The Electron Scattering Region in Seyfert Nuclei

The electron scattering region (ESR) is one of important ingredients in Seyfert nuclei because it makes possible to observe the hidden broad line region (hereafter HBLR) in some type 2 Seyfert nuclei (hereafter S2s). However, little is known about its physical and geometrical properties. Using the number ratio of S2s with and without HBLR, we investigate statistically where the ESR is in Seyfert nuclei. Our analysis suggests that the ESR is located at radius between $\sim$ 0.01 pc and $\sim$ 0.1 pc from the central engine. We also discuss a possible origin of the ESR briefly.Comment: 5 pages and 1 figure. The Astrophysical Journal (Letters), in pres

Tunneling spectra of submicron Bi2_2Sr2_2CaCu2_2O8+δ_{8+\delta} intrinsic Josephson junctions: evolution from superconducting gap to pseudogap

Tunneling spectra of near optimally doped, submicron Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ intrinsic Josephson junctions are presented, and examined in the region where the superconducting gap evolves into pseudogap. The spectra are analyzed using a self-energy model, proposed by Norman {\it et al.}, in which both quasiparticle scattering rate $\Gamma$ and pair decay rate $\Gamma_{\Delta}$ are considered. The density of states derived from the model has the familiar Dynes' form with a simple replacement of $\Gamma$ by $\gamma_+$ = ($\Gamma$ + $\Gamma_{\Delta}$)/2. The $\gamma_+$ parameter obtained from fitting the experimental spectra shows a roughly linear temperature dependence, which puts a strong constraint on the relation between $\Gamma$ and $\Gamma_{\Delta}$. We discuss and compare the Fermi arc behavior in the pseudogap phase from the tunneling and angle-resolved photoemission spectroscopy experiments. Our results indicate an excellent agreement between the two experiments, which is in favor of the precursor pairing view of the pseudogap.Comment: 7 pages, 6 figure

Giant Molecular Outflows Powered by Protostars in L1448

We present sensitive, large-scale maps of the CO J=1-0 emission of the L1448 dark cloud. These maps were acquired using the On-The-Fly capability of the NRAO 12-meter telescope. CO outflow activity is seen in L1448 on parsec-scales for the first time. Careful comparison of the spatial and velocity distribution of our high-velocity CO maps with previously published optical and near-infrared images and spectra has led to the identification of six distinct CO outflows. We show the direct link between the heretofore unknown, giant, highly-collimated, protostellar molecular outflows and their previously discovered, distant optical manifestations. The outflows traced by our CO mapping generally reach the projected cloud boundaries. Integrated intensity maps over narrow velocity intervals indicate there is significant overlap of blue- and red-shifted gas, suggesting the outflows are highly inclined with respect to the line-of-sight, although the individual outflow position angles are significantly different. The velocity channel maps also show that the outflows dominate the CO line cores as well as the high-velocity wings. The magnitude of the combined flow momenta, as well as the combined kinetic energy of the flows, are sufficient to disperse the 50 solar mass NH3 cores in which the protostars are currently forming, although some question remains as to the exact processes involved in redirecting the directionality of the outflow momenta to effect the complete dispersal of the parent cloud.Comment: 11 pages, 9 figures, to be published in the Astronomical Journa

Disruption of Protein Kinase A in Mice Enhances Healthy Aging

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIβ, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive. It was therefore hypothesized that RIIB null (RIIβ−/−) mice would express anti-aging phenotypes. We conducted lifespan studies using 40 mutant and 40 wild type (WT) littermates of equal gender numbers and found that both the median and maximum lifespans were significantly increased in mutant males compared to WT littermates. The median lifespan was increased from 884 days to 1005 days (p = 0.006 as determined by the log rank test) and the 80% lifespan (defined here as 80% deaths) was increased from 941 days to 1073 days (p = 0.004 as determined by the Wang-Allison test). There was no difference in either median or 80% lifespan in female genotypes. WT mice of both genders became increasingly obese with age, while mutant mice maintained their lean phenotype into old age. Adiposity was found to correlate with lifespan for males only. 50% of male mice between 30 and 35 g, corresponding to about 5% body fat, for either genotype lived over 1000 days. No male mouse outside of this weight range achieved this lifespan. During their last month of life, WT mice began losing weight (a total of 8% and 15% of body weight was lost for males and females, respectively), but RIIβ−/− male mice maintained their lean body mass to end of life. This attenuation of decline was not seen in female mutant mice. Old male mutant mice were insulin sensitive throughout their life. Both genders showed modestly lower blood glucose levels in old mutants compared to WT. Male mutants were also resistant to age-induced fatty liver. Pathological assessment of tissues from end of life male mutant mice showed a decrease in tumor incidence, decreased severity of renal lesions, and a trend towards a decrease in age-related cardiac pathology. These findings help establish the highly conserved nature of PKA and suggest that disruption of PKA affects physiological mechanisms known to be associated with healthy aging

Disparities in registration and use of an online patient portal among older adults: findings from the LitCog cohort

(C) The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved.Financial disclosure: This project was supported by the National Institute on Aging (R01 AG030611), the National Center for Research Resources (5UL1RR025741), and the National Center for Advancing Translational Sciences (Grant 8UL1TR000150). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Smith is currently supported by a Cancer Research UK Fellowship

On-the-fly Uniformization of Time-Inhomogeneous Infinite Markov Population Models

This paper presents an on-the-fly uniformization technique for the analysis of time-inhomogeneous Markov population models. This technique is applicable to models with infinite state spaces and unbounded rates, which are, for instance, encountered in the realm of biochemical reaction networks. To deal with the infinite state space, we dynamically maintain a finite subset of the states where most of the probability mass is located. This approach yields an underapproximation of the original, infinite system. We present experimental results to show the applicability of our technique

How metal films de-wet substrates - identifying the kinetic pathways and energetic driving forces

We study how single-crystal chromium films of uniform thickness on W(110) substrates are converted to arrays of three-dimensional (3D) Cr islands during annealing. We use low-energy electron microscopy (LEEM) to directly observe a kinetic pathway that produces trenches that expose the wetting layer. Adjacent film steps move simultaneously uphill and downhill relative to the staircase of atomic steps on the substrate. This step motion thickens the film regions where steps advance. Where film steps retract, the film thins, eventually exposing the stable wetting layer. Since our analysis shows that thick Cr films have a lattice constant close to bulk Cr, we propose that surface and interface stress provide a possible driving force for the observed morphological instability. Atomistic simulations and analytic elastic models show that surface and interface stress can cause a dependence of film energy on thickness that leads to an instability to simultaneous thinning and thickening. We observe that de-wetting is also initiated at bunches of substrate steps in two other systems, Ag/W(110) and Ag/Ru(0001). We additionally describe how Cr films are converted into patterns of unidirectional stripes as the trenches that expose the wetting layer lengthen along the W[001] direction. Finally, we observe how 3D Cr islands form directly during film growth at elevated temperature. The Cr mesas (wedges) form as Cr film steps advance down the staircase of substrate steps, another example of the critical role that substrate steps play in 3D island formation

The Radio - X-ray relation as a star formation indicator: Results from the VLA--E-CDFS Survey

In order to trace the instantaneous star formation rate at high redshift, and hence help understanding the relation between the different emission mechanisms related to star formation, we combine the recent 4 Ms Chandra X-ray data and the deep VLA radio data in the Extended Chandra Deep Field South region. We find 268 sources detected both in the X-ray and radio band. The availability of redshifts for $\sim 95$ of the sources in our sample allows us to derive reliable luminosity estimates and the intrinsic properties from X-ray analysis for the majority of the objects. With the aim of selecting sources powered by star formation in both bands, we adopt classification criteria based on X-ray and radio data, exploiting the X-ray spectral features and time variability, taking advantage of observations scattered across more than ten years. We identify 43 objects consistent with being powered by star formation. We also add another 111 and 70 star forming candidates detected only in the radio or X-ray band, respectively. We find a clear linear correlation between radio and X-ray luminosity in star forming galaxies over three orders of magnitude and up to $z \sim 1.5$. We also measure a significant scatter of the order of 0.4 dex, higher than that observed at low redshift, implying an intrinsic scatter component. The correlation is consistent with that measured locally, and no evolution with redshift is observed. Using a locally calibrated relation between the SFR and the radio luminosity, we investigate the L_X(2-10keV)-SFR relation at high redshift. The comparison of the star formation rate measured in our sample with some theoretical models for the Milky Way and M31, two typical spiral galaxies, indicates that, with current data, we can trace typical spirals only at z<0.2, and strong starburst galaxies with star-formation rates as high as $\sim 100 M_\odot yr^{-1}$, up to $z\sim 1.5$.Comment: 21 pages, 10 figures, 5 table