Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines.

The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk

Synthesising and utilising complex evidence to inform policy in education and health.

Oslo, Norway, May 19 to 21, 200

Random Feature Maps via a Layered Random Projection (LaRP) Framework for Object Classification

The approximation of nonlinear kernels via linear feature maps has recently gained interest due to their applications in reducing the training and testing time of kernel-based learning algorithms. Current random projection methods avoid the curse of dimensionality by embedding the nonlinear feature space into a low dimensional Euclidean space to create nonlinear kernels. We introduce a Layered Random Projection (LaRP) framework, where we model the linear kernels and nonlinearity separately for increased training efficiency. The proposed LaRP framework was assessed using the MNIST hand-written digits database and the COIL-100 object database, and showed notable improvement in object classification performance relative to other state-of-the-art random projection methods.Comment: 5 page

Surface roughness influence on the quality factor of high frequency nanoresonators

Surface roughness influences significantly the quality factor of high frequency nanoresonators for large frequency - relaxation times within the non-Newtonian regime, where a purely elastic dynamics develops. It is shown that the influence of sort wavelength roughness, which is expressed by the roughness exponent H for the case of self-affine roughness, plays significant role in comparison with the effect of the long wavelength roughness parameters such as the rms roughness amplitude and the lateral roughness correlation length. Therefore, the surface morphology can play important role in designing high-frequency resonators operating within the non-Newtonian regime.Comment: 13 pages, 4 figures, To appear in J. Appl. Phys. (2008

The mystery of the 'Kite' radio source in Abell 2626: insights from new Chandra observations

We present the results of a new Chandra study of the galaxy cluster A2626. The radio emission of the cluster shows a complex system of four symmetric arcs without known correlations with the X-ray emission. The mirror symmetry of the radio arcs toward the center and the presence of two optical cores in the central galaxy suggested that they may be created by pairs of precessing radio jets powered by dual AGNs inside the cD galaxy. However, previous observations failed to observe the second jetted AGN and the spectral trend due to radiative age along the radio arcs, thus challenging this interpretation. The new Chandra observation had several scientific objectives, including the search for the second AGN that would support the jet precession model. We focus here on the detailed study of the local properties of the thermal and non-thermal emission in the proximity of the radio arcs, in order to get more insights into their origin. We performed a standard data reduction of the Chandra dataset deriving the radial profiles of temperature, density, pressure and cooling time of the intra-cluster medium. We further analyzed the 2D distribution of the gas temperature, discovering that the south-western junction of the radio arcs surrounds the cool core of the cluster. We studied the X-ray SB and spectral profiles across the junction, finding a cold front spatially coincident with the radio arcs. This may suggest a connection between the sloshing of the thermal gas and the nature of the radio filaments, raising new scenarios for their origin. A possibility is that the radio arcs trace the projection of a complex surface connecting the sites where electrons are most efficiently reaccelerated by the turbulence that is generated by the gas sloshing. In this case, diffuse emission embedded by the arcs and with extremely steep spectrum should be most visible at very low radio frequencies.Comment: 7 pages, 7 figures. Accepted for publication on A&

X-ray Observations of Parsec-Scale Tails behind Two Middle-Aged Pulsars

Chandra and XMM-Newton resolved extremely long tails behind two middle-aged pulsars, J1509-5850 and J1740+1000. The tail of PSR J1509-5850 is discernible up to 5.6' from the pulsar (6.5 pc at a distance of 4 kpc), with a flux of 2*10^{-13} erg s^{-1} cm^{-2} in 0.5-8 keV. The tail spectrum fits an absorbed power-law (PL) model with the photon index of 2.3\pm0.2, corresponding to the 0.5-8 keV luminosity of 1*10^{33} ergs s^{-1}, for n_H= 2.1*10^{22} cm^{-2}. The tail of PSR J1740+1000 is firmly detected up to 5' (2 pc at a 1.4 kpc distance), with a flux of 6*10^{-14} ergs cm^{-2} s^{-1} in 0.4-10 keV. The PL fit yields photon index of 1.4-1.5 and n_H=1*10^{21} cm^{-2}. The large extent of the tails suggests that the bulk flow in the tails starts as mildly relativistic downstream of the termination shock, and then gradually decelerates. Within the observed extent of the J1509-5850 tail, the average flow speed exceeds 5,000 km s^{-1}, and the equipartition magnetic field is a few times 10^{-5} G. For the J1740+1000 tail, the equipartition field is a factor of a few lower. The harder spectrum of the J1740+1000 tail implies either less efficient cooling or a harder spectrum of injected electrons. For the high-latitude PSR J1740+1000, the orientation of the tail on the sky shows that the pulsar is moving toward the Galactic plane, which means that it was born from a halo-star progenitor. The comparison between the J1509 and J1740 tails and the X-ray tails of other pulsars shows that the X-ray radiation efficiency correlates poorly with the pulsar spin-down luminosity or age. The X-ray efficiencies of the ram-pressure confined pulsar wind nebulae (PWNe) are systematically higher than those of PWNe around slowly moving pulsars with similar spin-down parameters.Comment: 14 pages, 16 figures and 5 table

Perspective on Quark Mass and Mixing Relations

Recent data indicate that $V_{ub}\cong \lambda^4 \cong (0.22)^4$, while $m_t$ seems to be $174$ GeV. The relations $m_d/m_s\sim m_s/m_b \sim \delta \sim \lambda^2 \simeq \vert V_{cb}\vert$ and $m_u/m_c\sim m_c/m_t \sim \delta^2 \sim \lambda^4 \sim \vert V_{ub}\vert$ suggest that %a plausible clean separation of the %origin of the quark mixing matrix: the down type sector is responsible for $\vert V_{us}\vert$ and $\vert V_{cb}\vert$, while $V_{ub}$ comes from the up type sector. Five to six parameters might suffice to account for the ten quark mass and mixing parameters, resulting in specific power series representations for the mass matrices. In this picture, $\delta$ seems to be the more sensible expansion parameter, while $\lambda \cong \sqrt{m_d/m_s} \sim \sqrt{\delta}$ is tied empirically to $(M_d)_{11} = 0$.Comment: 10 pages, ReVtex, no figure

Pion Interferometry for a Granular Source of Quark-Gluon Plasma Droplets

We examine the two-pion interferometry for a granular source of quark-gluon plasma droplets. The evolution of the droplets is described by relativistic hydrodynamics with an equation of state suggested by lattice gauge results. Pions are assumed to be emitted thermally from the droplets at the freeze-out configuration characterized by a freeze-out temperature $T_f$. We find that the HBT radius $R_{out}$ decreases if the initial size of the droplets decreases. On the other hand, $R_{side}$ depends on the droplet spatial distribution and is relatively independent of the droplet size. It increases with an increase in the width of the spatial distribution and the collective-expansion velocity of the droplets. As a result, the value of $R_{out}$ can lie close to $R_{side}$ for a granular quark-gluon plasma source. The granular model of the emitting source may provide an explanation to the RHIC HBT puzzle and may lead to a new insight into the dynamics of the quark-gluon plasma phase transition.Comment: 5 pages, 4 figure

Pauli susceptibility of nonadiabatic Fermi liquids

The nonadiabatic regime of the electron-phonon interaction leads to behaviors of some physical measurable quantities qualitatively different from those expected from the Migdal-Eliashberg theory. Here we identify in the Pauli paramagnetic susceptibility $\chi$ one of such quantities and show that the nonadiabatic corrections reduce $\chi$ with respect to its adiabatic limit. We show also that the nonadiabatic regime induces an isotope dependence of $\chi$, which in principle could be measured.Comment: 7 pages, 3 figures, euromacr.tex, europhys.sty. Replaced with accepted version (Europhysics Letters