1,421 research outputs found

    Effective Techniques of Supervision for Instruction in Vocational Agriculture

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    In the preliminary statements of the introduction, an attempt was made to establish the importance of farming as an occupation and to justify research in all of its many areas. Since the passage of the Smith-Hughes act in 1917, teachers of Vocational Agriculture have employed a variety of techniques in developing and supervising farming programs with all-day students on the home farm. The study has been conducted in order to isolate the techniques contributing most to the success of farming programs. The use of some of these practices which are rated high, in this study, should result in teachers of vocational agriculture doing a more effective job of supervising the farming programs of their all-day students. This study is primarily concerned with the effective techniques for supervision of farming programs of all-day boys on the home farm. This study deals with information compiled from data supplied by a representative group of vocational agriculture teachers in Area I, Area II, and Area III. In making this study, the writer does not wish to point out the weaknesses of any particular program or teacher, but rather to make possible an overview of the factors which have in the past contributed to the development of supervised farming programs. No attempt was made to determine the causes of the conditions found

    Mining the TRAF6/p62 interactome for a selective ubiquitination motif

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    A new approach is described here to predict ubiquitinated substrates of the E3 ubiquitin ligase, TRAF6, which takes into account its interaction with the scaffold protein SQSTM1/p62. A novel TRAF6 ubiquitination motif defined as [–(hydrophobic)–k–(hydrophobic)–x–x–(hydrophobic)– (polar)–(hydrophobic)–(polar)–(hydrophobic)] was identified and used to screen the TRAF6/p62 interactome composed of 155 proteins, that were either TRAF6 or p62 interactors, or a negative dataset, composed of 54 proteins with no known association to either TRAF6 or p62. NRIF (K19), TrkA (K485), TrkB (K811), TrkC (K602 and K815), NTRK2 (K828), NTRK3 (K829) and MBP (K169) were found to possess a perfect match for the amino acid consensus motif for TRAF6/p62 ubiquitination. Subsequent analyses revealed that this motif was biased to the C-terminal regions of the protein (nearly 50% the sites), and had preference for loops (~50%) and helices (~37%) over beta-strands (15% or less). In addition, the motif was observed to be in regions that were highly solvent accessible (nearly 90%). Our findings suggest that specific Lysines may be selected for ubiquitination based upon an embedded code defined by a specific amino acid motif with structural determinants. Collectively, our results reveal an unappreciated role for the scaffold protein in targeting ubiquitination. The findings described herein could be used to aid in identification of other E3/scaffold ubiquitination sites

    A study of the structure of jet turbulence producing jet noise

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    Characteristics of turbulent structure of mixing region near outlet of circular subsonic jet and production of jet nois

    Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52

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    <div><p>Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to <i>manganism</i>. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide <sup>52</sup>Mn (<i>t</i><sub><i>1/2</i></sub> = 5.6 d) by proton bombardment (<i>E</i><sub><i>p</i></sub><15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography. An aqueous solution of [<sup>52</sup>Mn]MnCl<sub>2</sub> was nebulized into a closed chamber with openings through which mice inhaled the aerosol, and a separate cohort of mice received intravenous (IV) injections of [<sup>52</sup>Mn]MnCl<sub>2</sub>. <i>Ex vivo</i> biodistribution was performed at 1 h and 1 d post-injection/inhalation (p.i.). In both trials, we observed uptake in lungs and thyroid at 1 d p.i. Manganese is known to cross the blood-brain barrier, as confirmed in our studies following IV injection (0.86%ID/g, 1 d p.i.) and following inhalation of aerosol, (0.31%ID/g, 1 d p.i.). Uptake in salivary gland and pancreas were observed at 1 d p.i. (0.5 and 0.8%ID/g), but to a much greater degree from IV injection (6.8 and 10%ID/g). In a separate study, mice received IV injection of an imaging dose of [<sup>52</sup>Mn]MnCl<sub>2</sub>, followed by <i>in vivo</i> imaging by positron emission tomography (PET) and <i>ex vivo</i> biodistribution. The results from this study supported many of the results from the biodistribution-only studies. In this work, we have confirmed results in the literature and contributed new results for the biodistribution of inhaled radiomanganese for several organs. Our results could serve as supporting information for environmental and occupational regulations, for designing PET studies utilizing <sup>52</sup>Mn, and/or for predicting the biodistribution of manganese-based MR contrast agents.</p></div

    Sound attenuation in a condensing vapor

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    The process of acoustic attenuation in a condensing medium is investigated using a continuumlike formulation that allows for the phase-exchange process. The liquid phase is assumed sufficiently disperse so that the field may be treated as a continuum. The elementary relaxation processes associated with droplet velocity, temperature, and vapor pressure equilibration are equally important in determining the attenuation when vapor, liquid, and inert gas mass fractions are of the same order. When the liquid mass fraction is small, however, a strong attenuation band appears at low frequencies. This attenuation process involves a coupled relaxation process in which heat transfer and vaporization processes combine to change the temperature of the relatively large gas mass. This attenuation band (i) centers on a frequency that is proportional to the concentration of liquid, and (ii) has a maximum value that varies directly as the concentration of condensible vapor and roughly as the square of the latent heat of vaporization. When the concentrations of liquid and condensible vapor are both small, the low-frequency attenuation band is nearly isolated and may be described in a convenient analytical manner

    Tasty Cookies, Inc.: A Master Budget Case

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    You are the owner of your own cookie company.&nbsp; Fast growth and the need to expand have made it necessary for you to seek financing from a local bank.&nbsp; However, you need to show the banker your plans for the coming year.&nbsp; Using your own, unique data, you will prepare a comprehensive budget and proforma financial statements to show the banker your projected earnings and financial position.&nbsp; Good luck getting that bank loan

    The Student-Athlete Life/Career Portfolio: A Multifaceted Approach to Life and Career Development

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    The student-athlete life/career portfolio is a process that developed reflective practice and allowed for an in-depth portrayal of the experiences of each person as an individual and an athlete. The contents of the life/career portfolio provided a unique document that is far more illustrative of an individual's abilities and achievement sthan the traditional resume

    Infrared phonon dynamics of multiferroic BiFeO3 single crystal

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    We discuss the first infrared reflectivity measurement on a BiFeO3 single crystal between 5 K and room temperature. The 9 predicted ab-plane E phonon modes are fully and unambiguously determined. The frequencies of the 4 A1 c-axis phonons are found. These results settle issues between theory and data on ceramics. Our findings show that the softening of the lowest frequency E mode is responsible for the temperature dependence of the dielectric constant, indicating that the ferroelectric transition in BiFeO3 is soft-mode driven.Comment: 5 pages (figures included

    Neutral carbon in the Egg Nebula (AFGL 2688)

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    A search for sub-mm C I emission from seven stars that are surrounded by dense molecular gas shells led to the detection, in the case of the "Egg Nebula' (AFGL 2688), of an 0.9 K line implying a C I/CO value greater than 5. The material surrounding this star must be extremely carbon-rich, and it is suggested that the apparently greater extent of the C I emission region may be due to the effects of the galactic UV field on the shell's chemistry, as suggested by Huggins and Glassgold (1982)
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