The Implementation of Flipped Classroom in Efl Class: a Taiwan Case Study

This article reports on a case study designed to examine the implementation of flipped classroom in the EFL classroom in Taiwan.  In addition, students' perception of flipped classroom was also investigated. Sixty-one senior high school students participated in this study; data were gathered from students' English midterm exam score and questionnaire. The data then were quantitatively analyzed by using T-test and descriptive statistics. The results show that students' English proficiency in flipped classroom was not significantly different with students in traditional classroom. However, the results reveal that students' perception of flipped classroom were generally favorable. Students' contended that flipped classroom enhanced their motivation in learning English, as they liked the self-pace through the course and they stated that flipped classroom gave them more class time to practice English. The results presented here may facilitate improvements in the implementation of flipped classroom in EFL class. Furthermore, suggestions for further research are also presented

Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog.

Pluripotent stem cells (PSCs) hold significant promise in regenerative medicine due to their unlimited capacity for self-renewal and potential to differentiate into every cell type in the body. One major barrier to the use of PSCs is their potential risk for tumor initiation following differentiation and transplantation in vivo. In the current study we sought to evaluate the role of the tumor suppressor Pten in murine PSC neoplastic progression. Using eight functional assays that have previously been used to indicate PSC adaptation or transformation, Pten null embryonic stem cells (ESCs) failed to rate as significant in five of them. Instead, our data demonstrate that the loss of Pten causes the emergence of a small number of aggressive, teratoma-initiating embryonic carcinoma cells (ECCs) during differentiation in vitro, while the remaining 90-95% of differentiated cells are non-tumorigenic. Furthermore, our data show that the mechanism by which Pten null ECCs emerge in vitro and cause tumors in vivo is through increased survival and self-renewal, due to failed repression of the transcription factor Nanog

Dual gene activation and knockout screen reveals directional dependencies in genetic networks.

Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcus aureus to carry out a dual screen in which one gene is activated while a second gene is deleted in the same cell. We analyze the quantitative effects of activation and knockout to calculate genetic interaction and directionality scores for each gene pair. Based on the results from over 100,000 perturbed gene pairs, we reconstruct a directional dependency network for human K562 leukemia cells and demonstrate how our approach allows the determination of directionality in activating genetic interactions. Our interaction network connects previously uncharacterized genes to well-studied pathways and identifies targets relevant for therapeutic intervention

From Petrov-Einstein to Navier-Stokes in Spatially Curved Spacetime

We generalize the framework in arXiv:1104.5502 to the case that an embedding may have a nonvanishing intrinsic curvature. Directly employing the Brown-York stress tensor as the fundamental variables, we study the effect of finite perturbations of the extrinsic curvature while keeping the intrinsic metric fixed. We show that imposing a Petrov type I condition on the hypersurface geometry may reduce to the incompressible Navier-Stokes equation for a fluid moving in spatially curved spacetime in the near-horizon limit.Comment: 17 pages, references added, generalizing the metric form in part 3, version published in JHE

Estimating ecological carrying capacity for stock enhancement in marine ranching ecosystems of Northern China

Marine ranching has been proposed as a promising solution to manage the depleted coastal fishery ecosystem in recent decades across China. Marine ranching integrates the practices of artificial habitat-based with aquaculture-based enhancement. Assessing the ecological carrying capacity of target species for enhancement is a precondition for determining the optimal numbers for release, particularly for those species whose habitat restrictions have been eliminated through the construction of artificial habitats in the marine ranch. A responsible approach to stock enhancement aims not only to increase total yield and stock abundance but also to consider any potential effects on ecosystem structure and function. A time-dynamic, ecosystem model was constructed using Ecopath with Ecosim for the Laizhou Bay (Bohai Sea) marine ranching ecosystem in the nearshore waters of northern China. Two sedentary target species with potential for stock enhancement, i.e., the carnivorous red snail Rapana venosa and the detritivorous sea cucumber Apostichopus japonicus, were selected to simulate and estimate their ecological carrying capacities and project their overall effects on the ecosystem. Ecological carrying capacity was defined as the maximum standing stocks of the target species that would not cause “unacceptable” impacts on the ecosystem function and resilience, i.e., not cause any other group’s biomass to fall below 10% of its original biomass. The ecological carrying capacities estimated for R. venosa and A. japonicus were 623.46 and 200.57 t·km−2, respectively, corresponding to 7.8 and 5.0 times higher than their current standing stocks. Simulations of R. venosa enhancement showed distinct effects of increased target species abundance on other functional groups and ecosystem properties. An increase in red snail biomass caused negative impacts on the biomass of most other functional groups and ecosystem indicators, such as Finn’s cycling index, transfer efficiency, and Kempton’s Q index. In contrast, the simulated A. japonicus enhancement had relatively few impacts, and the biomasses of most other functional groups and ecosystem indicators did not change or changed very slightly (<5%). The current model framework provides a means of estimating the ecological carrying capacity in commercial-scale stock enhancement practices and avoiding potential ecological risks for marine ranching in northern China

Fluid/gravity duality with Petrov-like boundary condition in a spacetime with a cosmological constant

Recently it has been shown that imposing Petrov type I condition on the boundary may reduce the Einstein's equation to the Navier-Stokes equation in the non-relativistic and near-horizon limit. In this paper we extend this framework to a spacetime with a cosmological constant. By explicit construction we show that the Navier-Stokes equation can be derived from both black brane background and spatially curved spacetime. We also conjecture that imposing Petrov type I condition on the boundary should be equivalent to the conventional method using the hydrodynamical expansion of the metric in the near horizon limit.Comment: 14 pages; Version published in PR

High sensitivity micro-fiber Mach-Zehnder interferometric temperature sensors with a high index ring layer

The influence of the high index ring layer (HIRL) in a tapered fiber Mach-Zehnder interferometer (MZI) on the interference observed, and thus on its potential applications in temperature sensing, has been investigated. The MZI was comprised of a tapered Ring Core Fiber (RCF), spliced between two single mode fibers (SMF). Since part of core mode from the SMF was converted into cladding modes in the RCF, due to the mismatch in the cores between the RCF and SMF, the residual power enters and then propagates along the center of the RCF (silica). The difference in phase between the radiation travelling along these different paths is separated by the HIRL to generate an interference effect. Compared with fiber interferometers based on core and cladding mode interference, the thin fiber HIRL is capable of separating the high order cladding modes and the silica core mode, under grazing incident conditions. Therefore, the optical path difference (OPD) and the sensitivity are both substantially improved over what is seen in conventional devices, showing their potential for interferometric temperature sensor applications. The optimum temperature sensitivity obtained was 186.6 pm/°C, which is ∼ 11.7 times higher than has been reported previously