The LANDSAT/global positioning system project

A GPSPAC/LANDSAT-D Interface (GLI) Ground Support System was built to validate the performance and to calibrate the accuracy of the experimental navigation package, GPSPAC, flown on the LANDSAT-4 and 5 spacecraft. Although the GLI system operated successfully to give the orbit information needed to validate the GPSPAC, it also detected two anomalies: one is characteristic of the GLI system and the other is characteristic of the pre-operational phase of GPS. Several methods were applied to resolve or reduce the anomalies. This paper presents a description of the problems, the methods applied to resolve or reduce them, and the results

Mission Operations Planning and Scheduling System (MOPSS)

MOPSS is a generic framework that can be configured on the fly to support a wide range of planning and scheduling applications. It is currently used to support seven missions at Goddard Space Flight Center (GSFC) in roles that include science planning, mission planning, and real-time control. Prior to MOPSS, each spacecraft project built its own planning and scheduling capability to plan satellite activities and communications and to create the commands to be uplinked to the spacecraft. This approach required creating a data repository for storing planning and scheduling information, building user interfaces to display data, generating needed scheduling algorithms, and implementing customized external interfaces. Complex scheduling problems that involved reacting to multiple variable situations were analyzed manually. Operators then used the results to add commands to the schedule. Each architecture was unique to specific satellite requirements. MOPSS is an expert system that automates mission operations and frees the flight operations team to concentrate on critical activities. It is easily reconfigured by the flight operations team as the mission evolves. The heart of the system is a custom object-oriented data layer mapped onto an Oracle relational database. The combination of these two technologies allows a user or system engineer to capture any type of scheduling or planning data in the system's generic data storage via a GUI

Use of Open Networks and Delay-Tolerant Protocol to Decrease WAN Latency of EOS near Real-Time Data

Since 1999, NASA's Earth Observing System Data Operations System (EDOS) project at Goddard Space Flight Center (GSFC) has provided high-rate data capture, level zero processing, and product distribution services for a majority of NASA's EOS (Earth Observing System) high-rate missions, including Terra, Aqua, Aura, ICESat, EO-1, SMAP, and OCO-2. EDOS high-rate science and engineering (150-300 Mbps) data-driven capture systems are deployed at 7 worldwide ground stations which are connected via both private (closed) and public (open) wide area networks (WANs) to the centralized EDOS Level Zero Processing Facility (LZPF) located at GSFC, where the data is processed and Level 0 products are distributed to users worldwide. All data transferred over the open networks to GSFC traverse an IPSec tunnel, providing the same level of security as a VPN connection. EDOS produces both time-based and near real-time products (session-based). Near real-time data products are produced from a single ground station contact; time-based products are produced from multiple ground station contacts. EDOS is the primary supplier of EOS Level 0 data to the NASA near real-time user community known as the Land, Atmosphere Near real-time Capability for EOS (LANCE). For the past few years, EDOS has streamlined its systems to reduce WAN latency for near real-time data delivery, including implementing Quality of Service (QoS), expanding closed network bandwidth, adding open network connections with more bandwidth, and implementing a delay-tolerant protocol to mitigate long round-trip times to remote ground stations

EDOS: 20 Years or Level 0 Processing for Terra

No abstract availabl

EDOS Evolution to Support NASA Future Earth Sciences Missions

This paper presents a ground system architecture to service future NASA decadal missions and in particular, the high rate science data downlinks, by evolving EDOS current infrastructure and upgrading high rate network lines. The paper will also cover EDOS participation to date in formulation and operations concepts for the respective missions to understand the particular mission needs and derived requirements such as data volumes, downlink rates, data encoding, and data latencies. Future decadal requirements such as onboard data recorder management and file protocols drive the need to emulate these requirements within the ground system. The EDOS open system modular architecture is scalable to accommodate additional missions using the current sites antennas and future sites as well and meet the data security requirements and fulfill mission's objective

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeric complexes which suggests potential functional redundancy. We previously showed that TRPC3 and TRPC6 double knockout animals have deficits in light touch and hearing whilst single knockouts were apparently normal. We have extended these studies to analyse deficits in global quadruple TRPC1, 3, 5 and 6 null mutant mice. We examined both touch and hearing in behavioural and electrophysiological assays, and provide evidence that the quadruple knockout mice have larger deficits than the TRPC3 TRPC6 double knockouts. Mechano-electrical transducer currents of cochlear outer hair cells were however normal. This suggests that TRPC1, TRPC3, TRPC5 and TRPC6 channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction

Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes

Background: The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the “principal neutralizing domain” of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. Structural and immunochemical data suggest, however, that V3 contains conserved elements which explain its role in binding to virus co-receptors despite its sequence variability. Despite this evidence of V3 conservation, the ability of anti-V3 Abs to neutralize a significant proportion of HIV-1 isolates from different subtypes (clades) has remained controversial. Methods: HIV-1 neutralization experiments were conducted in two independent laboratories to test human anti-V3 monoclonal Abs (mAbs) against pseudoviruses (psVs) expressing Envs of diverse HIV-1 subtypes from subjects with acute and chronic infections. Neutralization was defined by 50% inhibitory concentrations (IC50), and was statistically assessed based on the area under the neutralization titration curves (AUC). Results: Using AUC analyses, statistically significant neutralization was observed by ≥1 anti-V3 mAbs against 56/98 (57%) psVs expressing Envs of diverse subtypes, including subtypes A, AG, B, C and D. Even when the 10 Tier 1 psVs tested were excluded from the analysis, significant neutralization was detected by ≥1 anti-V3 mAbs against 46/88 (52%) psVs from diverse HIV-1 subtypes. Furthermore, 9/24 (37.5%) Tier 2 viruses from the clade B and C standard reference panels were neutralized by ≥1 anti-V3 mAbs. Each anti-V3 mAb tested was able to neutralize 28–42% of the psVs tested. By IC50 criteria, 40/98 (41%) psVs were neutralized by ≥1 anti-V3 mAbs. Conclusions: Using standard and new statistical methods of data analysis, 6/7 anti-V3 human mAbs displayed cross-clade neutralizing activity and revealed that a significant proportion of viruses can be neutralized by anti-V3 Abs. The new statistical method for analysis of neutralization data provides many advantages to previously used analyses

Online exams in higher education: Exploring distance learning students' acceptance and satisfaction

Background Research into online exams in higher education has grown significantly, especially as they became common practice during the COVID-19 pandemic. However, previous studies focused on understanding individual factors that relate to students' dispositions towards online exams in ‘traditional’ universities. Moreover, there is little knowledge on university distance learning students' experience of transitioning from in-person to online exams. Objectives This study investigates the acceptance and satisfaction of university distance learning students in their transitioning from in-person to online exams, through multiple factors. Methods We employed a mixed-methods study to understand the relationship between assessment and online exam factors (e.g., revision and online exam satisfaction, assessment competencies, invigilation acceptance, exam anxiety and workspace satisfaction). Cluster analysis and interview data contributed to our understanding of students who are ‘strongly positive’ and ‘less positive’ towards online exams. Results and Conclusions Our findings highlight the overall importance of increasing student confidence by building their assessment competencies throughout their studies and familiarising them early with the technologies and formats to be used in the actual exam. We also shed light on particular student characteristics that relate to reduced online exam acceptance, such as students with disabilities, caring responsibilities and mental health issues, or students who lack access to the necessary technology. Implications The findings and recommendations of this research contribute to the wider agenda of designing fair and trustworthy online assessment, including exams, for the futur

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at 6p21.32, tagged by rs7192 (P=5.5 × 10 -8) and rs9275596 (P=6.8 × 10 -10), in 2,197 participants of European ancestry. We replicate these associations in an independent sample of European ancestry. These associations are further supported by meta-analyses across the discovery and replication samples. Both single-nucleotide polymorphisms (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (