1,622 research outputs found
Frequency and duration of low-wind-power events in Germany
In the transition to a renewable energy system, the occurrence of
low-wind-power events receives increasing attention. We analyze the frequency
and duration of such events for onshore wind power in Germany, based on 40
years of reanalysis data and open software. We find that low-wind-power events
are less frequent in winter than in summer, but the maximum duration is
distributed more evenly between months. While short events are frequent, very
long events are much rarer. Every year, a period of around five consecutive
days with an average wind capacity factor below 10% occurs, and every ten years
a respective period of nearly eight days. These durations decrease if only
winter months are considered. The longest event in the data lasts nearly ten
days. We conclude that public concerns about low-wind-power events in winter
may be overrated, but recommend that modeling studies consider multiple weather
years to properly account for such events.Comment: This is an update version after peer revie
Meeresspiegelschwankungen und ihre geologische Ãœberlieferung im Karbonatsystem
The dependency between carbonate sediment production on a carbonate platform and its relation to sea-level changes is discusses here. The topography of the upper slope plays an important role in determining the way in which sedimentation continues during lowstands in sea level. The mineralogy and composition of sediments produced on the platform can clearly be related to those found in sediments deposited in the adjacent basin. Two examples from the Recent are described: (1) Sanganeb Atoll (Red Sea), and (2) Pedro Bank (caribbean). The applicability of the "highstand shedding" principle is shown for ancient carbonate platforms
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Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway
Purpose Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotection in vivo against ischemia-reperfusion injury (IRI)-induced apoptosis of retinal ganglion cells (RGC) and in vitro of neuronal SH-SY5Y-cells via activation of soluble guanylate-cyclase (sGC). Methods: To mimic ischemic respiratory arrest, SH-SY5Y-cells were incubated with rotenone (100 nmol/L, 4 h) ± CORM ALF186 (10–100 µmol/L) or inactivated ALF186 lacking the potential of releasing CO. Apoptosis and reactive oxygen species (ROS) production were analyzed using flow-cytometry (Annexin V, mitochondrial membrane potential, CM-H2DCFDA) and Western blot (Caspase-3). The impact of ALF186± respiratory arrest on cell signaling was assessed by measuring expression of nitric oxide synthase (NOS) and soluble guanylate-cyclase (sGC) and by analyzing cellular cGMP levels. The effect of ALF186 (10 mg/kg iv) on retinal IRI in Sprague-Dawley rats was assessed by measuring densities of fluorogold-labeled RGC after IRI and by analysis of apoptosis-related genes in retinal tissue. Results: ALF186 but not inactivated ALF186 inhibited rotenone-induced apoptosis (Annexin V positive cells: 25±2% rotenone vs. 14±1% ALF186+rotenone, p<0.001; relative mitochondrial membrane potential: 17±4% rotenone vs. 55±3% ALF186+rotenone, p<0.05). ALF186 increased cellular cGMP levels (33±5 nmol/L vs. 23±3 nmol/L; p<0.05) and sGC expression. sGC-inhibition attenuated ALF186-mediated protection (relative mitochondrial membrane potential: 55±3% ALF186+rotenone vs. 20±1% ODQ+ALF186+rotenone, p<0.05). ALF186 protected RGC in vivo (IRI 1255±327 RGC/mm2 vs. ALF186+IRI 2036±83; p<0.05) while sGC inhibition abolished the protective effects of ALF186 (ALF186+IRI 2036±83 RGC/mm2 vs. NS-2028+ALF186+IRI 1263±170, p<0.05). Conclusions: The CORM ALF186 inhibits IRI-induced neuronal cell death via activation of sGC and may be a useful treatment option for acute ischemic insults to the retina and the brain
Reduction in wound healing complications and infection rate by lumbar CSF drainage after decompressive hemicraniectomy
Objective: Wound healing disorders and surgical site infections are the most frequently encountered complications after decompressive hemicraniectomy (DHC). Subgaleal CSF accumulation causes additional tension of the scalp flap and increases the risk of wound dehiscence, CSF fistula, and infection. Lumbar CSF drainage might relieve subgaleal CSF accumulation and is often used when a CSF fistula through the surgical wound appears. The aim of this study was to investigate if early prophylactic lumbar drainage might reduce the rate of postoperative wound revisions and infections after DHC.
Methods: The authors retrospectively analyzed 104 consecutive patients who underwent DHC from January 2019 to May 2021. Before January 2020, patients did not receive lumbar drainage, whereas after January 2020, patients received lumbar drainage within 3 days after DHC for a median total of 4 (IQR 2-5) days if the first postoperative CT scan confirmed open basal cisterns. The primary endpoint was the rate of severe wound healing complications requiring surgical revision. Secondary endpoints were the rate of subgaleal CSF accumulations and hygromas as well as the rate of purulent wound infections and subdural empyema.
Results: A total of 31 patients died during the acute phase; 34 patients with and 39 patients without lumbar drainage were included for the analysis of endpoints. The predominant underlying pathology was malignant hemispheric stroke (58.8% vs 66.7%) followed by traumatic brain injury (20.6% vs 23.1%). The rate of surgical wound revisions was significantly lower in the lumbar drainage group (5 [14.7%] vs 14 [35.9%], p = 0.04). A stepwise linear regression analysis was used to identify potential covariates associated with wound healing disorder and reduced them to lumbar drainage and BMI. One patient was subject to paradoxical herniation. However, the patient's symptoms rapidly resolved after lumbar drainage was discontinued, and he survived with only moderate deficits related to the primary disease. There was no significant difference in the rate of radiological herniation signs. The median lengths of stay in the ICU were similar, with 12 (IQR 9-23) days in the drainage group compared with 13 (IQR 11-23) days in the control group (p = 0.21).
Conclusions: In patients after DHC and open basal cisterns on postoperative CT, lumbar drainage appears to be safe and reduces the rate of surgical wound revisions and intracranial infection after DHC while the risk for provoking paradoxical herniation is low early after surgery
Amorphous Molecular Materials for Directed Supercontinuum Generation
Molecular compounds of the general formula [(RT)4E6] (R=organic or organometallic substituent; T=C, Si, Ge, Sn; E=CH2, S, Se), hence adamantane derivatives and inorganic-organic hybrid compounds based on a heteroadamantane structure exhibit a non-linear optical response upon radiation with a continuous-wave near-infrared laser. The effect depends on the compounds’ habitus, which itself depends on the elemental composition of the cluster core, and on the nature of the organic substituents. A combination of these parameters that cause the material to be intrinsically amorphous leads to supercontinuum generation and thus to the emission of a broad spectrum, potentially appearing as white light. Notably, the emission essentially retains the driving laser\u27s directionality. For crystalline samples, second harmonic generation is observed instead, which points to a close relationship of the optical properties and the intermolecular order. Variation of R, T, and E allows further fine-tuning of the emitted spectra. We present all studies made in regards to these effects and our overarching conclusions derived from them
To what extent can a sediment yield model be trusted? A case study from the passaúna catchment, brazil
Soil degradation and reservoir siltation are two of the major actual environmental, scientific, and engineering challenges. With the actual trend of world population increase, further pressure is expected on both water and soil systems around the world. Soil degradation and reservoir siltation are, however, strongly interlinked with the erosion processes that take place in the hydrological catchments, as both are consequences of these processes. Due to the spatial scale and duration of erosion events, the installation and operation of monitoring systems are rather cost- and time-consuming. Modeling is a feasible alternative for assessing the soil loss adequately. In this study, the possibility of adopting reservoir sediment stock as a validation measure for a monthly time-step sediment input model was investigated. For the assessment of sediment stock in the reservoir, the commercial free-fall penetrometer GraviProbe (GP) was used, while the calculation of sediment yield was calculated by combining a revised universal soil loss equation (RUSLE)-based model with a sediment delivery ratio model based on the connectivity approach. For the RUSLE factors, a combination of remote sensing, literature review, and conventional sampling was used. For calculation of the C Factor, satellite imagery from the Sentinel-2 platform was used. The C Factor was derived from an empirical approach by combining the normalized difference vegetation index (NDVI), the degree of soil sealing, and land-use/land-cover data. The key research objective of this study was to examine to what extent a reservoir can be used to validate a long-term erosion model, and to find out the limiting factors in this regard. Another focus was to assess the potential improvements in erosion modeling from the use of Sentinel-2 data. The use of such data showed good potential to improve the overall spatial and temporal performance of the model and also dictated further opportunities for using such types of model as reliable decision support systems for sustainable catchment management and reservoir protection measures
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