483 research outputs found

    All I Do is Win : The No-Lose Strategy of CAFO Regulation Under the CAA

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    Corporate farms, often known as concentrated animial feeding operations ( CAFO\u27), provide inexpensive animal products but do so by externalizing the cost of their operation in the form of environmental harms and risks to human health. This article explores one possible approach to mitigating CAFO-caused harms. It argues that CAFO regulation under any one of three Clean Air Act ( CAA ) programs will result in net benefits, not just for air quality, but also for other CAFO-caused harms and thus, that CAA regulation of CAFOs is a no-lose strategy. The article then goes further to conclude that, while regulation under any one of these programs would cause industry to internalize some of the costs of its operations, regulation under § 111 of the CAA most fully accomplishes this and will therefore result in the best overall outcomes for human health and the environment

    Use of an interactive website to improve communication and education at an academic hospitalist program

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    Statement of Problem: The academic hospitalist section at UNM expanded by nearly 50% over just 12 months and was intimately involved with major changes in the residency ward structure. Section members repeatedly cited the need for improved communication about administrative and educational matters. Innovation Objectives: To provide a readily available interactive website for use by our hospitalist section to communicate about administrative and educational matters. Program Description: We established an interactive website for use by our hospitalist section through a commercial internet service. Section members were invited to register, and were allowed to contribute comments, edit existing pages, add pages, upload files, and provide links to other websites. Viewing rights to the website were unrestricted. The initial website was begun with 6 pages. Findings to Date: In the first month, 16/17 of our hospitalists and 2/3 of our mid-level providers registered and subsequently make contributions to the website. In the first 90 days, 85 new pages were created and 132 files were uploaded to create a website of 120 MB. Of the first 91 pages, 47 dealt with administrative issues (such as schedules, committee meetings, minutes, credentialing, billing and coding); 27 involved specific information about the residency and new ward structure; 14 specifically addressed educational topics; and 4 addressed faculty development and research efforts. At the end of one year, 289 pages and 330 files were added, creating a website of 627 MB. Lectures by hospitalist are now recorded and uploaded to the site. The website is now frequently viewed by residents and medical students who cite the value of the educational pages and pages that deal with residency issues. 80% of surveyed hospitalists found the site to be helpful or very helpful. To date the size of the website has not exceeded the initial free service, and the Section has incurred no direct cost related to this project. Key Lessons Learned: Establishment of an interactive website resulted in contributions by almost all hospitalists in our Section, has improved communication, and proved to be of value to medical students and residents with regard to educatio

    In search of late-stage planetary building blocks

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    Genetic contributions to the final stages of planetary growth, including materials associated with the giant Moon forming impact, late accretion, and late heavy bombardment are examined using siderophile elements. Isotopic similarities between the Earth and Moon for both lithophile and siderophile elements collectively lead to the suggestion that the genetics of the building blocks for Earth, and the impactor involved in the Moon-forming event were broadly similar, and shared some strong genetic affinities with enstatite chondrites. The bulk genetic fingerprint of materials subsequently added to Earth by late accretion, defined as the addition of ~0.5 wt.% of Earth's mass to the mantle, following cessation of core formation, was characterized by 187Os/188Os and Pd/Ir ratios that were also similar to those in some enstatite chondrites. However, the integrated fingerprint of late accreted matter differs from enstatite chondrites in terms of the relative abundances of certain other HSE, most notably Ru/Ir. The final ≤0.05 wt.% addition of material to the Earth and Moon, believed by some to be part of a late heavy bombardment, included a component with much more fractionated relative HSE abundances than evidenced in the average late accretionary component. Heterogeneous 182W/184Wisotopic compositions of some ancient terrestrial rocks suggest that some very early formed mantle domains remained chemically distinct for long periods of time following primary planetary accretion. This evidence for sluggish mixing of the early mantle suggests that if late accretionary contributions to the mantle were genetically diverse, it may be possible to isotopically identify the disparate primordial components in the terrestrial rock record using the siderophile element tracers Ru and Mo.NASA grants NNX13AF83G and NNA14AB07A NSF-CSEDI grants EAR1160728 and EAR1265169

    Malignant and Nonmalignant Gene Signatures in Squamous Head and Neck Cancer

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    Genetic events specific to the pathogenesis of malignancy can offer clues to the tumorigenesis process. The objective of this study was to identify gene alterations that differentiate tumor and nontumor lesions in squamous head and neck cancer (HNSCC). DNA from 220 primary HNSCC with concurrently present tumor and nontumor lesions from the same patient was interrogated for genomic alterations of loss or gain of copy. Conditional logistic regression dealt with tumor and non-tumor records within a patient. Of 113 genes, 53 had univariate effects (P < 0.01), of which 16 genes remained in the multivariable model with P < 0.01. The model had a C-index (ROC) of 0.93. Loss of CDKN2B and gain of BCL6, FGF3, and PTP4A3 predicted tumor. Loss of BAK1 and CCND1 and gain of STCH predicted nontumor. This highly powered model assigned alterations in 16 genes specific for malignant versus nonmalignant lesions, supporting their contribution to the pathogenesis of HNSCC as well as their potential utility as relevant targets for further evaluation as markers of early detection and progression

    SUMMARY REPORT OF THERMIONIC CONVERTER IN-PILE EXPERIMENTS

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    Nucleosynthetic molybdenum isotope anomalies in iron meteorites – new evidence for thermal processing of solar nebula material

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    publisher: Elsevier articletitle: Nucleosynthetic molybdenum isotope anomalies in iron meteorites – new evidence for thermal processing of solar nebula material journaltitle: Earth and Planetary Science Letters articlelink: https://doi.org/10.1016/j.epsl.2017.05.001 content_type: article copyright: © 2017 The Authors. Published by Elsevier B.V.© 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). https://doi.org/10.1016/j.epsl.2017.05.001

    Phylogenetically independent behavior mediating geographic distributions suggests habitat is a strong driver of phenotype in crangonyctid amphipods

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    It is unclear if geographic distributions of animals are behaviorally mediated or simply maintained by ecologically-driven deleterious effects on fitness. Furthermore, it is not well known how behaviors that may affect geographic distributions and responses to environmental stressors evolve. To explore this, we examined behavioral and physiological reactions to light in six species of amphipods in the family Crangonyctidae collected from a variety of subterranean and epigean habitats. Stark differences between epigean and subterranean habitats occupied by different crangonyctid species allowed this clade to serve as an appropriate model system for studying the link between habitat and phenotype. We sampled habitats in or adjacent to the Edwards Aquifer in central Texas and collected two epigean and four stygobiontic species. We examined respiratory and behavioral responses to light in all study species. We found that similarities in behavioral and physiological responses to light between species were only weakly correlated with genetic relatedness but were correlated with habitat type. However, the breadth of variation in phenotype was found to be correlated with phylogenetic relationships, suggesting that population level trait evolution likely involves interactions between standing population level variation and strength of selection. Our findings suggest that natural selection via environmental conditions may outweigh history of common ancestry when predicting phenotypic similarities among species, and that behavioral and physiological phenotypes may mediate the evolution of biogeographic distributions
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