Retrospective Analysis of Clinical and Cost Outcomes Associated with Methicillin-Resistant Staphylococcus aureus Complicated Skin and Skin Structure Infections Treated with Daptomycin, Vancomycin, or Linezolid

Objective. The objective of this analysis was to compare clinical and cost outcomes associated with patients who had suspected or documented methicillin-resistant Staphylococcus aureus (MRSA) infections treated with daptomycin, vancomycin, or linezolid in complicated skin and skin structure infections (cSSSIs). Design. This was a retrospective analysis conducted from February to June of 2007. Appropriate data was collected, collated, and subsequently evaluated with the purpose of quantifying length of stay, antibiotic therapy duration, clinical cure rates, adverse drug events, and cost of hospitalization. Results. All 82 patients included in the analysis experienced clinical cure. The duration of antibiotic therapy was similar among the three groups yet the length of hospitalization was slightly shorter in the daptomycin group. Conclusions. The incidence of resistant staphylococcal infections is increasing; therefore, judicious use of MRSA active agents is paramount. Future studies are necessary to determine if MRSA treatment options can be stratified based on the severity of the infectious process

Evaluating the impact of a longitudinal patient case on the development of professionalism and professional identity

This article explores the student outcomes of a progressive case on the development of professional identity and professionalism within first-year student pharmacists

Nonequilibrium dynamics of vortex arrest in a finite-temperature Bose-Einstein condensate

We perform finite-temperature dynamical simulations of the arrest of a rotating Bose-Einstein condensate by a fixed trap anisotropy, using a Hamiltonian classical-field method. We consider a quasi-two-dimensional condensate containing a single vortex in equilibrium with a rotating thermal cloud. Introducing an elliptical deformation of the trapping potential leads to the loss of angular momentum from the system. We identify the condensate and the complementary thermal component of the nonequilibrium field, and compare the evolution of their angular momenta and angular velocities. By varying the trap anisotropy we alter the relative efficiencies of the vortex-cloud and cloud-trap coupling. For strong trap anisotropies the angular momentum of the thermal cloud may be entirely depleted before the vortex begins to decay. For weak trap anisotropies, the thermal cloud exhibits a long-lived steady state in which it rotates at an intermediate angular velocity.Comment: 10 pages, 6 figures. v2: Minor changes in response to referee's comments. To appear in PR

Quantum state of two trapped Bose-Einstein condensates with a Josephson coupling

We consider the precise quantum state of two trapped, coupled Bose Einstein condensates in the two-mode approximation. We seek a representation of the state in terms of a Wigner-like distribution on the two-mode Bloch sphere. The problem is solved using a self-consistent rotation of the unknown state to the south pole of the sphere. The two-mode Hamiltonian is projected onto the harmonic oscillator phase plane, where it can be solved by standard techniques. Our results show how the number of atoms in each trap and the squeezing in the number difference depend on the physical parameters. Considering negative scattering lengths, we show that there is a regime of squeezing in the relative phase of the condensates which occurs for weaker interactions than the superposition states found by Cirac et al% (quant-ph/9706034, 13 June 1997). The phase squeezing is also apparent in mildly asymmetric trap configurations.Comment: 26 pages, 11 figure

Characteristics of Two-Dimensional Quantum Turbulence in a Compressible Superfluid

Under suitable forcing a fluid exhibits turbulence, with characteristics strongly affected by the fluid's confining geometry. Here we study two-dimensional quantum turbulence in a highly oblate Bose-Einstein condensate in an annular trap. As a compressible quantum fluid, this system affords a rich phenomenology, allowing coupling between vortex and acoustic energy. Small-scale stirring generates an experimentally observed disordered vortex distribution that evolves into large-scale flow in the form of a persistent current. Numerical simulation of the experiment reveals additional characteristics of two-dimensional quantum turbulence: spontaneous clustering of same-circulation vortices, and an incompressible energy spectrum with $k^{-5/3}$ dependence for low wavenumbers $k$ and $k^{-3}$ dependence for high $k$.Comment: 7 pages, 7 figures. Reference [29] updated for v

Energies and collapse times of symmetric and symmetry-breaking states of finite systems with a U(1) symmetry

We study quantum systems of volume V, which will exhibit the breaking of a U(1) symmetry in the limit of V \to \infty, when V is large but finite. We estimate the energy difference between the `symmetric ground state' (SGS), which is the lowest-energy state that does not breaks the symmetry, and a `pure phase vacuum' (PPV), which approaches a symmetry-breaking vacuum as V \to \infty. Under some natural postulates on the energy of the SGS, it is shown that PPVs always have a higher energy than the SGS, and we derive a lower bound of the excess energy. We argue that the lower bound is O(V^0), which becomes much larger than the excitation energies of low-lying excited states for a large V. We also discuss the collapse time of PPVs for interacting many bosons. It is shown that the wave function collapses in a microscopic time scale, because PPVs are not energy eigenstates. We show, however, that for PPVs the expectation value of any observable, which is a finite polynomial of boson operators and their derivatives, does not collapse for a macroscopic time scale. In this sense, the collapse time of PPVs is macroscopically long.Comment: In the revised manuscript, Eq. (22), Ref. [8], and Notes [13], [15] and [17] have been adde

C-Field Methods for Non-Equilibrium Bose Gases

We review c-field methods for simulating the non-equilibrium dynamics of degenerate Bose gases beyond the mean-field Gross-Pitaevskii approximation. We describe three separate approaches that utilise similar numerical methods, but have distinct regimes of validity. Systems at finite temperature can be treated with either the closed-system projected Gross-Pitaevskii equation (PGPE), or the open-system stochastic projected Gross-Pitaevskii equation (SPGPE). These are both applicable in quantum degenerate regimes in which thermal fluctuations are significant. At low or zero temperature, the truncated Wigner projected Gross-Pitaevskii equation (TWPGPE) allows for the simulation of systems in which spontaneous collision processes seeded by quantum fluctuations are important. We describe the regimes of validity of each of these methods, and discuss their relationships to one another, and to other simulation techniques for the dynamics of Bose gases. The utility of the SPGPE formalism in modelling non-equilibrium Bose gases is illustrated by its application to the dynamics of spontaneous vortex formation in the growth of a Bose-Einstein condensate.Comment: 7 pages, 1 figure. Unedited version of chapter to appear in Quantum Gases: Finite Temperature and Non-Equilibrium Dynamics (Vol. 1 Cold Atoms Series). N.P. Proukakis, S.A. Gardiner, M.J. Davis and M.H. Szymanska, eds. Imperial College Press, London (in press). See http://www.icpress.co.uk/physics/p817.html v2: Added arXiv cross-reference

Quantum Dynamics of Three Coupled Atomic Bose-Einstein Condensates

The simplest model of three coupled Bose-Einstein Condensates (BEC) is investigated using a group theoretical method. The stationary solutions are determined using the SU(3) group under the mean field approximation. This semiclassical analysis using the system symmetries shows a transition in the dynamics of the system from self trapping to delocalization at a critical value for the coupling between the condensates. The global dynamics are investigated by examination of the stable points and our analysis shows the structure of the stable points depends on the ratio of the condensate coupling to the particle-particle interaction, undergoes bifurcations as this ratio is varied. This semiclassical model is compared to a full quantum treatment, which also displays the dynamical transition. The quantum case has collapse and revival sequences superposed on the semiclassical dynamics reflecting the underlying discreteness of the spectrum. Non-zero circular current states are also demonstrated as one of the higher dimensional effects displayed in this system.Comment: Accepted to PR

Microbial dynamics in a High Arctic glacier forefield: A combined field, laboratory, and modelling approach

Modelling the development of soils in glacier forefields is necessary in order to assess how microbial and geochemical processes interact and shape soil development in response to glacier retreat. Furthermore, such models can help us predict microbial growth and the fate of Arctic soils in an increasingly ice-free future. Here, for the first time, we combined field sampling with laboratory analyses and numerical modelling to investigate microbial community dynamics in oligotrophic proglacial soils in Svalbard. We measured low bacterial growth rates and growth efficiencies (relative to estimates from Alpine glacier forefields) and high sensitivity of bacterial growth rates to soil temperature (relative to temperate soils). We used these laboratory measurements to inform parameter values in a new numerical model and significantly refined predictions of microbial and biogeochemical dynamics of soil development over a period of roughly 120 years. The model predicted the observed accumulation of autotrophic and heterotrophic biomass. Genomic data indicated that initial microbial communities were dominated by bacteria derived from the glacial environment, whereas older soils hosted a mixed community of autotrophic and heterotrophic bacteria. This finding was simulated by the numerical model, which showed that active microbial communities play key roles in fixing and recycling carbon and nutrients. We also demonstrated the role of allochthonous carbon and microbial necromass in sustaining a pool of organic material, despite high heterotrophic activity in older soils. This combined field, laboratory, and modelling approach demonstrates the value of integrated model-data studies to understand and quantify the functioning of the microbial community in an emerging High Arctic soil ecosystem

Measurements of Relative Phase in Binary Mixtures of Bose-Einstein Condensates

We have measured the relative phase of two Bose-Einstein condensates (BEC) using a time-domain separated-oscillatory-field condensate interferometer. A single two-photon coupling pulse prepares the double condensate system with a well-defined relative phase; at a later time, a second pulse reads out the phase difference accumulated between the two condensates. We find that the accumulated phase difference reproduces from realization to realization of the experiment, even after the individual components have spatially separated and their relative center-of-mass motion has damped.Comment: 12 pages, 3 figure