4,775 research outputs found
Tools for monitoring and controlling distributed applications
The Meta system is a UNIX-based toolkit that assists in the construction of reliable reactive systems, such as distributed monitoring and debugging systems, tool integration systems and reliable distributed applications. Meta provides mechanisms for instrumenting a distributed application and the environment in which it executes, and Meta supplies a service that can be used to monitor and control such an instrumented application. The Meta toolkit is built on top of the ISIS toolkit; they can be used together in order to build fault-tolerant and adaptive, distributed applications
Internet Gambling: An Overview of Psychosocial Impacts
Technological innovation has always played a role in the development of gambling behaviour, primarily through providing new market opportunities. Early prevalence studies of Internet gambling in the UK, Canada and the US have shown that Internet gambling is not a cause for concern at present However, this seems likely to change as more people start to use the Internet for leisure activities. After a brief overview of gambling technologies and deregulation issues, this paper examines the impact of technology on gambling by highlighting salient factors in the rise of Internet gambling (i.e., accessibility, affordability, anonymity, convenience, escape immersion/dissociation, disinhibition, event frequency, asociability, interactivity, and simulation). The paper also overviews some of the main social impacts surrounding Internet gambling, such as protection of the vulnerable, Internet gambling in the workplace, electronic cash, and unscrupulous operators. Recommendations for Internet gambling operators are also provided
In Situ Thermal Decomposition of Exfoliated Two-Dimensional Black Phosphorus
With a semiconducting band gap and high charge carrier mobility,
two-dimensional (2D) black phosphorus (BP), often referred to as phosphorene,
holds significant promise for next generation electronics and optoelectronics.
However, as a 2D material, it possesses a higher surface area to volume ratio
than bulk BP, suggesting that its chemical and thermal stability will be
modified. Herein, an atomic-scale microscopic and spectroscopic study is
performed to characterize the thermal degradation of mechanically exfoliated 2D
BP. From in situ scanning/transmission electron microscopy, decomposition of 2D
BP is observed to occur at ~400 {\deg}C in vacuum, in contrast to the 550
{\deg}C bulk BP sublimation temperature. This decomposition initiates via
eye-shaped cracks along the [001] direction and then continues until only a
thin, amorphous red phosphorous like skeleton remains. In situ electron energy
loss spectroscopy, energy-dispersive X-ray spectroscopy, and energy-loss
near-edge structure changes provide quantitative insight into this chemical
transformation process.Comment: In press: 4 figures in main manuscript, 27 pages with supporting
informatio
Measuring Value in Mediation: A Case Study of Workplace Mediation in City Government
Published in cooperation with the American Bar Association Section of Dispute Resolutio
Capturing Dopaminergic Modulation and Bimodal Membrane Behaviour of Striatal Medium Spiny Neurons in Accurate, Reduced Models
Loss of dopamine from the striatum can cause both profound motor deficits, as in Parkinson's disease, and disrupt learning. Yet the effect of dopamine on striatal neurons remains a complex and controversial topic, and is in need of a comprehensive framework. We extend a reduced model of the striatal medium spiny neuron (MSN) to account for dopaminergic modulation of its intrinsic ion channels and synaptic inputs. We tune our D1 and D2 receptor MSN models using data from a recent large-scale compartmental model. The new models capture the input–output relationships for both current injection and spiking input with remarkable accuracy, despite the order of magnitude decrease in system size. They also capture the paired pulse facilitation shown by MSNs. Our dopamine models predict that synaptic effects dominate intrinsic effects for all levels of D1 and D2 receptor activation. We analytically derive a full set of equilibrium points and their stability for the original and dopamine modulated forms of the MSN model. We find that the stability types are not changed by dopamine activation, and our models predict that the MSN is never bistable. Nonetheless, the MSN models can produce a spontaneously bimodal membrane potential similar to that recently observed in vitro following application of NMDA agonists. We demonstrate that this bimodality is created by modelling the agonist effects as slow, irregular and massive jumps in NMDA conductance and, rather than a form of bistability, is due to the voltage-dependent blockade of NMDA receptors. Our models also predict a more pronounced membrane potential bimodality following D1 receptor activation. This work thus establishes reduced yet accurate dopamine-modulated models of MSNs, suitable for use in large-scale models of the striatum. More importantly, these provide a tractable framework for further study of dopamine's effects on computation by individual neurons
Token Coherence: A New Framework for Shared-Memory Multiprocessors
Commercial workload and technology trends are pushing existing shared-memory multiprocessor coherence protocols in divergent directions. Token Coherence provides a framework for new coherence protocols that can reconcile these opposing trends
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