astrophysical and plasma studies. In addition to the conservation of the Hamiltonian for an arbitrary point vortex dipole, it is found that the angular momentum is also conserved when the external flow is axisymmetric. This reduces the original four degrees of freedom to only two, so that the solution is expressed in quadratures. In particular, the scattering of antisymmetric dipoles approaching from the infinity is analyzed in the presence of an axisymmetric oceanic flow typical for the vicinity of isolated seamounts
Three-dimensional lattice-Boltzmann simulations of critical spinodal decomposition in binary immiscible fluids
We use a modified Shan-Chen, noiseless lattice-BGK model for binary
immiscible, incompressible, athermal fluids in three dimensions to simulate the
coarsening of domains following a deep quench below the spinodal point from a
symmetric and homogeneous mixture into a two-phase configuration. We find the
average domain size growing with time as , where increases
in the range , consistent with a crossover between
diffusive and hydrodynamic viscous, , behaviour. We find
good collapse onto a single scaling function, yet the domain growth exponents
differ from others' works' for similar values of the unique characteristic
length and time that can be constructed out of the fluid's parameters. This
rebuts claims of universality for the dynamical scaling hypothesis. At early
times, we also find a crossover from to in the scaled structure
function, which disappears when the dynamical scaling reasonably improves at
later times. This excludes noise as the cause for a behaviour, as
proposed by others. We also observe exponential temporal growth of the
structure function during the initial stages of the dynamics and for
wavenumbers less than a threshold value.Comment: 45 pages, 18 figures. Accepted for publication in Physical Review
Collective excitations in double-layer quantum Hall systems
We study the collective excitation spectra of double-layer quantum-Hall
systems using the single mode approximation. The double-layer in-phase density
excitations are similar to those of a single-layer system. For out-of-phase
density excitations, however, both inter-Landau-level and intra-Landau-level
double-layer modes have finite dipole oscillator strengths. The oscillator
strengths at long wavelengths for the latter transitions are shifted upward by
interactions by identical amounts proportional to the interlayer Coulomb
coupling. The intra-Landau-level out-of-phase mode has a gap when the ground
state is incompressible except in the presence of spontaneous inter-layer
coherence. We compare our results with predictions based on the
Chern-Simons-Landau-Ginzburg theory for double-layer quantum Hall systems.Comment: RevTeX, 21 page
Anti-CD38 antibody therapy for patients with relapsed/refractory multiple myeloma: differential mechanisms of action and recent clinical trial outcomes.
CD38 is a transmembrane glycoprotein that functions both as a receptor and an ectoenzyme, playing key roles in the regulation of calcium signaling and migration of immune cells to tumor microenvironments. High expression on multiple myeloma (MM) cells and limited expression on normal cells makes CD38 an ideal target for the treatment of MM patients. Two monoclonal antibodies directed at CD38, isatuximab and daratumumab, are available for use in patients with relapsed and/or refractory MM (RRMM); daratumumab is also approved in newly diagnosed MM and light-chain amyloidosis. Clinical experience has shown that anti-CD38 antibody therapy is transforming treatment of MM owing to its anti-myeloma efficacy and manageable safety profile. Isatuximab and daratumumab possess similarities and differences in their mechanisms of action, likely imparted by their binding to distinct, non-overlapping epitopes on the CD38 molecule. In this review, we present the mechanistic properties of these two antibodies and outline available evidence on their abilities to induce adaptive immune responses and modulate the bone marrow niche in MM. Further, we discuss differences in regulatory labeling between these two agents and analyze recent key clinical trial results, including evidence in patients with underlying renal impairment and other poor prognostic factors. Finally, we describe the limited existing evidence for the use of isatuximab or daratumumab after disease progression on prior anti-CD38 mono- or combination therapy, highlighting the need for additional clinical evaluations to define optimal anti-CD38 antibody therapy selection and sequencing in RRMM
Measurement of double beta decay of ¹⁰⁰Mo to excited states in the NEMO 3 experiment
The double beta decay of ¹⁰⁰Mo to the 0_{1}^{+} and 2_{1}^{+} excited states of ¹⁰⁰Ru is studied using the NEMO 3 data. After the analysis of 8024 h of data the half-life for the two-neutrino double beta decay of ¹⁰⁰Mo to the excited 0_{1}^{+} state is measured to be T_{1/2}^{2v} = [5.7_{-0.9}^{+1.3} (stat.) ± 0.8 (syst.)] x 10²⁰ y. The signal-to-background ratio is equal to 3. Information about energy and angular distributions of emitted electrons is also obtained. No evidence for neutrinoless double beta decay to the excited 0_{1}^{+} state has been found. The corresponding half-life limit is T_{1/2}^{0v} (0⁺→0_{1}^{+}) > 8.9 x 10²² y (at 90% C.L.). The search for the double beta decay to the 2_{1}^{+} excited state has allowed the determination of limits on the half-life for the two neutrino mode T_{1/2}^{0v} (0⁺→2_{1}^{+}) > 1.1 x 10²¹ y (at 90% C.L.) and for the neutrinoless mode T_{1/2}^{0v} (0⁺→2_{1}^{+}) > 1.6 x 10²³ y (at 90% C.L.)
Noncommutative Topological Theories of Gravity
The possibility of noncommutative topological gravity arising in the same
manner as Yang-Mills theory is explored. We use the Seiberg-Witten map to
construct such a theory based on a SL(2,C) complex connection, from which the
Euler characteristic and the signature invariant are obtained. This gives us a
way towards the description of noncommutative gravitational instantons as well
as noncommutative local gravitational anomalies.Comment: 17+1 pages, LaTeX, no figures, some clarifications, comments and
references added, style improve
Spontaneous Inter-layer Coherence in Double-Layer Quantum-Hall Systems I: Charged Vortices and Kosterlitz-Thouless Phase Transitions
At strong magnetic fields double-layer two-dimensional-electron-gas systems
can form an unusual broken symmetry state with spontaneous inter-layer phase
coherence. In this paper we explore the rich variety of quantum and
finite-temperature phase transitions associated with this broken symmetry. We
describe the system using a pseudospin language in which the layer
degree-of-freedom is mapped to a fictional spin 1/2 degree-of-freedom. With
this mapping the spontaneous symmetry breaking is equivalent to that of a spin
1/2 easy-plane ferromagnet. In this language spin-textures can carry a charge.
In particular, vortices carry e/2 electrical charge and vortex-antivortex pairs
can be neutral or carry charge e. We derive an effective low-energy action and
use it to discuss the charged and collective neutral excitations of the system.
We have obtained the parameters of the Landau-Ginzburg functional from
first-principles estimates and from finite-size exact diagonalization studies.
We use these results to estimate the dependence of the critical temperature for
the Kosterlitz-Thouless phase transition on layer separation.Comment: 56 pages, 19 figures available upon request at
[email protected]. RevTex 3.0. IUCM94-00
Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils
The development of BiPo detectors is dedicated to the measurement of
extremely high radiopurity in Tl and Bi for the SuperNEMO
double beta decay source foils. A modular prototype, called BiPo-1, with 0.8
of sensitive surface area, has been running in the Modane Underground
Laboratory since February, 2008. The goal of BiPo-1 is to measure the different
components of the background and in particular the surface radiopurity of the
plastic scintillators that make up the detector. The first phase of data
collection has been dedicated to the measurement of the radiopurity in
Tl. After more than one year of background measurement, a surface
activity of the scintillators of (Tl) 1.5
Bq/m is reported here. Given this level of background, a larger BiPo
detector having 12 m of active surface area, is able to qualify the
radiopurity of the SuperNEMO selenium double beta decay foils with the required
sensitivity of (Tl) 2 Bq/kg (90% C.L.) with a six
month measurement.Comment: 24 pages, submitted to N.I.M.
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