560 research outputs found
Controversial Issues in Adventure Education
The book, Controversial Issues in Adventure Education, will address some of the most controversial topics in the field of adventure education. It will consist of 15 questions set up in a debate format where adventure education professional will present opposing viewpoints on each issue
Undergraduate Sport Management Studentsā Perceptions of Leadership Skills Through Service Learning
Researchers have discovered that service learning affects studentsā academic, personal, and social development. However, currently there is a gap in literature analyzing ways in which service learning affects studentsā perceived leadership skills. This study examined the effectiveness of service learning on the perceived leadership skills of 74 sport management undergraduate students at a mid-sized, Midwestern, public university using Kouzesā and Posnerās Student Leadership Practices Inventory instrument, which examines leadership practices in five areas: Model the Way, Inspire a Shared Vision, Challenge the Process, Enable Others to Act, and Encourage the Heart. The results of this study may help faculty members and administrators to better understand the potential of utilizing service learning projects in their classrooms as a vehicle for their students to develop quality leadership practices. Recommendations for further research and practice are also discussed
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Healing of myocardial infarction (MI) requires monocytes/macrophages. These mononuclear phagocytes likely degrade released macromolecules and aid in scavenging of dead cardiomyocytes, while mediating aspects of granulation tissue formation and remodeling. The mechanisms that orchestrate such divergent functions remain unknown. In view of the heightened appreciation of the heterogeneity of circulating monocytes, we investigated whether distinct monocyte subsets contribute in specific ways to myocardial ischemic injury in mouse MI. We identify two distinct phases of monocyte participation after MI and propose a model that reconciles the divergent properties of these cells in healing. Infarcted hearts modulate their chemokine expression profile over time, and they sequentially and actively recruit Ly-6Chi and -6Clo monocytes via CCR2 and CX3CR1, respectively. Ly-6Chi monocytes dominate early (phase I) and exhibit phagocytic, proteolytic, and inflammatory functions. Ly-6Clo monocytes dominate later (phase II), have attenuated inflammatory properties, and express vascularāendothelial growth factor. Consequently, Ly-6Chi monocytes digest damaged tissue, whereas Ly-6Clo monocytes promote healing via myofibroblast accumulation, angiogenesis, and deposition of collagen. MI in atherosclerotic mice with chronic Ly-6Chi monocytosis results in impaired healing, underscoring the need for a balanced and coordinated response. These observations provide novel mechanistic insights into the cellular and molecular events that regulate the response to ischemic injury and identify new therapeutic targets that can influence healing and ventricular remodeling after MI
Decision making and risk management in adventure sports coaching
Adventure sport coaches practice in environments that are dynamic and high in risk, both perceived and actual. The inherent risks associated with these activities, individualsā responses and the optimal exploitation of both combine to make the processes of risk management more complex and hazardous than the traditional sports where risk management is focused almost exclusively on minimization. Pivotal to this process is the adventure sports coachesā ability to make effective judgments regarding levels of risk, potential benefits and possible consequences. The exact nature of this decision making process should form the basis of coaching practice and coach education in this complex and dynamic field. This positional paper examines decision making by the adventure sports coach in these complex, challenging environments and seeks to stimulate debate whilst offering a basis for future research into this topic
The Right Place at the Right Time: Creative Spaces in Libraries
Purpose
This essay explores the recent trend in libraries: that of the establishment of spaces specifically set aside for creative work. The rise of these dedicated creative spaces is owed to a confluence of factors that happen to be finding their expression together in recent years. This essay examines the history of these spaces and explores the factors that gave rise to them and will fuel them moving forward.
Design/Methodology/Approach
A viewpoint piece, this essay combines historical research and historical/comparative analyses to examine the ways by which libraries have supported creative work in the past and how they may continue to do so into the 21st century.
Findings
The key threads brought together include a societal recognition of the value of creativity and related skills and attributes; the philosophies, values, and missions of libraries in both their longstanding forms and in recent evolutions; the rise of participatory culture as a result of inexpensive technologies; improved means to build community and share results of efforts; and library experience and historical practice in matters related to creativity. The chapter concludes with advice for those interested in the establishment of such spaces, grounding those reflections in the authorās experiences in developing a new creative space at Virginia Commonwealth University.
Originality/value
While a number of pieces have been written that discuss the practicalities of developing certain kinds of creative spaces, very little has been written that situates these spaces in larger social and library professional contexts; this essay begins to fill that gap
Pubic bone injuries in primiparous women: magnetic resonance imaging in detection and differential diagnosis of structural injury
Objective To evaluate the utility of magnetic resonance imaging (MRI) in diagnosing structural injury in primiparous women at risk for pelvic floor injury. Methods This was an observational study of 77 women who underwent 3T MRI after delivery. Women were operationally defined as high risk ( n = 45) for levator ani muscle tears (risk factors: secondāstage labor > 150 min or 35 years and birth weight > 4000 g) or low risk ( n = 32): vaginally delivered without these risk factors ( n = 12); delivered by Cesarean section after secondāstage labor > 150 min ( n = 14) or delivered by Cesarean section without labor ( n = 6). All women were imaged using fluidāsensitive MRI sequences. Two musculoskeletal radiologists reviewed images for bone marrow edema, fracture, pubic symphysis measurements and levator ani tear. Results MRI showed pubic bone fractures in 38% of women at high risk for pelvic floor injury and in 13% of women at low risk for pelvic floor injury (Ļ 2 (3) = 9.27, P = 0.03). Levator ani muscle tears were present in 44% of the highārisk women and in 9% of the lowārisk women (Ļ 2 (3) = 11.57, P = 0.010). Bone marrow edema in the pubic bones was present in 61% of women studied across delivery categories. Complex patterns of injury included combinations of bone marrow edema, fractures, levator ani tears and pubic symphysis injuries. No MRIādocumented injuries were present in 18% of women at high risk and 44% at low risk for pelvic floor injury (Ļ 2 (1) = 6.2, P = 0.013). Conclusions Criteria identifying primiparous women at risk for pelvic floor injury can predict increased risk of bone and soft tissue changes at the pubic symphysis. Fluidāsensitive MRI has utility for differential diagnosis of structural injury in postpartum women. Copyright Ā© 2012 ISUOG. Published by John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90593/1/9082_ftp.pd
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Liquid biopsies in patients with diffuse glioma
Diffuse gliomas are the most common malignant primary tumors of the central nervous system. Like other neoplasms, these gliomas release molecular information into the circulation. Tumor-derived biomarkers include proteins, nucleic acids, and tumor-derived extracellular vesicles that accumulate in plasma, serum, blood platelets, urine and/or cerebrospinal fluid. Recently, also circulating tumor cells have been identified in the blood of glioma patients. Circulating molecules, vesicles, platelets, and cells may be useful as easily accessible diagnostic, prognostic and/or predictive biomarkers to guide patient management. Thereby, this approach may help to circumvent problems related to tumor heterogeneity and sampling error at the time of diagnosis. Also, liquid biopsies may allow for serial monitoring of treatment responses and of changes in the molecular characteristics of gliomas over time. In this review, we summarize the literature on blood-based biomarkers and their potential value for improving the management of patients with a diffuse glioma. Incorporation of the study of circulating molecular biomarkers in clinical trials is essential for further assessment of the potential of liquid biopsies in this context. Electronic supplementary material The online version of this article (doi:10.1007/s00401-015-1399-y) contains supplementary material, which is available to authorized users
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