BIOINFORMATIC ANALYSIS OF PROTEOMIC AND GENOMIC DATA FROM NSCLC TUMORS ON PROGNOSTIC AND PREDICTIVE FACTORS OF IMMUNOTHERAPY TREATMENT

Recent lung cancer research has led to advancements in molecular immunology, resulting in development of small molecule inhibitors, or immune checkpoint inhibitors, that propagate an anti-tumor T cell response. Despite increased overall and progression-free survival with reduced adverse effects compared to traditional chemotherapy, treating advanced stage lung adenocarcinoma patients remains non-curative, and evidence of non-responders or tumor recurrence to immune checkpoint inhibitor therapy is growing. Also, compared to traditional chemotherapy, there is a lower percentage of patients who respond to small molecule inhibitors. In this analysis of proteomic and genomic data from The Cancer Proteome Atlas and Global Data Commons cancer databases, as well as clinical outcomes data from Phase II POPLAR and Phase III OAK clinical trials, we discuss possible prognostic and predictive factors of immunotherapy in the treatment of advanced non-small-cell lung carcinoma

The Grizzly, April 4, 1985

This is an April Fool\u27s satire issue of the Grizzly newspaper entitled Instead of The Grizzly.https://digitalcommons.ursinus.edu/grizzlynews/1138/thumbnail.jp

Asymmetry Dependence of the Nuclear Caloric Curve

A basic feature of the nuclear equation of state is not yet understood: the dependence of the nuclear caloric curve on the neutron-proton asymmetry. Predictions of theoretical models differ on the magnitude and even the sign of this dependence. In this work, the nuclear caloric curve is examined for fully reconstructed quasi-projectiles around mass A=50. The caloric curve extracted with the momentum quadrupole fluctuation thermometer shows that the temperature varies linearly with quasi-projectile asymmetry (N-Z)/A. An increase in asymmetry of 0.15 units corresponds to a decrease in temperature on the order of 1 MeV. These results also highlight the importance of a full quasi-projectile reconstruction in the study of thermodynamic properties of hot nuclei

Measuring the Temperature of Hot Nuclear Fragments

A new thermometer based on fragment momentum fluctuations is presented. This thermometer exhibited residual contamination from the collective motion of the fragments along the beam axis. For this reason, the transverse direction has been explored. Additionally, a mass dependence was observed for this thermometer. This mass dependence may be the result of the Fermi momentum of nucleons or the different properties of the fragments (binding energy, spin etc..) which might be more sensitive to different densities and temperatures of the exploding fragments. We expect some of these aspects to be smaller for protons (and/or neutrons); consequently, the proton transverse momentum fluctuations were used to investigate the temperature dependence of the source

Three-dimensional subsurface imaging synthetic aperture radar

Inadequate resources, aggravated by the limited capabilities of existing site characterization technologies, require that new systems be developed to effectively aid site cleanup. The quantity, condition, and the precise location of buried waste storage containers is often unknown, and is always difficult to assess. Significant safety hazards may also be present at these sites. Therefore, new non-invasive detection techniques are needed that will be cost effective, user friendly, and have a growth path toward a system capable of accessing remote terrain. These detection methods must be economical to use and be capable of exploring large land areas quickly with minimal personnel risk. They should provide the precision for identifying the size, depth, type, and possibly the condition of the waste containers

Nucleation and cluster formation in low-density nucleonic matter: A mechanism for ternary fission

Ternary fission yields in the reaction 241Pu(nth,f) are calculated using a new model which assumes a nucleation-time moderated chemical equilibrium in the low density matter which constitutes the neck region of the scissioning system. The temperature, density, proton fraction and fission time required to fit the experimental data are derived and discussed. A reasonably good fit to the experimental data is obtained. This model provides a natural explanation for the observed yields of heavier isotopes relative to those of the lighter isotopes, the observation of low proton yields relative to 2H and 3H yields and the non-observation of 3He, all features which are shared by similar thermal neutron induced and spontaneous fissioning systems.Comment: 6 pages, 3 figure

Forty Years of Change in Piute Cypress (Hesperocyparis nevadensis), a Rare California Tree, After Frequent Fire and Drought

Piute cypress (Hesperocyparis nevadensis) is a rare cypress species endemic to the Lake Isabella region in the southern Sierra Nevada in California. Piute cypress groves have not been quantitatively studied in the last 40 years and with recent fires (some in short succession) and observed mortality, we had questions surrounding conditions in groves recovering from fire compared to other groves with no recorded fire histories. Piute cypress rarely survive fire and are obligate seeders with serotinous cones and, as such, require sufficient time after fire to grow to reproductive maturity to be able to withstand future fire. We visited five of the 12 known groves of Piute cypress to evaluate current stand conditions and make comparisons with an assessment conducted 40 years ago. We evaluated two recently burned groves nine years post-fire. One grove with a shorter interval between fires (~20 years), has only limited regeneration and is at risk of local extinction. Based on our findings, we extrapolated to unstudied groves to conclude that five recently burned groves are vulnerable to immaturity risk if these stands were to reburn soon. We recommend aggressive fire suppression tactics to protect these groves if threatened by fire. Another recently burned grove with a longer period between fires (~90 years) appears to be recovering and capable of becoming a self-sustaining population that can survive another fire based on regeneration data. While the 90-year-old trees did not have nearly the level of canopy seed bank that older trees (~200 years old) did in another part of the grove, seedling and sapling regeneration after fire occurred at higher densities than tree densities in mature stands and were already developing cones. Though theoretically long-unburned groves also may be at risk, we found no evidence of age-related decline in this long-lived species and some non-fire induced regeneration. We did discover evidence of cedar bark beetle attack (Phloeosinus), particularly in smaller trees at two unburned groves. which was correlated to high tree mortality (31.6%) at one site. While we found no evidence of encroaching non-cypress tree species threatening long-unburned groves among mature cohorts, we did document relatively high densities of regenerating non-cypress tree species in groves. We strongly recommend further monitoring in groves to assess fire, insect, and disease vulnerability in cypress populations

The Grizzly, March 22, 1985

WVOU to Broadcast to Wismer • U.C. Receives $32,000 in Grants • Letter: Thoughtless Student Hurts Feelings • New Faces, New Places • Woman\u27s Club Events • Independent Eye Stages Macbeth • Meistersingers to Present Spring Program • Stevenson Resigns as Golf Coachhttps://digitalcommons.ursinus.edu/grizzlynews/1136/thumbnail.jp