Letter from J[oseph] Worcester to John Muir, [1893] Feb 18.

[4]points that she must make clear, but they much and [illegible]tty fear that Mrs Butler’s repressed manner will chill rather than warm her [illegible]. [Do?] it is your [own way?], with the [illegible] the [seeds?], anything in your hand, and [illegible] from twenty to thirty [minutes?]. Excuse, and [believe me?]Yours sincerelyJoe Worcester[1]1030 Valley st. S.F.Feb. 18thDear Mr [Muir?],I understand that [Mrs Butler?] has written to you, making a request of you. I do not know what she said in her letter, but I have a [illegible] fear that she does not make it clear how important to us all her [illegible]ing is, and how much she needs help. She has charge of the [illegible] of the California flora,09916 [2]and she has done much and excellent work not only in drawing the flowers in their habitat, but in [gathering?] the plants and seeds with the purpose of making a [field?] of flowers around the California Building. She cannot carry out the well-derived plan for this without help, and she has found it very difficult to [interest?] the [illegible] in it, so she has appealed to some of the ladies of the Century Club.[3]They will do what they can, and have set apart an afternoon in which Mrs Butler’s drawings will be shown and her plan unfolded, but they much need help in the way of informal talk from one having knowledge and enthusiasm in the matter of our wild-flowers, and no one has these as you have. [Miss Hamlin?] and [Mrs Jarboc?] will support her in drawing from h[illegible] th

Crossing Cultures: Guides and Models for Development, Selection, and Application

Despite many calls for it, there has been little action toward an all-inclusive manuscript that is practical, empirically verified, and provides guidelines for becoming and remaining strategically culturally adaptive. Further, a tremendous number of current articles and books emphasize managing or leading in an era of globalization. To meet these calls to work, learn, and innovate across cultures, the goal must be to move from the mass of unrelated assertions to the weaving of co-created, manageable models that are useful in learning, teaching, and practice

AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences

An elastic neutron scattering instrument, the advanced neutron diffractometer/reflectometer (AND/R), has recently been commissioned at the National Institute of Standards and Technology Center for Neutron Research. The AND/R is the centerpiece of the Cold Neutrons for Biology and Technology partnership, which is dedicated to the structural characterization of thin films and multilayers of biological interest. The instrument is capable of measuring both specular and nonspecular reflectivity, as well as crystalline or semicrystalline diffraction at wave-vector transfers up to approximately 2.20 Å(-1). A detailed description of this flexible instrument and its performance characteristics in various operating modes are given.D. J. M. is supported through a NSF NIRT grant Contract No. 0304062

A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

Kidney stone disease causes significant morbidity and increases health care utilization. In this work, we decipher the cellular and molecular niche of the human renal papilla in patients with calcium oxalate (CaOx) stone disease and healthy subjects. In addition to identifying cell types important in papillary physiology, we characterize collecting duct cell subtypes and an undifferentiated epithelial cell type that was more prevalent in stone patients. Despite the focal nature of mineral deposition in nephrolithiasis, we uncover a global injury signature characterized by immune activation, oxidative stress and extracellular matrix remodeling. We also identify the association of MMP7 and MMP9 expression with stone disease and mineral deposition, respectively. MMP7 and MMP9 are significantly increased in the urine of patients with CaOx stone disease, and their levels correlate with disease activity. Our results define the spatial molecular landscape and specific pathways contributing to stone-mediated injury in the human papilla and identify associated urinary biomarkers

The detector system of the Daya Bay reactor neutrino experiment

postprin

Letter from J[oseph] Worcester to John Muir, [1893] Feb 18.

[4]points that she must make clear, but they much and [illegible]tty fear that Mrs Butler’s repressed manner will chill rather than warm her [illegible]. [Do?] it is your [own way?], with the [illegible] the [seeds?], anything in your hand, and [illegible] from twenty to thirty [minutes?]. Excuse, and [believe me?]Yours sincerelyJoe Worcester[1]1030 Valley st. S.F.Feb. 18thDear Mr [Muir?],I understand that [Mrs Butler?] has written to you, making a request of you. I do not know what she said in her letter, but I have a [illegible] fear that she does not make it clear how important to us all her [illegible]ing is, and how much she needs help. She has charge of the [illegible] of the California flora,09916 [2]and she has done much and excellent work not only in drawing the flowers in their habitat, but in [gathering?] the plants and seeds with the purpose of making a [field?] of flowers around the California Building. She cannot carry out the well-derived plan for this without help, and she has found it very difficult to [interest?] the [illegible] in it, so she has appealed to some of the ladies of the Century Club.[3]They will do what they can, and have set apart an afternoon in which Mrs Butler’s drawings will be shown and her plan unfolded, but they much need help in the way of informal talk from one having knowledge and enthusiasm in the matter of our wild-flowers, and no one has these as you have. [Miss Hamlin?] and [Mrs Jarboc?] will support her in drawing from h[illegible] th