Characterising the biological function of constitutive androstane receptor and its possible role in liver cancer

Constitutive androstane receptor (CAR) is a xenosensor that is almost exclusively expressed in liver. Studies in rodents suggest an oncogenic role for CAR in liver cancer, but its role in human liver cancer is unclear. This study investigated the functional roles of CAR in human liver cancer with a focus on the liver cancer stem cell (LCSCs) using siRNA, modulation of CAR activity by its specific agonist, and tumour sphere formation assays. CAR expression was significantly reduced in human liver cancer. Based on bioinformatic analyses and in vitro studies, activation of CAR significantly reduces cancer cell stemness and represses proliferation, migration, invasion, and the tumour sphere-forming abilities of liver cancer cells (p<0.05). CAR increased the expression of stemness markers CD24 and/or CD133 (p<0.05) in liver cancer cells. Collectively, CAR acts a tumour suppressor role in human liver cancer

Gene therapy for osteoporosis

Osteoporosis is considered one of the most common and serious problems affecting the elderly population worldwide. It is a chronic and progressive disease, characterized by decreased bone mass and degeneration of the microarchitecture of the bone tissue. Gene therapy represents a new approach in osteoporosis treatment, and its main function is to restore the compromised function in the metabolism. This review aims to elucidate the main studies on gene therapy in recent years, in the medical databases, that use gene therapy for the treatment of osteoporosis in animal models, as well as the future prospects of this therapy. The majority of the studies use the BMP, PTH and OPG genes, in an attempt to reestablish bone mass. Despite the lack of new molecules, all genes employed in these studies have proven to be efficient in the treatment of the disease. The benefits that gene therapy will provide for patients in the future should contribute substantially to increasing the quality of life for the elderly. Soon, clinical trials involving humans will benefit individuals with osteoporosis.A osteoporose é considerada um dos problemas de saúde mais comuns e sérios da população idosa mundial. É uma doença crônica e progressiva, caracterizada pela diminuição da massa óssea e deterioração da microarquitetura do tecido ósseo. A terapia gênica representa uma nova abordagem para o tratamento da osteoporose e tem como princípio devolver a função comprometida pelo metabolismo. Esta revisão visa focar os trabalhos relevantes desenvolvidos nos últimos anos, disponibilizados nas bases de dados médicas, e que utilizaram a terapia gênica para o tratamento da osteoporose em modelos animais, bem como, as perspectivas futuras desta terapia. A maioria dos estudos utiliza os genes BMPs, PTH e OPG na tentativa de restabelecer a massa óssea. Apesar da carência de novas moléculas, todos os genes empregados nos estudos se mostraram eficientes no tratamento da doença. Os benefícios que a terapia gênica proporcionará aos pacientes no futuro devem contribuir substancialmente para o aumento na qualidade de vida dos idosos. Em breve, protocolos clínicos envolvendo humanos irão beneficiar os indivíduos com osteoporose.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Preparation, characterization and photocatalytic behavior of WO3-fullerene/TiO2 catalysts under visible light

WO3-treated fullerene/TiO2 composites (WO3-fullerene/TiO2) were prepared using a sol-gel method. The composite obtained was characterized by BET surface area measurements, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, and UV-vis analysis. A methyl orange (MO) solution under visible light irradiation was used to determine the photocatalytic activity. Excellent photocatalytic degradation of a MO solution was observed using the WO3-fullerene, fullerene-TiO2, and WO3-fullerene/TiO2 composites under visible light. An increase in photocatalytic activity was observed, and WO3-fullerene/TiO2 has the best photocatalytic activity; it may attribute to the increase of the photo-absorption effect by the fullerene and the cooperative effect of the WO3

Enhanced Electrochemical Performances of Hollow-Structured N-Doped Carbon Derived from a Zeolitic Imidazole Framework (ZIF-8) Coated by Polydopamine as an Anode for Lithium-Ion Batteries

Doping heteroatoms such as nitrogen (N) and boron (B) into the framework of carbon materials is one of the most efficient methods to improve the electrical performance of carbon-based electrodes. In this study, N-doped carbon has been facilely synthesized using a ZIF-8/polydopamine precursor. The polyhedral structure of ZIF-8 and the effective surface-coating capability of dopamine enabled the formation of N-doped carbon with a hollow structure. The ZIF-8 polyhedron served as a sacrificial template for hollow structures, and dopamine participated as a donor of the nitrogen element. When compared to ZIF-8-derived carbon, the HSNC electrode showed an improved reversible capacity of approximately 1398 mAh·g−1 after 100 cycles, with excellent cycling retention at a voltage range of 0.01 to 3.0 V using a current density of 0.1 A·g−1

Relationship between Mothers' Diagnosis of Cervical Cancer and Attitudes toward Preventing Cervical Cancer in Their Pubertal Daughters

PURPOSE: This study was conducted to examine the relationship between a mother&apos;s diagnosis of cervical cancer and attitudes toward cervical cancer prevention in their daughters. Their intention to recommend human papillomavirus (HPV) vaccination for their daughters, their confidence in 8 methods for cervical cancer prevention with their daughters, and their negative emotions about the assumption of their daughter&apos;s HPV infection. METHODS: This study was a secondary analysis of data from the study of maternal health beliefs about preventing cervical cancer. The study sample were women who reported whether ever diagnosed with cervical cancer, who had pubertal daughters (n=1,578). Data were analyzed by cross-tabulation analysis, Spearman&apos;s rank correlation analysis, and logistic regression. RESULTS: Mothers diagnosed with cervical cancer were more confident in using methods to prevent cervical cancer in their daughters (Z=−4.42, p&amp;lt;.001) and were more likely to feel negative emotions about the assumption of their daughters&apos; HPV infection (Z=−2.44, p=.015) than mothers who were not diagnosed. Significant factors influencing their intention to recommend the HPV vaccination to their daughters were the mother&apos;s confidence in preventing cervical cancer in their daughters (odds ratio [OR], 1.003; 95% confidence interval [CI], 1.002–1.004) and their negative emotions about the assumption of their daughters&apos; HPV infection (OR,1.016; 95% CI, 1.004–1.028). CONCLUSION: For the early prevention of cervical cancer in pubertal daughters, the education of their mothers should include interventions to increase confidence in preventing cervical cancer in their daughters and sensitivity of HPV infection toward daughters

SkyMapper Southern Survey: First Data Release (DR1)

We present the first data release (DR1) of the SkyMapper Southern Survey, a hemispheric survey carried out with the SkyMapper Telescope at Siding Spring Observatory in Australia. Here, we present the survey strategy, data processing, catalogue construction and database schema. The DR1 dataset includes over 66,000 images from the Shallow Survey component, covering an area of 17,200 deg$^2$ in all six SkyMapper passbands $uvgriz$, while the full area covered by any passband exceeds 20,000 deg$^2$. The catalogues contain over 285 million unique astrophysical objects, complete to roughly 18 mag in all bands. We compare our $griz$ point-source photometry with PanSTARRS1 DR1 and note an RMS scatter of 2%. The internal reproducibility of SkyMapper photometry is on the order of 1%. Astrometric precision is better than 0.2 arcsec based on comparison with Gaia DR1. We describe the end-user database, through which data are presented to the world community, and provide some illustrative science queries.Comment: 31 pages, 19 figures, 10 tables, PASA, accepte

Individual mean-variance relation and stock-level investor sentiment

This research studies the effect of stock-level investor sentiment on individual stock returns’ mean-variance relation. Using unique buy and sell volume data of retail investors in Korean stock market, we find that a positive mean-variance relation is undermined among high-sentiment stocks, but holds among low-sentiment stocks. We adopt buy-sell imbalances of retail investors for individual stocks as a measure of stock-level investor sentiment. Further, our findings provide empirical evidence of a strong riskreturn trade-off among stocks with low retail concentration (e.g., large capitalization, high-priced, and growth stocks). Existing research only analyzes market-wide investor sentiment. However, we study the effect of stock-level investor sentiment on individual stock returns. Therefore, our findings suggest novel implications about the investment strategy that the stock-level investor sentiment is important when constructing portfolios based on variance

Acute respiratory distress after metofluthrin insecticide ingestion in a 19-month-old girl

Metofluthrin is a volatile pyrethroid insecticide. Despite being widely used as a safe household insecticide, it could cause severe systemic symptoms. A 19-month-old girl was taken to the emergency department after ingesting 1 mL of a mosquito repellent containing metofluthrin. After the arrival, the girl developed respiratory distress, which worsened progressively despite the administration of oxygen with nebulized salbutamol and budesonide. Additionally, she underwent application of high-flow nasal cannula, and administration of activated charcoal and systemic steroids. Her dyspnea gradually improved, and she was thus discharged on day 4 with oral prednisolone. All medications were discontinued 10 days after the discharge without any complication. Respiratory distress can develop after the ingestion of even a small amount of metofluthrin. Symptomatic and adjunctive steroid therapies can be effective therapeutic options

SkyMapper Southern Survey: Second Data Release (DR2)

We present the second data release (DR2) of the SkyMapper Southern Survey, a hemispheric survey carried out with the SkyMapper Telescope at Siding Spring Observatory in Australia, using six optical filters: $u,v,g,r,i,z$. DR2 is the first release to go beyond the $\sim$18mag (10${\sigma}$) limit of the Shallow Survey released in DR1, and includes portions of the sky at full survey depth that reach >21mag in $g$ and $r$ filters. The DR2 photometry has a precision as measured by internal reproducibility of 1% in $u$ and $v$, and 0.7% in $griz$. More than 21 000 deg$^2$ have data in some filters (at either Shallow or Main Survey depth) and over 7 000 deg$^2$ have deep Main Survey coverage in all six filters. Finally, about 18 000 deg$^2$ have Main Survey data in $i$ and $z$ filters, albeit not yet at full depth. The release contains over 120 000 images, as well as catalogues with over 500 million unique astrophysical objects and nearly 5 billion individual detections. It also contains cross-matches with a range of external catalogues such as Gaia DR2, Pan-STARRS1 DR1, GALEX GUVcat, 2MASS, and AllWISE, as well as spectroscopic surveys such as 2MRS, GALAH, 6dFGS, and 2dFLenS.Comment: 21 pages, 17 figures. As of 25 Aug 2020, DR2 is available to the world at http://skymapper.anu.edu.a