Precise B, B_s and B_c meson spectroscopy from full lattice QCD

We give the first accurate results for $B$ and $B_s$ meson masses from lattice QCD including the effect of $u$, $d$ and $s$ sea quarks, and we improve an earlier value for the $B_c$ meson mass. By using the Highly Improved Staggered Quark action for $u/d$, $s$ and $c$ quarks and NRQCD for the $b$ quarks, we are able to achieve an accuracy in the masses of around 10 MeV. Our results are: $m_B$ = 5.291(18) GeV, $m_{B_s}$ = 5.363(11) GeV and $m_{B_c}$ = 6.280(10) GeV. Note that all QCD parameters here are tuned from other calculations, so these are parameter free tests of QCD against experiment. We also give scalar, $B_{s0}^*$, and axial vector, $B_{s1}$, meson masses. We find these to be slightly below threshold for decay to $BK$ and $B^*K$ respectively.Comment: 22 pages, 19 figure

Generic searches for alternative gravitational wave polarizations with networks of interferometric detectors

The detection of gravitational wave signals by Advanced LIGO and Advanced Virgo enables us to probe the polarization content of gravitational waves. In general relativity, only tensor modes are present, while in a variety of alternative theories one can also have vector or scalar modes. Recently test were performed which compared Bayesian evidences for the hypotheses that either purely tensor, purely vector, or purely scalar polarizations were present. Indeed, with only three detectors in a network and allowing for mixtures of tensor polarizations and alternative polarization states, it is not possible to identify precisely which nonstandard polarizations might be in the signal and by what amounts. However, we demonstrate that one can still infer whether, in addition to tensor polarizations, alternative polarizations are present in the first place, irrespective of the detailed polarization content. We develop two methods to do this for sources with electromagnetic counterparts, both based on the so-called null stream. Apart from being able to detect mixtures of tensor and alternative polarizations, these have the added advantage that no waveform models are needed, and signals from any kind of transient source with known sky position can be used. Both formalisms allow us to combine information from multiple sources so as to arrive at increasingly more stringent bounds. For now we apply these on the binary neutron star signal GW170817, showing consistency with the tensor-only hypothesis with p-values of 0.315 and 0.790 for the two methods

Generic searches for alternative gravitational wave polarizations with networks of interferometric detectors

The detection of gravitational wave signals by Advanced LIGO and Advanced Virgo enables us to probe the polarization content of gravitational waves. In general relativity, only tensor modes are present, while in a variety of alternative theories one can also have vector or scalar modes. Recently test were performed which compared Bayesian evidences for the hypotheses that either purely tensor, purely vector, or purely scalar polarizations were present. Indeed, with only three detectors in a network and allowing for mixtures of tensor polarizations and alternative polarization states, it is not possible to identify precisely which non-standard polarizations might be in the signal and by what amounts. However, we demonstrate that one can still infer whether, in addition to tensor polarizations, alternative polarizations are present in the first place, irrespective of the detailed polarization content. We develop two methods to do this for sources with electromagnetic counterparts, both based on the so-called null stream. Apart from being able to detect mixtures of tensor and alternative polarizations, these have the added advantage that no waveform models are needed, and signals from any kind of transient source with known sky position can be used. Both formalisms allow us to combine information from multiple sources so as to arrive at increasingly more stringent bounds. For now we apply these on the binary neutron star signal GW170817, showing consistency with the tensor-only hypothesis with p-values of 0.315 and 0.790 for the two methods.Comment: 8 pages, 3 figure

Low Temperature Opacities

Previous computations of low temperature Rosseland and Planck mean opacities from Alexander & Ferguson (1994) are updated and expanded. The new computations include a more complete equation of state with more grain species and updated optical constants. Grains are now explicitly included in thermal equilibrium in the equation of state calculation, which allows for a much wider range of grain compositions to be accurately included than was previously the case. The inclusion of high temperature condensates such as Al$_2$O$_3$ and CaTiO$_3$ significantly affects the total opacity over a narrow range of temperatures before the appearance of the first silicate grains. The new opacity tables are tabulated for temperatures ranging from 30000 K to 500 K with gas densities from 10$^{-4}$ g cm$^{-3}$ to 10$^{-19}$ g cm$^{-3}$. Comparisons with previous Rosseland mean opacity calculations are discussed. At high temperatures, the agreement with OPAL and Opacity Project is quite good. Comparisons at lower temperatures are more divergent as a result of differences in molecular and grain physics included in different calculations. The computation of Planck mean opacities performed with the opacity sampling method are shown to require a very large number of opacity sampling wavelength points; previously published results obtained with fewer wavelength points are shown to be significantly in error. Methods for requesting or obtaining the new tables are provided.Comment: 39 pages with 12 figures. To be published in ApJ, April 200

“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β‑Synthase Inhibitor that Attenuates Cellular H\u3csub\u3e2\u3c/sub\u3eS Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

The gaseous neuromodulator H2S is associated with neuronal cell death pursuant to cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H2S biogenesis in the brain, it has emerged as a potential target for the treatment of stroke. Herein, a “zipped” approach by alkene cross-metathesis into CBS inhibitor candidate synthesis is demonstrated. The inhibitors are modeled after the pseudo-C2-symmetric CBS product (L,L)-cystathionine. The “zipped” concept means only half of the inhibitor needs be constructed; the two halves are then fused by olefin cross-metathesis. Inhibitor design is also mechanism-based, exploiting the favorable kinetics associated with hydrazine-imine interchange as opposed to the usual imine−imine interchange. It is demonstrated that the most potent “zipped” inhibitor 6S reduces H2S production in SHSY5Y cells overexpressing CBS, thereby reducing cell death. Most importantly, CBS inhibitor 6S dramatically reduces infarct volume (1 h post-stroke treatment; ∼70% reduction) in a rat transient middle cerebral artery occlusion model for ischemia. Supplementary information (112 pp.) is attached (below)

“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β‑Synthase Inhibitor that Attenuates Cellular H\u3csub\u3e2\u3c/sub\u3eS Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

The gaseous neuromodulator H2S is associated with neuronal cell death pursuant to cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H2S biogenesis in the brain, it has emerged as a potential target for the treatment of stroke. Herein, a “zipped” approach by alkene cross-metathesis into CBS inhibitor candidate synthesis is demonstrated. The inhibitors are modeled after the pseudo-C2-symmetric CBS product (L,L)-cystathionine. The “zipped” concept means only half of the inhibitor needs be constructed; the two halves are then fused by olefin cross-metathesis. Inhibitor design is also mechanism-based, exploiting the favorable kinetics associated with hydrazine-imine interchange as opposed to the usual imine−imine interchange. It is demonstrated that the most potent “zipped” inhibitor 6S reduces H2S production in SHSY5Y cells overexpressing CBS, thereby reducing cell death. Most importantly, CBS inhibitor 6S dramatically reduces infarct volume (1 h post-stroke treatment; ∼70% reduction) in a rat transient middle cerebral artery occlusion model for ischemia. Supplementary information (112 pp.) is attached (below)

Abdominal aortic calcification, bone mineral density and fractures: a systematic review and meta-analysis protocol

INTRODUCTION: Abdominal aortic calcification (AAC) is associated with low bone mass and increased fracture risk. Two previous meta-analyses have investigated the association between AAC and fracture. However, these meta-analyses only identified articles until December 2016, undertook limited searches and did not explore potential sources of between-study heterogeneity. We aim to undertake a sensitive and comprehensive assessment of the relationship between AAC, bone mineral density (BMD) as well as prevalent and incident fractures. METHODS: We will search MEDLINE, EMBASE, Web of Science core collection and Google Scholar (top 200 articles sorted by relevance) from their inception to 1 June 2018. Reference lists of included studies and previous systematic reviews will be hand searched for additional eligible studies. Retrospective and prospective cohort studies (cross-sectional, case-control and longitudinal) reporting the association between AAC, BMD and fracture at any site will be included. At least two investigators will independently: (A) evaluate study eligibility and extract data, with a third investigator to adjudicate when discrepancies occur, (B) assess study quality by the Newcastle-Ottawa Scale for each cohort/study. The meta-analysis will be reported in adherence to the Meta-analysis of Observational Studies in Epidemiology criteria. AAC will be grouped as either: (1) AAC present or absent, (2) AAC categorised as \u27low\u27 (referent-lowest reported group) versus \u27high\u27 (all other groups) or (3) dose-response when AAC was assessed in ≥3 groups. Where primary event data were reported in individual studies, pooled risk differences and risk ratios with 95% CI will be calculated, from which, a summary estimate will be determined using DerSimonian-Laird random effects models. For the AAC and BMD pooled analyses, estimates will be expressed as standardised mean difference with 95% CI. We will examine the likelihood of publication bias and where possible, investigate potential reasons for between-study heterogeneity using subgroup analyses and meta-regression. ETHICS AND DISSEMINATION: The study will be submitted to a peer- reviewed journal and disseminated via research presentations. PROSPERO REGISTRATION NUMBER: CRD42018088019

Relativistic Calculation of the Meson Spectrum: a Fully Covariant Treatment Versus Standard Treatments

A large number of treatments of the meson spectrum have been tried that consider mesons as quark - anti quark bound states. Recently, we used relativistic quantum "constraint" mechanics to introduce a fully covariant treatment defined by two coupled Dirac equations. For field-theoretic interactions, this procedure functions as a "quantum mechanical transform of Bethe-Salpeter equation". Here, we test its spectral fits against those provided by an assortment of models: Wisconsin model, Iowa State model, Brayshaw model, and the popular semi-relativistic treatment of Godfrey and Isgur. We find that the fit provided by the two-body Dirac model for the entire meson spectrum competes with the best fits to partial spectra provided by the others and does so with the smallest number of interaction functions without additional cutoff parameters necessary to make other approaches numerically tractable. We discuss the distinguishing features of our model that may account for the relative overall success of its fits. Note especially that in our approach for QCD, the resulting pion mass and associated Goldstone behavior depend sensitively on the preservation of relativistic couplings that are crucial for its success when solved nonperturbatively for the analogous two-body bound-states of QED.Comment: 75 pages, 6 figures, revised content