Self-Healing Control with Multifunctional Gate Drive Circuits for Power Converters

Many commercial and military transport systems have fault diagnostic functions implemented to help protect the device when a severe fault occurs. However, most present systems do not contain prognostics capability which would allow operators to observe an unhealthy system component in its pre- fault condition. In industry applications, scheduled downtime can result in considerable cost avoidance. The next technology step is self-healing system components which observe not only potential problems, but can also take steps to continue operation under abnormal conditions - whether due to long-term normal wear-and-tear or sudden combat damage. In this paper, current and voltage information using the double-layer gate drive concept is fed to intelligent networks to identify the type of fault and its location. These intelligent networks are based on unsupervised and supervised learning networks (self-organizing maps and learning vector quantization networks respectively). The proposed concept allows the reconfiguration of the electric machinery system for continued normal operation of the machine. This paper presents an intelligent health monitoring and self-healing control strategy for a multi-phase multilevel motor drive under various types of faults

The Vehicle, Fall 1973

Table of Contents Just the SameRick Hoblerpage 4 Gentle NightPatricia Christpage 5 Baby Makes TwoMarilyn Beckerpage 5 StephenMarilyn Beckerpage 5 Seventh AlarumKeith Fuerstpage 6 DallasKeith Fuerstpage 6 An Old Floor CandlePeggy Wallacepage 7 Without LoveRod Boehmerpage 7 No TouchJerilyn Jonespage 8 A BeginningJerilyn Jonespage 8 First Frost of AutumnMelvin Zaloudekpage 9 TrisetrieWilliam Uteschpage 9 EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp

The Vehicle, Fall 1973

Table of Contents Just the SameRick Hoblerpage 4 Gentle NightPatricia Christpage 5 Baby Makes TwoMarilyn Beckerpage 5 StephenMarilyn Beckerpage 5 Seventh AlarumKeith Fuerstpage 6 DallasKeith Fuerstpage 6 An Old Floor CandlePeggy Wallacepage 7 Without LoveRod Boehmerpage 7 No TouchJerilyn Jonespage 8 A BeginningJerilyn Jonespage 8 First Frost of AutumnMelvin Zaloudekpage 9 TrisetrieWilliam Uteschpage 9 EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp

Assessing the cost of global biodiversity and conservation knowledge

Knowledge products comprise assessments of authoritative information supported by stan-dards, governance, quality control, data, tools, and capacity building mechanisms. Considerable resources are dedicated to developing and maintaining knowledge productsfor biodiversity conservation, and they are widely used to inform policy and advise decisionmakers and practitioners. However, the financial cost of delivering this information is largelyundocumented. We evaluated the costs and funding sources for developing and maintain-ing four global biodiversity and conservation knowledge products: The IUCN Red List ofThreatened Species, the IUCN Red List of Ecosystems, Protected Planet, and the WorldDatabase of Key Biodiversity Areas. These are secondary data sets, built on primary datacollected by extensive networks of expert contributors worldwide. We estimate that US$160million (range: US$116–204 million), plus 293 person-years of volunteer time (range: 278–308 person-years) valued at US$14 million (range US$12–16 million), were invested inthese four knowledge products between 1979 and 2013. More than half of this financingwas provided through philanthropy, and nearly three-quarters was spent on personnelcosts. The estimated annual cost of maintaining data and platforms for three of these knowl-edge products (excluding the IUCN Red List of Ecosystems for which annual costs were notpossible to estimate for 2013) is US$6.5 million in total (range: US$6.2–6.7 million). We esti-mated that an additional US$114 million will be needed to reach pre-defined baselines ofdata coverage for all the four knowledge products, and that once achieved, annual mainte-nance costs will be approximately US$12 million. These costs are much lower than those tomaintain many other, similarly important, global knowledge products. Ensuring that biodi-versity and conservation knowledge products are sufficiently up to date, comprehensiveand accurate is fundamental to inform decision-making for biodiversity conservation andsustainable development. Thus, the development and implementation of plans for sustain-able long-term financing for them is critical

Assessing the cost of global biodiversity and conservation knowledge

Knowledge products comprise assessments of authoritative information supported by standards, governance, quality control, data, tools, and capacity building mechanisms. Considerable resources are dedicated to developing and maintaining knowledge products for biodiversity conservation, and they are widely used to inform policy and advise decision makers and practitioners. However, the financial cost of delivering this information is largely undocumented. We evaluated the costs and funding sources for developing and maintaining four global biodiversity and conservation knowledge products: The IUCN Red List of Threatened Species, the IUCN Red List of Ecosystems, Protected Planet, and the World Database of Key Biodiversity Areas. These are secondary data sets, built on primary data collected by extensive networks of expert contributors worldwide. We estimate that US$160 million (range: US$116-204 million), plus 293 person-years of volunteer time (range: 278-308 person-years) valued at US$14 million (range US$12-16 million), were invested in these four knowledge products between 1979 and 2013. More than half of this financing was provided through philanthropy, and nearly three-quarters was spent on personnel costs. The estimated annual cost of maintaining data and platforms for three of these knowledge products (excluding the IUCN Red List of Ecosystems for which annual costs were not possible to estimate for 2013 ) is US$6.5 million in total (range: US$6.2-6.7 million). We estimated that an additional US$114 million will be needed to reach pre-defined baselines of data coverage for all the four knowledge products, and that once achieved, annual maintenance costs will be approximately US$12 million. These costs are much lower than those to maintain many other, similarly important, global knowledge products. Ensuring that biodiversity and conservation knowledge products are sufficiently up to date, comprehensive and accurate is fundamental to inform decision-making for biodiversity conservation and sustainable development. Thus, the development and implementation of plans for sustainable long-term financing for them is critical

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate isomerase (MPI), the first enzyme in the mannose metabolism pathway, as a sensitizer to both cytarabine and FLT3 inhibitors across multiple AML models. Mechanistically, we identify a connection between mannose metabolism and fatty acid metabolism, that is mediated via preferential activation of the ATF6 arm of the unfolded protein response (UPR). This in turn leads to cellular accumulation of polyunsaturated fatty acids, lipid peroxidation and ferroptotic cell death in AML cells. Our findings provide further support to the role of rewired metabolism in AML therapy resistance, unveil a connection between two apparently independent metabolic pathways and support further efforts to achieve eradication of therapy-resistant AML cells by sensitizing them to ferroptotic cell death