42 research outputs found
Self-Healing Control with Multifunctional Gate Drive Circuits for Power Converters
Many commercial and military transport systems have fault diagnostic functions implemented to help protect the device when a severe fault occurs. However, most present systems do not contain prognostics capability which would allow operators to observe an unhealthy system component in its pre- fault condition. In industry applications, scheduled downtime can result in considerable cost avoidance. The next technology step is self-healing system components which observe not only potential problems, but can also take steps to continue operation under abnormal conditions - whether due to long-term normal wear-and-tear or sudden combat damage. In this paper, current and voltage information using the double-layer gate drive concept is fed to intelligent networks to identify the type of fault and its location. These intelligent networks are based on unsupervised and supervised learning networks (self-organizing maps and learning vector quantization networks respectively). The proposed concept allows the reconfiguration of the electric machinery system for continued normal operation of the machine. This paper presents an intelligent health monitoring and self-healing control strategy for a multi-phase multilevel motor drive under various types of faults
The Vehicle, Fall 1973
Table of Contents
Just the SameRick Hoblerpage 4
Gentle NightPatricia Christpage 5
Baby Makes TwoMarilyn Beckerpage 5
StephenMarilyn Beckerpage 5
Seventh AlarumKeith Fuerstpage 6
DallasKeith Fuerstpage 6
An Old Floor CandlePeggy Wallacepage 7
Without LoveRod Boehmerpage 7
No TouchJerilyn Jonespage 8
A BeginningJerilyn Jonespage 8
First Frost of AutumnMelvin Zaloudekpage 9
TrisetrieWilliam Uteschpage 9
EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp
The Vehicle, Fall 1973
Table of Contents
Just the SameRick Hoblerpage 4
Gentle NightPatricia Christpage 5
Baby Makes TwoMarilyn Beckerpage 5
StephenMarilyn Beckerpage 5
Seventh AlarumKeith Fuerstpage 6
DallasKeith Fuerstpage 6
An Old Floor CandlePeggy Wallacepage 7
Without LoveRod Boehmerpage 7
No TouchJerilyn Jonespage 8
A BeginningJerilyn Jonespage 8
First Frost of AutumnMelvin Zaloudekpage 9
TrisetrieWilliam Uteschpage 9
EyesMarvinetta Woodleypage 9https://thekeep.eiu.edu/vehicle/1030/thumbnail.jp
Assessing the cost of global biodiversity and conservation knowledge
Knowledge products comprise assessments of authoritative information supported by stan-dards, governance, quality control, data, tools, and capacity building mechanisms. Considerable resources are dedicated to developing and maintaining knowledge productsfor biodiversity conservation, and they are widely used to inform policy and advise decisionmakers and practitioners. However, the financial cost of delivering this information is largelyundocumented. We evaluated the costs and funding sources for developing and maintain-ing four global biodiversity and conservation knowledge products: The IUCN Red List ofThreatened Species, the IUCN Red List of Ecosystems, Protected Planet, and the WorldDatabase of Key Biodiversity Areas. These are secondary data sets, built on primary datacollected by extensive networks of expert contributors worldwide. We estimate that US116–204 million), plus 293 person-years of volunteer time (range: 278–308 person-years) valued at US12–16 million), were invested inthese four knowledge products between 1979 and 2013. More than half of this financingwas provided through philanthropy, and nearly three-quarters was spent on personnelcosts. The estimated annual cost of maintaining data and platforms for three of these knowl-edge products (excluding the IUCN Red List of Ecosystems for which annual costs were notpossible to estimate for 2013) is US6.2–6.7 million). We esti-mated that an additional US12 million. These costs are much lower than those tomaintain many other, similarly important, global knowledge products. Ensuring that biodi-versity and conservation knowledge products are sufficiently up to date, comprehensiveand accurate is fundamental to inform decision-making for biodiversity conservation andsustainable development. Thus, the development and implementation of plans for sustain-able long-term financing for them is critical
Assessing the cost of global biodiversity and conservation knowledge
Knowledge products comprise assessments of authoritative information supported by
standards, governance, quality control, data, tools, and capacity building mechanisms.
Considerable resources are dedicated to developing and maintaining knowledge
products for biodiversity conservation, and they are widely used to inform policy and
advise decision makers and practitioners. However, the financial cost of delivering this
information is largely undocumented. We evaluated the costs and funding sources for
developing and maintaining four global biodiversity and conservation knowledge
products: The IUCN Red List of Threatened Species, the IUCN Red List of
Ecosystems, Protected Planet, and the World Database of Key Biodiversity Areas.
These are secondary data sets, built on primary data collected by extensive networks
of expert contributors worldwide. We estimate that US116-204
million), plus 293 person-years of volunteer time (range: 278-308 person-years) valued
at US12-16 million), were invested in these four knowledge
products between 1979 and 2013. More than half of this financing was provided
through philanthropy, and nearly three-quarters was spent on personnel costs. The
estimated annual cost of maintaining data and platforms for three of these knowledge
products (excluding the IUCN Red List of Ecosystems for which annual costs were not
possible to estimate for 2013 ) is US6.2-6.7 million).
We estimated that an additional US12 million. These costs
are much lower than those to maintain many other, similarly important, global
knowledge products. Ensuring that biodiversity and conservation knowledge products
are sufficiently up to date, comprehensive and accurate is fundamental to inform
decision-making for biodiversity conservation and sustainable development. Thus, the
development and implementation of plans for sustainable long-term financing for them
is critical
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate isomerase (MPI), the first enzyme in the mannose metabolism pathway, as a sensitizer to both cytarabine and FLT3 inhibitors across multiple AML models. Mechanistically, we identify a connection between mannose metabolism and fatty acid metabolism, that is mediated via preferential activation of the ATF6 arm of the unfolded protein response (UPR). This in turn leads to cellular accumulation of polyunsaturated fatty acids, lipid peroxidation and ferroptotic cell death in AML cells. Our findings provide further support to the role of rewired metabolism in AML therapy resistance, unveil a connection between two apparently independent metabolic pathways and support further efforts to achieve eradication of therapy-resistant AML cells by sensitizing them to ferroptotic cell death