2020-05-13 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: APS virtual graduation. NM Governor update. Free testing for all. NM 2020 census challenges. BCBS $1M COVID-19 donation. NM case count. Most tribes infected. Increased NM Medicaid enrollment. UNM revenue losses. UNM limited operations continue. No dine-in eating yet. Clothing store reopening measures. Aid package. Consumer prices tumble. Public guidance adherence survey. Healthcare resource prediction. Food insecurity. Supply system comparison. Pentagon PPE award. Ensemble mortality model. 4.4% French infections. Asymptomatic spread. Traffic infection correlation. Comorbid COPD/smoking mortality. Airplane transmission contained. CDC COVID-19 statistics. WHO: endemic virus risk. Iceland tracking app impact. WHO: prison management. Quality of life. Containment amongst HCWs. Emotional regulation. Literature overload coping. Exercise and well-being. Information sources. Distress among healthcare students. Expanding pharmacy role. Recommendations on sedation in mechanical ventilation. Long-acting antipsychotics usage. Comorbidities and mortality. Continuing clinical trials. Short interval re-testing. Pharynx gargle samples. BCG vaccination not protective. Plasmapheresis case series. Convalescent plasma safety. Neutralizing antibodies. 40 new trials. Acute kidney injury. Multiorgan and renal tropism. Intestinal cell infections. Cardiovascular disease risk link. Cutaneous manifestations. Underpowered studies

2020-04-30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM residential facility deaths. NM case update. NM TriCore testing antibodies. Navajo nation cases. May 10 Navajo peak. Udall funding push. El Paso shopping discouraged. NM budget shortfall. Santa Fe furlough. Ethanol sanitizer safety. LA free testing for all. Michigan protest. NM Batelle N95 decontamination. Hospital revenue decline. Wastewater early detection. German herd immunity. 60-day viral shedding possible. Temporary infected “ark”. Prison release preparedness. Low quality research. Phased long-term care. Suicide prevention. Corticosteroid tradeoffs. Cloth mask guidelines. SARS-CoV-2 assays compared. IgG and viral loads. Better testing reporting. Dubious testing vendors. Promising oral drug. Hydroxychloroquine prophylaxis dosing. Umifenovir ineffective. Multi-drug nanoparticles. Drug discovery new targets. 38 new COVID-19 trials. Cancer research review. Attenuated SARS-CoV-2

2020-05-04 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM convalescent plasma call. NM case counts. Gallup lockdown continues. Tribal federal relief delay. Childcare demand drops. Polling open for primaries. Non-US world funds R&D. South Korea eases more. Soft quarantine inefficiency. Chinese interventions. Transmission window. December French case. CDC on law enforcement, essential errands. NEJM on telemedicine. Practice guidelines for: ECMO, pneumonia, nuclear medicine SOP. FDA antibody test restrictions. Africa testing differences. PCR assay sensitivity. Wuhan antibody tracking. Hydroxychloroquine toxicity. Remdesivir mechanism. Tocilzumab study inconclusive. SARs-CoV-2 structure. 28 new trials. Immunology and exercise. Synthetic SARS-CoV-2. IgM and IgG responses. Bacterial and fungal coinfection. Youth mental health challenges

GagCM9-Specific CD8+ T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo

Several lines of evidence suggest that HIV/SIV-specific CD8+ T cells play a critical role in the control of viral replication. Recently we observed high levels of viremia in Indian rhesus macaques vaccinated with a segment of SIVmac239 Gag (Gag45–269) that were subsequently infected with SIVsmE660. These seven Mamu-A*01+ animals developed CD8+ T cell responses against an immunodominant epitope in Gag, GagCM9, yet failed to control virus replication. We carried out a series of immunological and virological assays to understand why these Gag-specific CD8+ T cells could not control virus replication in vivo. GagCM9-specific CD8+ T cells from all of the animals were multifunctional and were found in the colonic mucosa. Additionally, GagCM9-specific CD8+ T cells accessed B cell follicles, the primary residence of SIV-infected cells in lymph nodes, with effector to target ratios between 20–250 GagCM9-specific CD8+ T cells per SIV-producing cell. Interestingly, vaccinated animals had few public TCR clonotypes within the GagCM9-specific CD8+ T cell population pre- and post-infection. The number of public TCR clonotypes expressed by GagCM9-specific CD8+ T cells post-infection significantly inversely correlated with chronic phase viral load. It is possible that these seven animals failed to control viral replication because of the narrow TCR repertoire expressed by the GagCM9-specific CD8+ T cell population elicited by vaccination and infection

Binocular Diplopia as a Rare Late Complication of Conjunctivoplasty Surgery for Conjunctival Chalasis

Conjunctival chalasis is characterized by excess conjunctival membrane that may cause pain, dryness, and other ocular surface pathology. Conjunctival surgery may be indicated for treatment of symptomatic cases. We present a case of late onset binocular diplopia as a result of corneal conjunctival adhesion due to radiofrequency ablation of conjunctival chalasis

The cognitive contexts of beliefs about the healthiness of meat

Copyright © 2002 CABI Publishin

2020-06-17/18 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case count. UNM housing plan for fall 2020. Navajo Nation health and social inequities. US Highlights: Banning airline passengers. Economics, Workforce, Supply Chain, PPE: COVID-19 Exit Strategy. Effect of extended use respirators and PPE. Epidemiology Highlights: Model predicts effects of strategies on US epidemic. Index for assessing risk of contagion. Practice Guidelines: Institutional antithrombotic protocols in US and France are reviewed. Shortcomings of restricted hospital visitation are discussed. Testing: Current testing strategies and assays. Reducing transmission in incarcerated populations. Drugs, Vaccines, Therapies, Clinical Trials: More detail on dexamethasone trial. Methylprednisolone improved outcomes. Outcomes on ACEI/ARB. 34 new trials. Other Science: Nearly 20% of world’s population is at risk for severe disease. High-flow nasal cannula for acute respiratory failure. Genome-wide association study of patients with severe disease. Frail geriatric COVID-19 patients have a higher risk of delirium. Asymptomatic infection is associated with a longer virus shedding and a weaker immune response

2020-05-07 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM cases. Gallup shutdown extended. Gallup hospital crisis. NM assisted living testing. University student financial relief. FDA fraudulent products. Trump/Pence test negative. India displaced repatriated. Use facemasks. Facemasks cause skin damage. PPE protocol. Michigan reopens. Illegal drug prices up. Failing masks from China. Distribution of remdesivir. CDC PPE video. Low German R0. Stay-at-home lowers Rt. Detention facility epidemiology. Saliva transmission. Healthcare informatics shortcomings. Resource allocation ethics. Uninsured drug discounts. Safer food delivery. Bat coronavirus grant axed. Dispelling common misinformation. Recommendations on managing cardiac arrest, cardiac electrotherapy and electrophysiology, hematologic malignancy, ophthalmologic screening and procedures, the use of ACEIs and ARBs. Post-COVID-19 rehabilitation. Hearing problems in children. Resuming orthopedic surgeries. NM prison testing. Qatar 0.07% mortality. Testing manufacturer nontransparency. Understanding RT-PCR vs. ELISA. Influenza infection control surrogate. 24 FDA drugs in vitro activity. NEJM hydroxychloroquine observational study. Monoclonal antibody in vitro. Lysosomal SARS-CoV-2 insights. Chloropromazine inhibits replication. Avoid HCQ in schizophrenia. Alkaloid/terpenoid protease inhibitors. Virus vaccine engineering. GSK otilimab trial. 38 new clinical trials. Virus persistence times. Outcomes for sickle cell and cancer patients. High risk thrombosis. Olfactory dysfunction. Pneumonia vs ARDS. Adapting sacubitril/valsartan. Blood thinners. Mouse study sheds light

Australian adult consumers\u27 beliefs about plant foods: a qualitative study

This exploratory qualitative study examined consumers&rsquo; perceived barriers and benefits of plant food (fruits, vegetables, grains, legumes, nuts, seeds) consumption and views on the promotion of these foods. Ten focus groups were conducted in Melbourne, Australia. Groups consisted of employees of various workplaces, community group members, university students, and inner-city residents. Health-related benefits predominated, particularly relating to the properties of plant foods (e.g., vitamins). Taste, variety, versatility, and environmental benefits were also considered important. The main barriers to eating plant foods were lack of knowledge and skills and length of preparation time. The poor quality of plant foods was also an issue for consumers. Awareness of the promotion of plant foods was generally high. Participants noted that promotions require a stronger practical emphasis with a focus on quick, easy-to-prepare foods and meals. These findings provide insight into effective ways to promote a higher consumption of plant foods<br /

2020-04-28 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM case update. NM antibody testing. Las Cruces essential worker screening. Small business closure inequity. More jobless benefits. Santa Fe furloughs. NM Funeral homes prepared. NM oil sector hit. State-by-state restrictions/reopenings. US testing expansion. JAMA on prisons. NY reopening focus. Farmers euthanizing animals. New Zealand success. Stockholm herd immunity. UK worst-hit in Europe. Japanese island lockdown. Spain multi-phase plan. Economic damage lockdown duration. Oil price impacts. Aerosol intubation box. Family cluster transmission. US contact tracing lacking. Chinese tracing system. Early US deaths undercounted. More poison center calls. Homeless shelter infection. Reduced coronary syndrome admissions. Italian predicted model. GIS spatial modeling. Exit strategy schemes. Reopening public buildings. Preventive health screening declines. Stress prevention on return to work. Mental health consequences. Protecting healthcare worker well-being. Mental health training lacking. Hospital toilet viral hotspot. Mobile phone tracking. Creating equitable society. Prone positioning protocol. Negative-pressure tracheostomy. Glucocorticoids adrenal insufficiency. ICU team models. Healthcare worker grief. Conducting clinical trials. UK home-care testing. Dry swabbing. ACE inhibitor benefits. 90 vaccines in development. Heparin and thrombocytopenia. 53 clinical trials registered. Respirator comparison. SARS-coV-2 genetic diversity. Transmission with temperature. Antibody dynamics. Vitamin D and severity. Immunosuppression and severity. Temporal artery thermometers low sensitivity. Digestive symptoms and hospitalization