Analysis of dynamic stability for wind turbine blade under fluid-structure interaction

Aiming at improving vibration performance of 1.5 MW wind turbine blades, the theoretical model and the calculation process of vibration problems under geometric nonlinearity and unidirectional fluid-structure interaction (UFSI) were presented. The dynamic stability analysis on a 1.5 MW wind turbine blade was carried out. Both the maximum brandish displacement and the maximum Mises stress increase nonlinearly with the increase of wind speed. The influences of turbulent effect, wind shear effect and their joint effect on displacement and stress increase sequentially. Furthermore, the stability critical curves are calculated and analyzed. As a result, the stability region is established where the wind turbine blade can run safely

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models.

Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota, namely dysbiosis, is known to cause MetS and NAFLD. It is also known that systemic inflammation blocks insulin signaling pathways, leading to insulin resistance and glucose intolerance, which are the driving force for hepatic steatosis. Vitamin D receptor (VDR) is highly expressed in the ileum of the small intestine, which prompted us to test a hypothesis that vitamin D signaling may determine the enterotype of gut microbiota through regulating the intestinal interface. Here, we demonstrate that high-fat-diet feeding (HFD) is necessary but not sufficient, while additional vitamin D deficiency (VDD) as a second hit is needed, to induce robust insulin resistance and fatty liver. Under the two hits (HFD+VDD), the Paneth cell-specific alpha-defensins including α-defensin 5 (DEFA5), MMP7 which activates the pro-defensins, as well as tight junction genes, and MUC2 are all suppressed in the ileum, resulting in mucosal collapse, increased gut permeability, dysbiosis, endotoxemia, systemic inflammation which underlie insulin resistance and hepatic steatosis. Moreover, under the vitamin D deficient high fat feeding (HFD+VDD), Helicobacter hepaticus, a known murine hepatic-pathogen, is substantially amplified in the ileum, while Akkermansia muciniphila, a beneficial symbiotic, is diminished. Likewise, the VD receptor (VDR) knockout mice exhibit similar phenotypes, showing down regulation of alpha-defensins and MMP7 in the ileum, increased Helicobacter hepaticus and suppressed Akkermansia muciniphila. Remarkably, oral administration of DEFA5 restored eubiosys, showing suppression of Helicobacter hepaticus and increase of Akkermansia muciniphila in association with resolving metabolic disorders and fatty liver in the HFD+VDD mice. An in vitro analysis showed that DEFA5 peptide could directly suppress Helicobacter hepaticus. Thus, the results of this study reveal critical roles of a vitamin D/VDR axis in optimal expression of defensins and tight junction genes in support of intestinal integrity and eubiosis to suppress NAFLD and metabolic disorders

Analysis of dynamic stability for wind turbine blade under fluid-structure interaction

Aiming at improving vibration performance of 1.5 MW wind turbine blades, the theoretical model and the calculation process of vibration problems under geometric nonlinearity and unidirectional fluid-structure interaction (UFSI) were presented. The dynamic stability analysis on a 1.5 MW wind turbine blade was carried out. Both the maximum brandish displacement and the maximum Mises stress increase nonlinearly with the increase of wind speed. The influences of turbulent effect, wind shear effect and their joint effect on displacement and stress increase sequentially. Furthermore, the stability critical curves are calculated and analyzed. As a result, the stability region is established where the wind turbine blade can run safely

Analysis of dynamic stability for wind turbine blade under fluid-structure interaction

Aiming at improving vibration performance of 1.5 MW wind turbine blades, the theoretical model and the calculation process of vibration problems under geometric nonlinearity and unidirectional fluid-structure interaction (UFSI) were presented. The dynamic stability analysis on a 1.5 MW wind turbine blade was carried out. Both the maximum brandish displacement and the maximum Mises stress increase nonlinearly with the increase of wind speed. The influences of turbulent effect, wind shear effect and their joint effect on displacement and stress increase sequentially. Furthermore, the stability critical curves are calculated and analyzed. As a result, the stability region is established where the wind turbine blade can run safely

Influences of physical and structural parameters on vibration modes for large-scale rotating wind turbine blades

For large-scale offshore wind turbine blades, ANSYS and UG were respectively used to complete the solid modeling and the calculation of vibration modes, and the influences of the rotating speed on each order vibration mode and their main reasons were analyzed. Furthermore, the effects of material categories, the deviations of physical parameters in the process of material manufacture and structural parameters on the natural frequencies of rotating blades were respectively compared. Numerical results show that the dynamic stiffening effect of rotating blades is obvious, and the stress stiffness and the geometric stiffness play a dominant role on the natural frequencies from the first to the sixth order and from the seventh to the tenth order respectively. The influences of material categories on natural frequencies of the blades are significantly higher than those of physical parameter deviations and chord length changes. The effects of the equal amplitude increase of elasticity modulus or the chord length and the equal amplitude decrease of density on the tenth order frequency for the torsional vibration are less than those of them on the first nine orders' frequencies for the shimmy and flapping vibration, making that the increase amplitude of the blade natural frequencies first increases and then decreases with the increase of the order number. In addition, the results in this work can provide technical references for the optimization design and the further analysis of vibration characteristics of wind turbine blades

Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia.

A pandemic of metabolic diseases, consisting of type 2 diabetes, nonalcoholic fatty liver disease, and obesity, has imposed critical challenges for societies worldwide, prompting investigation of underlying mechanisms and exploration of low-cost and effective treatment. In this report, we demonstrate that metabolic disorders in mice generated by feeding with a high-fat diet without dietary vitamin D can be prevented by oral administration of polycationic amine resin. Oral administration of cholestyramine, but not the control uncharged polystyrene, was able to sequester negatively charged bacterial endotoxin in the gut, leading to 1) reduced plasma endotoxin levels, 2) resolved systemic inflammation and hepatic steatohepatitis, and 3) improved insulin sensitivity. Gut dysbiosis, characterized as an increase of the phylum Firmicutes and a decrease of Bacteroidetes and Akkermansia muciniphila, was fully corrected by cholestyramine, indicating that the negatively charged components in the gut are critical for the dysbiosis. Furthermore, fecal bacteria transplant, derived from cholestyramine-treated animals, was sufficient to antagonize the metabolic disorders of the recipient mice. These results indicate that the negatively charged components produced by dysbiosis are critical for biogenesis of metabolic disorders and also show a potential application of cationic polystyrene to treat metabolic disorders through promoting gut eubiosis

Variations in species diversity patterns and community assembly rules among vegetation types in the karst landscape

The various vegetation types in the karst landscape have been considered the results of heterogeneous habitats. However, the lack of a comprehensive understanding of regional biodiversity patterns and the underlying ecological processes limits further research on ecological management. This study established forest dynamic plots (FDPs) of the dominant vegetation types (shrubland, SL; mixed tree and shrub forest, MTSF; coniferous forest, CF; coniferous broadleaf mixed forest, CBMF; and broadleaf forest, BF) in the karst landscape and quantified the species diversity patterns and potential ecological processes. The results showed that in terms of diversity patterns, the evenness and species richness of the CF community were significantly lower than other vegetation types, while the BF community had the highest species richness. The other three vegetation types showed no significant variation in species richness and evenness. However, when controlling the number of individuals of FDPs, the rarefied species richness showed significant differences and ranked as BF > SL > MTSF > CBMF > CF, highlighting the importance of considering the impacts of abundance. Additionally, the community assembly of climax communities (CF or BF) was dominated by stochastic processes such as species dispersal or species formation, whereas deterministic processes (habitat filtering) dominated the secondary forests (SL, MTSF, and CBMF). These findings proved that community assembly differs mainly between the climax community and other communities. Hence, it is crucial to consider the biodiversity and of the potential underlying ecological processes together when studying regional ecology and management, particularly in heterogeneous ecosystems

Citrinin Derivatives From Penicillium Citrinum Y34 That Inhibit α-Glucosidase and ATP-Citrate Lyase

Two new citrinin dimers bearing a 6,6-spiroketal moiety (1 and 2) and four known analogues (3–6), together with 18 known citrinin monomers (7–24), were isolated from the culture of hydrothermal vent-associated fungus Penicillium citrinum Y34. Their structures were identified by extensive spectroscopic analyses, 13C NMR calculation in combination with DP4+, linear correlation coefficient (R2), and mean absolute error (MAE) values analyses, and electronic circular dichroism (ECD) calculation. The α-glucosidase and ATP-citrate lyase (ACL) inhibitory activities of isolated compounds were evaluated. Compounds 1, 3, and 12 displayed moderate α-glucosidase inhibitory activities with IC50 values of 239.8, 176.2, and 424.4 μM, respectively. Enzyme kinetics investigations of 1 and 3 suggested their non-competitive inhibition of α-glucosidase with Ki values of 204.3 and 212.7 μM, respectively. Meanwhile, compound 4 showed significant ACL inhibitory potential with an IC50 value of 17.4 μM. Furthermore, the interactions of 1, 3, and 12 with α-glucosidase and 4 with ACL were investigated by molecular docking assay. This study demonstrates that citrinins, especially for their dimers, could be potential lead compounds for the development of new agents for the treatment of metabolic diseases

Sequential Bayesian Decoding with a Population of Neurons

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