The philosopher as artist: Ludwig Wittgenstein seen through Edoardo Paolozzi

In this article I argue that the strong fascination that Wittgenstein has had for artists cannot be explained primarily by the content of his work, and in particular not by his sporadic observation on aesthetics, but rather by stylistic features of his work formal aspects of his writing. Edoardo Paolozzi’s testimony shows that artists often had a feeling of acquaintance or familiarity with the philosopher, which I think is due to stylistic features of his work, such as the colloquial tone in which Wittgenstein shares his observation with the reader, but also the lack of long-winded arguments or explanations. In the concluding part I suggest that we can read Wittgenstein’s artworks of a specific kind: as philosophical works of art

SINO-FOREST CORPORATION: THE CASE OF THE STANDING TIMBER

The Sino-Forest Case provides a real-world example of financial misstatement and audit failure.2 The case encompasses related parties, auditing procedures for tangible assets, and internal controls. Sino-Forest Corporation was engaged primarily in the purchase and sale of standing timber in the People’s Republic of China (PRC). The principal executive office was in Hong Kong and its securities were traded on the Toronto Stock Exchange until 2011. The management of Sino-Forest created a complex web of subsidiaries and related entities whereby it controlled the purchase and sale of standing timber in widely dispersed regions of the PRC. Sino-Forest personnel created false documents related to these transactions, which were materially misstated in the company’s financial statements. Sino-Forest auditors failed to properly recognize and deal with these misstatements, despite concerns expressed by members of the audit team about a lack of evidence regarding the standing timber assets. As a result of these problems, the company was delisted from the Toronto Stock Exchange and is now defunct

Development of an Early Identification and Response Model of Malpractice Prevention

The dramatic rise in the incidence of malpractice claims over the past thirty years has revealed several problems with the U.S. system of medical dispute resolution. First, the sudden and unexpected increase in claims has created an insurance crisis wherein various medical specialists have had difficulty obtaining affordable insurance coverage. One such crisis occurred in Florida in the mid-1980\u27s, when an inability of many physicians to procure medical malpractice coverage caused some to limit or curtail their practice. This resulted in access problems for the public. This phenomenon has disproportionately befallen physicians practicing obstetric medicine. Second, besides contributing to periodic crises of access, the current medical dispute resolution system is often responsible for long delays in resolving claims and in compensating victims. Third, compensation is sometimes inequitable, encouraging frivolous suits and making the system expensive to operate. Finally, while there is no evidence that the system reduces bad care, it clearly contributes to increased cost by encouraging unjustified defensive medicine

Chronicles of Oklahoma

Necrology section from Volume 30, Number 2, Summer 1952. It includes documents honoring the lives of Paul Nesbitt, Mrs. Jasper Sipes, Marion Riley Tittle, and Clinton Riley Strong

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109905/1/cptclpt19923.pd

Meniscal transplantation and its effect on osteoarthritis risk : an abridged protocol for the MeTEOR study : a comprehensive cohortstudy incorporating a pilot randomised controlled trial

Objectives: Subtotal or total meniscectomy in the medial or lateral compartment of the knee results in a high risk of future osteoarthritis. Meniscal allograft transplantation has been performed for over thirty years with the scientifically plausible hypothesis that it functions in a similar way to a native meniscus. It is thought that a meniscal allograft transplant has a chondroprotective effect, reducing symptoms and the long-term risk of osteoarthritis. However, this hypothesis has never been tested in a high-quality study on human participants. This study aims to address this shortfall by performing a pilot randomised controlled trial within the context of a comprehensive cohort study design. Methods: Patients will be randomised to receive either meniscal transplant or a non-operative, personalised knee therapy program. MRIs will be performed every four months for one year. The primary endpoint is the mean change in cartilage volume in the weight-bearing area of the knee at one year post intervention. Secondary outcome measures include the mean change in cartilage thickness, T2 maps, patient-reported outcome measures, health economics assessment and complications. Results: This study is expected to report its findings in 2016

Approximate Thumbnail Preserving Encryption

Thumbnail preserving encryption (TPE) was suggested by Wright et al. as a way to balance privacy and usability for online image sharing. The idea is to encrypt a plaintext image into a ciphertext image that has roughly the same thumbnail as well as retaining the original image format. At the same time, TPE allows users to take advantage of much of the functionality of online photo management tools, while still providing some level of privacy against the service provider. In this work we present three new approximate TPE encryption schemes. In our schemes, ciphertexts and plaintexts have perceptually similar, but not identical, thumbnails. Our constructions are the first TPE schemes designed to work well with JPEG compression. In addition, we show that they also have provable security guarantees that characterize precisely what information about the plaintext is leaked by the ciphertext image. We empirically evaluate our schemes according to the similarity of plaintext and ciphertext thumbnails, increase in file size under JPEG compression, preservation of perceptual image hashes, among other aspects. We also show how approximate TPE can be an effective tool to thwart inference attacks by machine-learning image classifiers, which have shown to be effective against other image obfuscation techniques

Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities

Objective: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population. Methods: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights–Inwood Columbia Aging Project. Multiple linear modeling with PLINK was performed to examine the additive genetic effects on ln(WMHV) after controlling for age, sex, total intracranial volume, and principal components of ancestry. Gene-based tests of association were performed using VEGAS. Replication was performed in independent samples of Europeans, African Americans, and Asians. Results: From the SNP analysis, a total of 17 independent SNPs in 7 genes had suggestive evidence of association with WMHV in Hispanics (p < 1 × 10−5) and 5 genes from the gene-based analysis with p < 1 × 10−3. One SNP (rs9957475 in GATA6) and 1 gene (UBE2C) demonstrated evidence of association (p < 0.05) in the African American sample. Four SNPs with p < 1 × 10−5 were shown to affect binding of SPI1 using RegulomeDB. Conclusions: This GWAS of 2 community-based Hispanic cohorts revealed several novel WMH-associated genetic variants. Further replication is needed in independent Hispanic samples to validate these suggestive associations, and fine mapping is needed to pinpoint causal variants

Measurement of one-particle correlations and momentum distributions for trapped 1D gases

van Hove's theory of scattering of probe particles by a macroscopic target is generalized so as to relate the differential cross section for atomic ejection via stimulated Raman transitions to one-particle momentum-time correlations and momentum distributions of 1D trapped gases. This method is well suited to probing the longitudinal momentum distributions of 1D gases in situ, and examples are given for bosonic and fermionic atoms.Comment: 4 pages, 2 .eps figure

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial advantages over currently available treatments. The therapeutic strategy employs a single recombinant ‘targeting agent’ that binds a toxin at two unique sites and a ‘clearing Ab’ that binds two epitopes present on each targeting agent. Co-administration of the targeting agent and the clearing Ab results in decoration of the toxin with up to four Abs to promote accelerated clearance. The therapeutic strategy was applied to two Botulinum neurotoxin (BoNT) serotypes and protected mice from lethality in two different intoxication models with an efficacy equivalent to conventional antitoxin serum. Targeting agents were a single recombinant protein consisting of a heterodimer of two camelid anti-BoNT heavy-chain-only Ab VH (VHH) binding domains and two E-tag epitopes. The clearing mAb was an anti-E-tag mAb. By comparing the in vivo efficacy of treatments that employed neutralizing vs. non-neutralizing agents or the presence vs. absence of clearing Ab permitted unprecedented insight into the roles of toxin neutralization and clearance in antitoxin efficacy. Surprisingly, when a post-intoxication treatment model was used, a toxin-neutralizing heterodimer agent fully protected mice from intoxication even in the absence of clearing Ab. Thus a single, easy-to-produce recombinant protein was as efficacious as polyclonal antiserum in a clinically-relevant mouse model of botulism. This strategy should have widespread application in antitoxin development and other therapies in which neutralization and/or accelerated clearance of a serum biomolecule can offer therapeutic benefit