C.L. Wrenn Letter

Letter replying to Dr. Robert Boyer on his questions about the poet Auden. Wrenn had been Auden\u27s tutor in his last year as an undergraduate at the Christ Church at Oxford. Source: Oxford Universityhttps://digitalcommons.snc.edu/audencorrespondence/1020/thumbnail.jp

BUY LOCAL BRANDS RISING: THE SECRET INGREDIENT TO SUSTAINING AN ENDURING CLEVELAND BAKERY’S LEGACY

This creative project explores the subject of brand sustainability for local businesses. Evaluating bodies of literature in place branding and brand management, the project aims to investigate the trendy philosophy known as buy local, how small businesses can harness the power of their local community to both develop and sustain the company’s brand. With success from buy local campaigns, small businesses in return strengthen the community’s economy and the city’s brand. This essay uses Davis Bakery and Delicatessen, a 76-year-old Cleveland business, as a case study to illustrate the creation and maintenance of a buy local brand. The case study was developed from the perspective of an agency evaluating and developing a client’s brand strategy through competitive and market analyses, and the development of a creative brief and brand guidelines

Examining the sources of occupational stress in an emergency department

Background Previous work has established that health care staff, in particular emergency department (ED) personnel, experience significant occupational stress but the underlying stressors have not been well quantified. Such data inform interventions that can reduce cases of occupational mental illness, burnout, staff turnover and early retirement associated with cumulative stress. Aims To develop, implement and evaluate a questionnaire examining the origins of occupational stress in the ED. Methods A questionnaire co-designed by an occupational health practitioner and ED management administered to nursing, medical and support staff in the ED of a large English teaching hospital in 2015. The questionnaire assessed participants’ demographic characteristics and perceptions of stress across three dimensions (demand–control–support, effort–reward and organizational justice). Work-related stressors in ED staff were compared with those of an unmatched control group from the acute ear, nose and throat (ENT) and neurology directorate. Results A total of 104 (59%) ED staff returned questionnaires compared to 72 staff (67%) from the acute ENT/neurology directorate. The ED respondents indicated lower levels of job autonomy, management support and involvement in organizational change, but not work demand. High levels of effort–reward imbalance and organizational injustice were reported by both groups. Conclusions Our findings suggest that internal ED interventions to improve workers’ job control, increase support from management and involvement in organizational change may reduce work stress. The high levels of effort–reward imbalance and organizational injustice reported by both groups may indicate that wider interventions beyond the ED are also needed to address these issues

Normative Alethic Pluralism

Some philosophers have argued that truth is a norm of judgement and have provided a variety of formulations of this general thesis. In this paper, I shall side with these philosophers and assume that truth is a norm of judgement. What I am primarily interested in here are two core questions concerning the judgement-truth norm: (i) what are the normative relationships between truth and judgement? And (ii) do these relationships vary or are they constant? I argue for a pluralist picture—what I call Normative Alethic Pluralism (NAP)—according to which (i) there is more than one correct judgement-truth norm and (ii) the normative relationships between truth and judgement vary in relation to the subject matter of the judgement. By means of a comparative analysis of disagreement in three areas of the evaluative domain—refined aesthetics, basic taste and morality—I show that there is an important variability in the normative significance of disagreement—I call this the variability conjecture. By presenting a variation of Lynch’s scope problem for alethic monism, I argue that a monistic approach to the normative function of truth is unable to vindicate the conjecture. I then argue that normative alethic pluralism provides us with a promising model to account for it

Highly Parallel Translation of DNA Sequences into Small Molecules

A large body of in vitro evolution work establishes the utility of biopolymer libraries comprising 1010 to 1015 distinct molecules for the discovery of nanomolar-affinity ligands to proteins.[1], [2], [3], [4], [5] Small-molecule libraries of comparable complexity will likely provide nanomolar-affinity small-molecule ligands.[6], [7] Unlike biopolymers, small molecules can offer the advantages of cell permeability, low immunogenicity, metabolic stability, rapid diffusion and inexpensive mass production. It is thought that such desirable in vivo behavior is correlated with the physical properties of small molecules, specifically a limited number of hydrogen bond donors and acceptors, a defined range of hydrophobicity, and most importantly, molecular weights less than 500 Daltons.[8] Creating a collection of 1010 to 1015 small molecules that meet these criteria requires the use of hundreds to thousands of diversity elements per step in a combinatorial synthesis of three to five steps. With this goal in mind, we have reported a set of mesofluidic devices that enable DNA-programmed combinatorial chemistry in a highly parallel 384-well plate format. Here, we demonstrate that these devices can translate DNA genes encoding 384 diversity elements per coding position into corresponding small-molecule gene products. This robust and efficient procedure yields small molecule-DNA conjugates suitable for in vitro evolution experiments

Lightweight composite fighting cover prototype development program

The U.S. Army Field Assistance Science and Technology Program requested Oak Ridge National Laboratory (ORNL) to demonstrate the use of lightweight composite materials in construction of overhead covers for reinforced infantry fighting positions. In recent years, ORNL researchers have designed and tested several concepts for lightweight ballistic protection structures, and they have developed numerous prototype composite structures for military and civilian applications. In the current program, composite panel designs and materials are tested and optimized to meet anticipated static and dynamic load conditions for the overhead cover structure. Ten prototype composite covers were built at ORNL for use in Army field tests. Each composite cover has a nominal surface area of 12 ft[sup 2] and a nominal weight of 8 lb. Four of the prototypes are made with folding sections to improve their handling characteristics. The composite covers exhibit equivalent performance in Army field tests to covers made with conventional materials that weigh four times as much

Mechanisms of breast cancer metastasis

Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development of therapies that focus on mechanisms of metastasis and might even allow us to avoid toxic therapies that are currently used for this disease. For example, if we had a drug that targeted a gene that is critical for metastasis, we might even be able to cure a vast majority of patients with breast cancer. By bringing together scientists with expertise in molecular aspects of breast cancer metastasis, and those with expertise in the mechanical aspects of metastasis, this paper probes interesting aspects of the metastasis cascade, further enlightening us in our efforts to improve the outcome from breast cancer treatments

Photoelectron Flux Build-Up in the Plasmasphere

Processes which confine photoelectrons to the plasmasphere (e.g., collisional backscattering from the thermosphere and magnetic trapping due to pitch angle redistribution through Coulomb collisions in the plasmasphere) tend to increase the steady state photoelectron flux in the plasmasphere above the amplitude level that would otherwise have been attained. Theoretical calculations are presented of steady state photoelectron fluxes in the plasmasphere, for specified atmospheric and ionospheric conditions. (Observational plasma line intensity data for these conditions exist and will be compared elsewhere.) General features of the angular distribution are presented and compared with observations. The transparency of the plasmasphere and the backscattering properties of the thermosphere are investigated. The buildup effect due to collisional backscatter alone is calculated, and the combined buildup effect of pitch angle diffusion and backscatter is estimated. It is found that the inclusion of these effects increases the steady state photoelectron flux amplitude in the plasmasphere by about 50% over the value obtained when the buildup effects are neglected. The calculated steady state photoelectron fluxes in the plasmasphere are in good agreement with the available observations

Extreme energetic electron fluxes in low Earth orbit: Analysis of POES E > 30, E > 100 and E > 300 keV electrons

Energetic electrons are an important space weather hazard. Electrons with energies less than about 100 keV cause surface charging while higher energy electrons can penetrate materials and cause internal charging. In this study we conduct an extreme value analysis of the maximum 3-hourly flux of E> 30 keV, E> 100 keV and E> 300 keV electrons in low Earth orbit as a function of L∗, for geomagnetic field lines that map to the outer radiation belt, using data from the National Oceanic and Atmospheric Administration (NOAA) Polar Operational Environmental Satellites (POES) from July 1998 to June 2014. The 1 in 10 year flux of E> 30 keV electrons shows a general increasing trend with distance ranging from 1.8×107 cm−2s−1sr−1 at L∗ = 3.0 to 6.6×107 cm−2s−1sr−1 at L∗ = 8.0. The 1 in 10 year flux of E> 100 keV electrons peaks at L∗= 4.5 - 5.0 at 1.9×107 cm−2s−1sr−1 decreasing to minima of 7.1×106 and 8.7×106 cm−2s−1sr−1 at L∗ = 3.0 and 8.0 respectively. In contrast to the E> 30 keV electrons, the 1 in 10 year flux of E> 300 keV electrons shows a general decreasing trend with distance, ranging from 2.4×106 cm−2s−1sr−1 at L∗ = 3.0 to 1.2×105 cm−2s−1sr−1 at L∗= 8.0. Our analysis suggests that there is a limit to the E> 30 keV electrons with an upper bound in the range 5.1×107- 8.8×107 cm−2s−1sr−1. However, the results suggest that there is no upper bound for the E> 100 keV and E> 300 keV electrons