38 research outputs found
Portfolio Diversification with Commodity Futures: Properties of Levered Futures
Portfolio Diversification with Commodity Futures: Properties of Levered Futures This study extends previous work on the impact of commodity futures on portfolio performance by explicitly incorporating levered futures into the portfolio optimization problem. Using data on nine individual commodity futures and one aggregate index from 1994-2003, we find that collateralized and levered futures strategies perform similarly in an ex-post context. Significant differences between the approaches emerge however when constraints on investment behavior exist. Further, levered futures do not result in a prohibitive number of margin calls. The investment performances of the collateralized and the levered strategies vary little across different rebalancing intervals, and frequent portfolio rebalancing does not necessarily result in superior performance. Keywords: Levered futures, optimal portfolio performance, constraint investment
BRAIN Α-TOCOPHEROL CONCENTRATION IS INVERSELY ASSOCIATED WITH NEUROFIBRILLARY TANGLE COUNTS IN BRAIN REGIONS AFFECTED IN EARLIER BRAAK STAGES: A CROSS-SECTIONAL FINDING IN THE OLDEST OLD
Objectives: Higher vitamin E status has been associated with lower risk of Alzheimer’s disease (AD). However, evidence of the association of vitamin E concentration in neural tissue with AD pathologies is limited. Design: The cross-sectional relationship between the human brain concentrations of α- and γ-tocopherol and the severity of AD pathologies – neurofibrillary tangle (NFT) and neuritic plaque (NP) – was investigated. Setting & Participants: Brains from 43 centenarians (≥ 98 years at death) enrolled in the Phase III of the Georgia Centenarian Study were collected at autopsy. Measurements: Brain α- and γ-tocopherol concentrations (previously reported) were averaged from frontal, temporal, and occipital cortices. NP and NFT counts (previously reported) were assessed in frontal, temporal, parietal, entorhinal cortices, amygdala, hippocampus, and subiculum. NFT topological progression was assessed using Braak staging. Multiple linear regression was performed to assess the relationship between tocopherol concentrations and NP or NFT counts, with and without adjustment for covariates. Results: Brain α-tocopherol concentrations were inversely associated with NFT but not NP counts in amygdala (β = -2.67, 95% CI [-4.57, -0.79]), entorhinal cortex (β = -2.01, 95% CI [-3.72, -0.30]), hippocampus (β = -2.23, 95% CI [-3.82, -0.64]), and subiculum (β = -2.52, 95% CI [-4.42, -0.62]) where NFT present earlier in its topological progression, but not in neocortices. Subjects with Braak III-IV had lower α-tocopherol (median = 69,622 pmol/g, IQR = 54,389-72,155 pmol/g) than those with Braak I-II (median = 72,108 pmol/g, IQR = 64,056-82,430 pmol/g), but the difference was of borderline significance (p = 0.063). γ-Tocopherol concentrations were not associated with either NFT or NP counts in any brain regions assessed. Conclusions: Higher brain α-tocopherol level is specifically associated with lower NFT counts in brain structures affected in earlier Braak stages. Our findings emphasize the possible importance of α-tocopherol intervention timing in tauopathy progression and warrant future clinical trials
The Hubble Effective Potential
We generalize the effective potential to scalar field configurations which
are proportional to the Hubble parameter of a homogeneous and isotropic
background geometry. This may be useful in situations for which curvature
effects are significant. We evaluate the one loop contribution to the Hubble
Effective Potential for a massless scalar with arbitrary conformal and quartic
couplings, on a background for which the deceleration parameter is constant.
Among other things, we find that inflationary particle production leads to
symmetry restoration at late times.Comment: 32 pages, 6 figures, version 2 published in JCAP with some typoes
corrected and two additional reference
Perspectives in Global Helioseismology, and the Road Ahead
We review the impact of global helioseismology on key questions concerning
the internal structure and dynamics of the Sun, and consider the exciting
challenges the field faces as it enters a fourth decade of science
exploitation. We do so with an eye on the past, looking at the perspectives
global helioseismology offered in its earlier phases, in particular the
mid-to-late 1970s and the 1980s. We look at how modern, higher-quality, longer
datasets coupled with new developments in analysis, have altered, refined, and
changed some of those perspectives, and opened others that were not previously
available for study. We finish by discussing outstanding challenges and
questions for the field.Comment: Invited review; to appear in Solar Physics (24 pages, 6 figures
The influence of media violence on youth
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83429/1/2003.Anderson_etal.InfluenceofMediaViolenceonYouth.PsychologicalScienceinthePublicInterest.pd
Infrared propagator corrections for constant deceleration
We derive the propagator for a massless, minimally coupled scalar on a -dimensional, spatially flat, homogeneous and isotropic background with arbitrary constant deceleration parameter. Our construction uses the operator formalism, by integrating the Fourier mode sum. We give special attention to infrared corrections from the nonzero lower limit associated with working on finite spatial sections. These corrections eliminate infrared divergences that would otherwise be incorrectly treated by dimensional regularization, resulting in off-coincidence divergences for those special values of the deceleration parameter at which the infrared divergence is logarithmic. As an application we compute the expectation value of the scalar stress-energy tensor
Effects of Full Collateralization in Commodity Futures Investments
How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, angiogenesis, immunology and cancer1. Semaphorins/collapsins were characterized in part on the basis of their ability to drastically alter actin cytoskeletal dynamics in neuronal processes2, but despite considerable progress in the identification of semaphorin receptors and their signalling pathways3, the molecules linking them to the precise control of cytoskeletal elements remain unknown. Recently, highly unusual proteins of the Mical family of enzymes have been found to associate with the cytoplasmic portion of plexins, which are large cell-surface semaphorin receptors, and to mediate axon guidance, synaptogenesis, dendritic pruning and other cell morphological changes4, 5, 6, 7. Mical enzymes perform reduction–oxidation (redox) enzymatic reactions4, 5, 8, 9, 10 and also contain domains found in proteins that regulate cell morphology4, 11. However, nothing is known of the role of Mical or its redox activity in mediating morphological changes. Here we report that Mical directly links semaphorins and their plexin receptors to the precise control of actin filament (F-actin) dynamics. We found that Mical is both necessary and sufficient for semaphorin–plexin-mediated F-actin reorganization in vivo. Likewise, we purified Mical protein and found that it directly binds F-actin and disassembles both individual and bundled actin filaments. We also found that Mical utilizes its redox activity to alter F-actin dynamics in vivo and in vitro, indicating a previously unknown role for specific redox signalling events in actin cytoskeletal regulation. Mical therefore is a novel F-actin-disassembly factor that provides a molecular conduit through which actin reorganization—a hallmark of cell morphological changes including axon navigation—can be precisely achieved spatiotemporally in response to semaphorin