60 research outputs found
Wide-field CCD imaging at CFHT: the MOCAM example
We describe a new 4096x4096 pixel CCD mosaic camera (MOCAM) available at the
prime focus of the Canada-France-Hawaii Telescope (CFHT). The camera is a
mosaic of four 2048x2048\mu$m
pixels, providing a field of view of 14'x14' at a scale of 0.21''/pixel. MOCAM
is equipped with B, V, R and I filters and has demonstrated image quality of
0.5''-0.6'' FWHM over the entire field. MOCAM will also be used with the CFHT
adaptive optic bonnette and will provide a field of view of 90'' at a scale of
0.02 ''/pixel. MOCAM works within the CFHT Pegasus software environment and
observers familiar with this system require no additional training to use this
camera effectively. The technical details, the performance and the first images
obtained on the telescope with MOCAM are presented. In particular, we discuss
some important improvements with respect to the standard single-CCD FOCAM
camera, such as multi-output parallel readout and dynamic anti-blooming. We
also discuss critical technical issues concerning future wide-field imaging
facilities at the CFHT prime focus in light of our experience with MOCAM and
our recent experience with the even larger UH 8192x8192 pixel CCD mosaic
camera.Comment: Accepted for publication in Publication of the Astronomical Society
of the Pacific. Latex with aas2pp4.sty and epsf.sty. 12 pages, 10 figure
HARP/ACSIS: A submillimetre spectral imaging system on the James Clerk Maxwell Telescope
This paper describes a new Heterodyne Array Receiver Programme (HARP) and
Auto-Correlation Spectral Imaging System (ACSIS) that have recently been
installed and commissioned on the James Clerk Maxwell Telescope (JCMT). The
16-element focal-plane array receiver, operating in the submillimetre from 325
to 375 GHz, offers high (three-dimensional) mapping speeds, along with
significant improvements over single-detector counterparts in calibration and
image quality. Receiver temperatures are 120 K across the whole band and
system temperatures of 300K are reached routinely under good weather
conditions. The system includes a single-sideband filter so these are SSB
figures. Used in conjunction with ACSIS, the system can produce large-scale
maps rapidly, in one or more frequency settings, at high spatial and spectral
resolution. Fully-sampled maps of size 1 square degree can be observed in under
1 hour.
The scientific need for array receivers arises from the requirement for
programmes to study samples of objects of statistically significant size, in
large-scale unbiased surveys of galactic and extra-galactic regions. Along with
morphological information, the new spectral imaging system can be used to study
the physical and chemical properties of regions of interest. Its
three-dimensional imaging capabilities are critical for research into
turbulence and dynamics. In addition, HARP/ACSIS will provide highly
complementary science programmes to wide-field continuum studies, and produce
the essential preparatory work for submillimetre interferometers such as the
SMA and ALMA.Comment: MNRAS Accepted 2009 July 2. 18 pages, 25 figures and 6 table
Symbolic computer language for multibody systems
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76245/1/AIAA-20770-590.pd
FLAMINGOS-2: The Facility Near-Infrared Wide-field Imager & Multi-Object Spectrograph for Gemini
We report on the design and status of the FLAMINGOS-2 instrument - a
fully-cryogenic facility near-infrared imager and multi-object spectrograph for
the Gemini 8-meter telescopes. FLAMINGOS-2 has a refractive all-spherical
optical system providing 0.18-arcsecond pixels and a 6.2-arcminute circular
field-of-view on a 2048x2048-pixel HAWAII-2 0.9-2.4 mm detector array. A
slit/decker wheel mechanism allows the selection of up to 9 multi-object
laser-machined plates or 3 long slits for spectroscopy over a 6x2-arcminute
field of view, and selectable grisms provide resolutions from 1300 to
3000 over the entire spectrograph bandpass. FLAMINGOS-2 is also
compatible with the Gemini Multi-Conjugate Adaptive Optics system, providing
multi-object spectroscopic capabilities over a 3x1-arcminute field with high
spatial resolution (0.09-arcsec/pixel). We review the designs of optical,
mechanical, electronics, software, and On-Instrument WaveFront Sensor
subsystems. We also present the current status of the project, currently in
final testing in mid-2006.Comment: Submitted to SPIE Astronomical Telescopes & Instrumentation; 12
pages, incl. color figure
The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) has evolved into a highly successful human pathogen. It deftly subverts the bactericidal mechanisms of alveolar macrophages, ultimately inducing granuloma formation and establishing long-term residence in the host. These hallmarks of Mtb infection are facilitated by the metabolic adaptation of the pathogen to its surrounding environment and the biosynthesis of molecules that mediate its interactions with host immune cells. The sulfate assimilation pathway of Mtb produces a number of sulfur-containing metabolites with important contributions to pathogenesis and survival. This pathway is regulated by diverse environmental cues and regulatory proteins that mediate sulfur transactions in the cell. Here, we discuss the transcriptional and biochemical mechanisms of sulfur metabolism regulation in Mtb and potential small molecule regulators of the sulfate assimilation pathway that are collectively poised to aid this intracellular pathogen in its expert manipulation of the host. From this global analysis, we have identified a subset of sulfur-metabolizing enzymes that are sensitive to multiple regulatory cues and may be strong candidates for therapeutic intervention
STEM education in the twenty-first century: learning at work-an exploration of design and technology teacher perceptions and practices
Teachers’ knowledge of STEM education, their understanding, and pedagogical application of that knowledge is intrinsically linked to the subsequent effectiveness of STEM delivery within their own practice; where a teacher’s knowledge and understanding is deficient, the potential for pupil learning is ineffective and limited. Set within the context of secondary age phase education in England and Wales (11–16 years old), this paper explores how teachers working within the field of design and technology education acquire new knowledge in STEM; how understanding is developed and subsequently embedded within their practice to support the creation of a diverse STEM-literate society. The purpose being to determine mechanisms by which knowledge acquisition occurs, to reconnoitre potential implications for education and learning at work, including consideration of the role which new technologies play in the development of STEM knowledge within and across contributory STEM subject disciplines. Underpinned by an interpretivist ontology, work presented here builds upon the premise that design and technology is an interdisciplinary educational construct and not viewed as being of equal status to other STEM disciplines including maths and science. Drawing upon the philosophical field of symbolic interactionism and constructivist grounded theory, work embraces an abductive methodology where participants are encouraged to relate design and technology within the context of STEM education. Emergent findings are discussed in relation to their potential to support teachers’ educational development for the advancement of STEM literacy, and help secure design and technology’s place as a subject of value within a twenty-first Century curriculum
Identification of gene targets against dormant phase Mycobacterium tuberculosis infections
<p>Abstract</p> <p>Background</p> <p><it>Mycobacterium tuberculosis</it>, the causative agent of tuberculosis (TB), infects approximately 2 billion people worldwide and is the leading cause of mortality due to infectious disease. Current TB therapy involves a regimen of four antibiotics taken over a six month period. Patient compliance, cost of drugs and increasing incidence of drug resistant <it>M. tuberculosis </it>strains have added urgency to the development of novel TB therapies. Eradication of TB is affected by the ability of the bacterium to survive up to decades in a dormant state primarily in hypoxic granulomas in the lung and to cause recurrent infections.</p> <p>Methods</p> <p>The availability of <it>M. tuberculosis </it>genome-wide DNA microarrays has lead to the publication of several gene expression studies under simulated dormancy conditions. However, no single model best replicates the conditions of human pathogenicity. In order to identify novel TB drug targets, we performed a meta-analysis of multiple published datasets from gene expression DNA microarray experiments that modeled infection leading to and including the dormant state, along with data from genome-wide insertional mutagenesis that examined gene essentiality.</p> <p>Results</p> <p>Based on the analysis of these data sets following normalization, several genome wide trends were identified and used to guide the selection of targets for therapeutic development. The trends included the significant up-regulation of genes controlled by <it>devR</it>, down-regulation of protein and ATP synthesis, and the adaptation of two-carbon metabolism to the hypoxic and nutrient limited environment of the granuloma. Promising targets for drug discovery were several regulatory elements (<it>devR/devS</it>, <it>relA</it>, <it>mprAB</it>), enzymes involved in redox balance and respiration, sulfur transport and fixation, pantothenate, isoprene, and NAD biosynthesis. The advantages and liabilities of each target are discussed in the context of enzymology, bacterial pathways, target tractability, and drug development.</p> <p>Conclusion</p> <p>Based on our bioinformatics analysis and additional discussion of in-depth biological rationale, several novel anti-TB targets have been proposed as potential opportunities to improve present therapeutic treatments for this disease.</p
Assertive Outreach: policy and reality
This paper presents research commissioned by the North East Assertive Outreach R&D Consortium. It comprised of an examination of the case-loads of all 29 mental health assertive outreach teams across the 12 trusts of the North East of England
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