Using Tracker as a Pedagogical Tool for Understanding Projectile Motion

This paper reports the use of Tracker as a pedagogical tool in the effective learning and teaching of projectile motion in physics. When computer model building learning processes is supported and driven by video analysis data, this free Open Source Physics (OSP) tool can provide opportunities for students to engage in active inquiry-based learning. We discuss the pedagogical use of Tracker to address some common misconceptions of projectile motion by allowing students to test their hypothesis by juxtaposing their mental models against the analysis of real life videos. Initial research findings suggest that allowing learners to relate abstract physics concepts to real life through coupling computer modeling with traditional video analysis could be an innovative and effective way to learn projectile motion. 2015 Resources: http://iwant2study.org/ospsg/index.php/interactive-resources/physics/02-newtonian-mechanics/01-kinematics/174-projectile-motionComment: 9 pages, 9 figures; http://iopscience.iop.org/0031-9120/47/4/44

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits breast cancer development through downregulating epithelial-mesenchymal transition (EMT) and stemness-associated genes. Quantitative multiplexed Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (qPLEX-RIME) further reveals a significant rewiring of NELF-E-associated chromatin partners as a function of EMT and a co-option of NELF-E with the key EMT transcription factor SLUG. Accordingly, loss of NELF-E leads to impaired SLUG binding on chromatin. Through integrative transcriptomic and genomic analyses, we identify the histone acetyltransferase, KAT2B, as a key functional target of NELF-E-SLUG. Genetic and pharmacological inactivation of KAT2B ameliorate the expression of EMT markers, phenocopying NELF ablation. Elevated expression of NELF-E and KAT2B is associated with poorer prognosis in breast cancer patients, highlighting the clinical relevance of our findings. Taken together, we uncover a crucial role of the NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

Validation of the care transition measure in multi-ethnic South-East Asia in Singapore

10.1186/1472-6963-12-256BMC Health Services Research121

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Joint flexion/extension angle estimation using ultra-wideband (UWB) radios

Joint flexion/extension angle measurement is known to be of clinical importance. It is essential for investigating complex gait disorders and monitoring of process in rehabilitation. Comparing with many other measuring methods such as mechanical, visual, audio, radar magnetic and inertial tracking, wearable Ultra Wideband (UWB) is the best candidate for human motion tracking due to its high ranging and positioning accuracy, low cost, less power consumption and robust performance in various environments. The system is also much smaller as compared with other existing approaches. The purpose of this report is to present a wearable system for estimating human elbow or knee joint flexion/extension angle using Ultra Wideband radios. UWB radio is an electromagnetic waveform formed by a sequence of very short pulses. A UWB transmitting antenna and a receiving antenna were placed on human elbow or knee adjacent segments. A Goniometer will be attached on human joint together with the UWB transceivers to ensure that the measurement could be conducted under same reference frame for comparison. The estimated distances were calculated between transmitter and receiver through the estimation of propagation delay, using Time of arrival (TOA) of the first arrival path. This method is the most common method to estimate the distance. The estimated distance was used to estimate the joint flexion/extension angle and also the static measurement of the adjacent segments length of the arm or legs by applying law of cosines. The performance of this wearable UWB based system was compared with the goniometer by simultaneously measuring elbow joint angle at three different moving speeds: slow, normal, fast. The experimental results demonstrate that the system has reasonable performance with a slightly increase in error as the speed increases. The system is capable of taking indoor and outdoor measurements. This system can also replace the goniometer system for rehabilitation. It is shown that the system has sufficient accuracy for clinical applications.Bachelor of Engineerin

FACTORS INFLUENCING THE PRODUCTION OF CHINESE DRAMA SERIALS IN SINGAPORE

Bachelor'sBACHELOR OF SOCIAL SCIENCES (HONOURS

The greying workforce in Singapore.

The workforce in Singapore is ageing rather rapidly. Literature review of other countries indicates that the older workers are perceived negatively, i.e., there is negative stereotyping of their performance as compared to their younger colleagues. The younger workers are perceived to perform better than their older cohort.Master of Business Administration (Accountancy

Influence of bonus and creative rewards on creative outputs and creative risks

Creativity has been identified by many as the key to successful strategy formulation and implementation. To some firms, this can mean gaining a competitive advantage, to others,this might be the crucial tool for survival. This study examines the impact that goal-attainment bonus schemes and rewards for creative actions have on the willingness of an average managerial employee to take risks, explore possibilities and respond to hunches thus generating creative outcomes