SO(3) Gauge model for neutrino masses and oscillations

I mainly describe neutrino masses and oscillations in the gauge model with $SO(3)_{F}$ lepton flavor symmetry and with two Higgs triplets. It is shown how the maximal mixing between $\nu_{\mu}$ and $\nu_{\tau}$ neutrinos comes out naturally after spontaneous breaking of the symmetry. The nearly two-flavor mixing scenario is resulted naturally from an approximate permutation symmetry between the two Higgs triplets. The hierarchy between the neutrino mass-squared differences, which is needed for reconciling both solar and atmospheric neutrino data, leads to an almost maximal mixing between $\nu_{e}$ and $\nu_{\mu}$ neutrinos. Thus the model favors the intriguing bi-maximal mixing scenario.The three Majorana neutrino masses are allowed to be nearly degenerate and large enough to play a significant cosmological role. The model can also lead to interesting phenomena on lepton-flavor violations via the $SO(3)_{F}$ gauge interactions.Comment: latex, no figures, invited talk at the Sixth Topical Seminar on Neutrino and Astroparticle Physics, San Miniato, Italy, May 1999, to appear in Nucl. Phys. B (Proc. Suppl.

Spontaneous Breaking of Flavor Symmetry and Naturalness of Nearly Degenerate Neutrino Masses and Bi-maximal Mixing

The gauge model with $SO(3)_{F}$ flavor symmetry and three Higgs triplets is studied. We show how the intriguing nearly degenerate neutrino mass and bi-maximal mixing scenario comes out naturally after spontaneous breaking of the symmetry. The hierarchy between the neutrino mass-squared differences, which is needed for reconciling both solar and atmospheric neutrino data, is naturally resulted from an approximate permutation symmetry. The model can also lead to interesting phenomena on lepton-flavor violations via the $SO(3)_{F}$ gauge interactions.Comment: 13 pages, latex, no figures, the version appearing in SCIENCE IN CHINA (Series A), Vol.35 No.9 (2000

B --> rho l nu Decay and |V_{ub}|

B --> rho l nu decay is analyzed in the effective theory of heavy quark with infinite mass limit. The matrix element relevant to the heavy to light vector meson semileptonic decays is parametrized by a set of four heavy flavor-spin independent universal wave functions at the leading order of effective theory. The form factors are calculated at the leading 1/m_Q order using the light cone sum rule method in the framework of effective theory. |V_{ub}| is then extracted via B --> rho l nu decay mode.Comment: 10 pages, ReVtex, 2 figures, corrected signs in some formula

Expression of anion exchanger 2 in human gastric cancer

Anion exchanger 2 (AE2), which mediates exchange of Cl-/HCO3- across the plasma membrane, is widely expressed in body tissues. It is most abundantly expressed in stomach and is responsible for the uptake of Cl- ions that are destined to become HCl molecules. Aim: To determine whether AE2 expression was altered in gastric tumors. Methods: We have studied AE2 expression in normal human gastric tissues (n =16) and in gastric tumors (n = 33) using immunohistochemistry and immunofluorescent labeling. Results: In normal gastric tissue positive staining was observed in gastric fundus gland, suggesting parietal cell-related expression of AE2, and AE2 expression was localized in the nuclear membrane and even in cell nuclei. For assay of cancerous gastric tissues, specimens of human gastric cancer arising from the region of the fundus (2 cases), the body (14 cases) and the antrum (17 cases) were randomly selected. Immunohistochemical staining has showed that AE2 was down-regulated in all 14 cancerous gastric body specimens, whereas staining for AE2 in cancerous antrum was less intense and had a diffuse profile. Conclusions: The data suggest that AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients.Анионный обменник 2 (АЕ2), который опосредует перенос Cl- /HCO3 - через плазматическую мембрану, экспрессируется клетками разных тканей. Самый высокий уровень экспрессии АЕ2 в желудке, поскольку этот белок отвечает за поглощение ионов Cl- , которые впоследствии используются для секреции HCl. Цель: Изучить изменения в экспрессии АЕ2 при раке желудка. Методы: исследована экспрессия АЕ2 в нормальных тканях (n = 16) и опухолях желудка (n = 33) с применением методов иммуногистохимии и иммунофлуоресценции. Результаты: в нетрансформированной ткани желудка в фундальной железе выявляли сильную положительную реакцию, что свидетельствует об экспрессии АЕ2 париетальными клетками, причем экспрессия АЕ2 была локализирована в ядерной мембране и в ядре. В опухолях желудка (фундального отдела (n = 2), тела (n = 14) и антрального отдела (n = 17)), отобранных случайным образом, был проведен анализ экспрессии АЕ2. Иммуногистохимическое исследование показало снижение экспрессии АЕ2 во всех 14 случаях рака тела желудка. Окрашивание АЕ2 в образцах рака антрального отдела желудка было менее интенсивным и диффузным. Выводы: полученные данные позволяют предположить наличие связи между экспрессией АЕ2 и развитием рака желудка, а также ахлоргидрией, отмечаемой у больных раком желудка

Magnetic phase diagram in Eu1−x_{1-x}Lax_xFe2_2As2_2 single crystals

We have systematically measured resistivity, susceptibility and specific heat under different magnetic fields (H) in Eu$_{1-x}$La$_x$Fe$_2$As$_2$ single crystals. It is found that a metamagnetic transition from A-type antiferromagnetism to ferromagnetism occurs at a critical field for magnetic sublattice of $Eu^{2+}$. The jump of specific heat is suppressed and shifts to low temperature with increasing H up to the critical value, then shifts to high temperature with further increasing H. Such behavior supports the metamagnetic transition. Detailed H-T phase diagrams for x=0 and 0.15 crystals are given, and possible magnetic structure is proposed. Magnetoresistance measurements indicate that there exists a strong coupling between local moment of $Eu^{2+}$ and charge in Fe-As layer. These results are very significant to understand the underlying physics of FeAs superconductors.Comment: 5 pages, 4 figure

Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: a review of preclinical and clinical studies

The mesenchymal-epithelial transition (MET) receptor tyrosine kinase binds the hepatocyte growth factor to activate downstream cell signaling pathways involved in cell proliferation, survival, and migration. Several genetic mechanisms can result in an aberrant activation of this receptor in cancer cells. One such activating mechanism involves the acquisition of gene mutations that cause MET exon 14 skipping (METex14) during mRNA splicing. Mutations leading to METex14 are found in approximately 3?4% of patients with non-small cell lung cancer (NSCLC). Accumulating evidence suggests that METex14 is a true, independent oncogenic driver in NSCLC, as well as being an independent prognostic factor for poorer survival in patients with NSCLC. The successes of target therapies have relied on improved understanding of the genetic alterations that lead to the dysregulation of the molecular pathways and more advanced molecular diagnostics. Multiple efforts have been made to target the MET pathway in cancer; however, real clinical progress has only occurred since the emergence of METex14 as a valid biomarker for MET inhibition. Capmatinib is a highly potent and selective type Ib inhibitor of MET. Following preclinical demonstration of activity against MET-dependent cancer cell line growth and METdriven tumor growth in xenograft models, data from a phase 1 clinical trial showed an acceptable safety profile of capmatinib and preliminary evidence of efficacy in patients with MET-dysregulated NSCLC. The multicohort GEOMETRY mono-1 phase 2 trial reported objective response rates of 68% and 41% in treatment-na?ve and in pre-treated patients with METex14 advanced NSCLC, respectively. These results have supported the approval of capmatinib by the US Food and Drug Administration for patients with metastatic NSCLC harboring METex14.Pathogenesis and treatment of chronic pulmonary disease

Charmless Bs→PP,PV,VVB_s\to PP, PV, VV Decays Based on the six-quark Effective Hamiltonian with Strong Phase Effects II

We provide a systematic study of charmless $B_s \to PP, PV, VV$ decays ($P$ and $V$ denote pseudoscalar and vector mesons, respectively) based on an approximate six-quark operator effective Hamiltonian from QCD. The calculation of the relevant hard-scattering kernels is carried out, the resulting transition form factors are consistent with the results of QCD sum rule calculations. By taking into account important classes of power corrections involving "chirally-enhanced" terms and the vertex corrections as well as weak annihilation contributions with non-trivial strong phase, we present predictions for the branching ratios and CP asymmetries of $B_s$ decays into PP, PV and VV final states, and also for the corresponding polarization observables in VV final states. It is found that the weak annihilation contributions with non-trivial strong phase have remarkable effects on the observables in the color-suppressed and penguin-dominated decay modes. In addition, we discuss the SU(3) flavor symmetry and show that the symmetry relations are generally respected