Principles and Practices Report on Online Enrichment and Extension for the Gifted and Talented

Based on analysis of the individual characteristics and needs of gifted and talented students, this report gives a brief discussion of the attributes of online enrichment and extension to support quick learners. A conceptual framework for the structure and processes of good online enrichment and extension will also be explained. Key words: attributes; online enrichment and extension; the gifted and talented Résumé: Basé sur les analyses des caractères individuels et des besoins des étudiants doués et talentueux, ce rapport nous donne une discussion brève sur les attributs de l’enrichissement et de l’extension en ligne en tant qu’un support pour les débutants rapides. Le cadre conceptuel pour la structure et les processus de l’enrichissement et de l’extension en lighe sera également expliqué dans cet article . Mots-Clés: attributs; enrishissement et extension en ligne; les doués et les talentueu

Ω−\Omega^- production as a probe of equation of state of dense matter near the QCD phase transition in relativistic heavy-ion collisions

Based on a relativistic transport model coupled with hadronic mean-field potentials for heavy-ion collisions, the productions of doubly strange hyperon $\Xi^-$ and trebly strange hyperon $\Omega^-$ in relativistic Au+Au collisions at $\sqrt{s_{NN}}$ = 4.2 GeV are investigated. Compared with the double strangeness sensitive observable $\Xi^-$, the treble strangeness $\Omega^-$, whether its yields or its collective flows, is extremely sensitive to the equation of state (EoS) of dense matter, making it a valuable observable for probing the properties of dense matter formed in relativistic heavy-ion collisions.Comment: 5 pages, 5 figure

N-[3-(Dimethyl­amino)­prop­yl]-N′-(2-hy­droxy-5-methyl­phen­yl)oxamide

In the title compound, C14H21N3O3, the oxamide group has a transoid conformation. In the crystal, the mol­ecules are connected by N—H⋯O and O—H⋯N hydrogen bonds into a double chain running along the b axis

Genome-wide association analysis identifies resistance loci for bacterial blight in a diverse collection of indica rice germplasm

Bacterial blight, which is caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the most devastating rice diseases worldwide. The development and use of disease-resistant cultivars have been the most effective strategy to control bacterial blight. Identifying the genes mediating bacterial blight resistance is a prerequisite for breeding cultivars with broad-spectrum and durable resistance. We herein describe a genome-wide association study involving 172 diverse Oryza sativa ssp. indica accessions to identify loci influencing the resistance to representative strains of six Xoo races. Twelve resistance loci containing 121 significantly associated signals were identified using 317,894 single nucleotide polymorphisms, which explained 13.3–59.9% of the variability in lesion length caused by Xoo races P1, P6, and P9a. Two hotspot regions (L11 and L12) were located within or nearby two cloned R genes (xa25 and Xa26) and one fine-mapped R gene (Xa4). Our results confirmed the relatively high resolution of genome-wide association studies. Moreover, we detected novel significant associations on chromosomes 2, 3, and 6–10. Haplotype analyses of xa25, the Xa26 paralog (MRKc; LOC_Os11g47290), and a Xa4 candidate gene (LOC_11g46870) revealed differences in bacterial blight resistance among indica subgroups. These differences were responsible for the observed variations in lesion lengths resulting from infections by Xoo races P1 and P9a. Our findings may be relevant for future studies involving bacterial blight resistance gene cloning, and provide insights into the genetic basis for bacterial blight resistance in indica rice, which may be useful for knowledge-based crop improvement. (Résumé d'auteur

Redetermined structure of oxaline: absolute configuration using Cu Kα radiation

In the title compound, C24H25N5O4, the stereogenic C atom bonded to three N atoms and one C atom has an S configuration and its directly bonded neighbour has an R configuration. An intra­molecular N—H⋯O hydrogen bond supports the near coplanarity of the two C3N2-five-membered rings [dihedral angle = 5.64 (10)°]. In the crystal, mol­ecules are linked by N—H⋯N hydrogen bonds, forming a C(8) chain propagating in [001]. The chains are connected by C—H⋯O inter­actions, generating a three-dimensional network. The previous study [Nagel et al. (1974 ▶). Chem. Commun. pp. 1021–1022] did not establish the absolute structure and no atomic coordinates were published or deposited

Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats.

Background: A previous study found that brain natriuretic peptide (BNP) inhibited inflammatory pain via activating its receptor natriuretic peptide receptor A (NPRA) in nociceptive sensory neurons. A recent study found that functional NPRA is expressed in almost all the trigeminal ganglion (TG) neurons at membrane level suggesting a potentially important role for BNP in migraine pathophysiology. Methods: An inflammatory pain model was produced by subcutaneous injection of BmK I, a sodium channel-specific modulator from venom of Chinese scorpion Buthus martensi Karsch. Quantitative PCR, Western Blot, and immunohistochemistry were used to detect mRNA and protein expression of BNP and NPRA in dorsal root ganglion (DRG) and dorsal horn of spinal cord. Whole-cell patch clamping experiments were conducted to record large-conductance Ca2+-activated K+ (BKCa) currents of membrane excitability of DRG neurons. Spontaneous and evoked pain behaviors were examined. Results: The mRNA and protein expression of BNP and NPRA was up-regulated in DRG and dorsal horn of spinal cord after BmK I injection. The BNP and NPRA was preferentially expressed in small-sized DRG neurons among which BNP was expressed in both CGRP-positive and IB4-positive neurons while NPRA was preferentially expressed in CGRP-positive neurons. BNP increased the open probability of BKCa channels and suppressed the membrane excitability of small-sized DRG neurons. Intrathecal injection of BNP significantly inhibited BmK-induced pain behaviors including both spontaneous and evoked pain behaviors. Conclusions: These results suggested that BNP might play an important role as an endogenous pain reliever in BmK I-induced inflammatory pain condition. It is also suggested that BNP might play a similar role in other pathophysiological pain conditions including migraine

Research on the Running Speed Prediction Model of Interchange Ramp

AbstractRamp is an important part of the interchange. The ramp design concept based on the running speed is a new design idea of the highway and interchange. By analysis of the influence factors of the interchange ramp running speed, this paper formulates the orthogonal experiment, and collects 14 ramps, in total of 147 groups of the running speed as the samples, and then analyzes the characteristics of the running speed of the vehicles on interchange ramp. According to the change trend of the running speed, the ramp is divided into three sections: deceleration section, uniform section, acceleration section. This paper mainly analyzes the relationship between the interchange ramp running speed of the three sections and the influence factors; and then this paper builds the interchange ramp running speed prediction model of the three sections. At last, correlation test will be validated, and verify the applicability of the model

Revisiting the Pion Leading-Twist Distribution Amplitude within the QCD Background Field Theory

We study the pion leading-twist distribution amplitude (DA) within the framework of SVZ sum rules under the background field theory. To improve the accuracy of the sum rules, we expand both the quark propagator and the vertex (z\cdot \tensor{D})^n of the correlator up to dimension-six operators in the background field theory. The sum rules for the pion DA moments are obtained, in which all condensates up to dimension-six have been taken into consideration. Using the sum rules, we obtain \left|_{\rm 1\;GeV} = 0.338 \pm 0.032, \left|_{\rm 1\;GeV} = 0.211 \pm 0.030 and \left|_{\rm 1\;GeV} = 0.163 \pm 0.030. It is shown that the dimension-six condensates shall provide sizable contributions to the pion DA moments. We show that the first Gegenbauer moment of the pion leading-twist DA is $a^\pi_2|_{\rm 1\;GeV} = 0.403 \pm 0.093$, which is consistent with those obtained in the literature within errors but prefers a larger central value as indicated by lattice QCD predictions.Comment: 13 pages, 7 figure