Controversies in dermatology: Part V.

“It were not best that we should all think alike; it is difference of opinion that makes horse-races” Mark Twain (Samuel L. Clemens) in The Tragedy of Pudd’nead Wilson, Ch. 19, “Pudd’nead Wilson’s Calendar”. Part V of Controversies in Dermatology continues the precedent of earlier issues by providing a platform for discussion of a broad range of contemporary and controversial issues. In this issue of Clinics in Dermatology, we will forego the temptation to expose hidden agendas and witches brews, rather, we shall focus on accepted beliefs, principles, doctrines, and paradigms, which you may find even more astonishing

Barrier-repair prescription moisturizers: Do we really need them? Facts and controversies.

There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events ending up in inflammation

Combining Sentiment Lexica with a Multi-View Variational Autoencoder

When assigning quantitative labels to a dataset, different methodologies may rely on different scales. In particular, when assigning polarities to words in a sentiment lexicon, annotators may use binary, categorical, or continuous labels. Naturally, it is of interest to unify these labels from disparate scales to both achieve maximal coverage over words and to create a single, more robust sentiment lexicon while retaining scale coherence. We introduce a generative model of sentiment lexica to combine disparate scales into a common latent representation. We realize this model with a novel multi-view variational autoencoder (VAE), called SentiVAE. We evaluate our approach via a downstream text classification task involving nine English-Language sentiment analysis datasets; our representation outperforms six individual sentiment lexica, as well as a straightforward combination thereof.Comment: To appear in NAACL-HLT 201

How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections?

Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that determine the dynamics of viral load within the human host, can inform investigators on the course and severity of infection and the efficacy of a novel treatment. We estimated the values of key infection-related quantities that determine the course of natural infection from viral load data, using Markov Chain Monte Carlo methods. The data were placebo group viral load measurements collected during volunteer challenge studies, conducted by Roche, as part of the oseltamivir trials. We calculated the values of the quantities for each patient and the correlations between the quantities, symptom severity and body temperature. The greatest variation among individuals occurred in the viral load peak and area under the viral load curve. Total symptom severity correlated positively with the basic reproductive number. The most sensitive endpoint for therapeutic trials with the goal to cure patients is the duration of infection. We suggest laboratory experiments to obtain more precise estimates of virological quantities that can supplement clinical endpoint measurements

Computational Study on the Co-Mediated Intramolecular Pauson-Khand Reaction of Fluorinated and Chiral N-Tethered 1,7-Enynes

The Co2(CO)8-mediated intramolecular Pauson−Khand reaction is an elegant approach to obtain cyclopentenone derivatives containing asymmetric centers. In this work, we employed density functional theory calculations at the M11/6-311+G(d,p) level of theory to investigate the mechanism and reactivity for the Pauson−Khand reaction of fluorinated and asymmetric N-tethered 1,7-enynes. The rate determining step was found to be the intramolecular alkene insertion into the carbon−cobalt bond. The stereoselectivity of the alkene insertion step was rationalized by the different transition states showing the coordination of the alkene through the Re- and Si-face. The effects of different fluorine groups and steric effects on both the alkenyl and alkynyl moieties were also theoretically investigated

Applied Dynamics In School And Practice

Mechanical engineering, mechanical engineering technology, and related educational programs are not addressing in a sufficient way the principles associated with applying analytical investigations in solving actual engineering problems. Because of this, graduates do not have the adequate skills required to use the methods of applied dynamics in the process of analyzing mechanical systems. These methods allow one to obtain an understanding of the role of the parameters of a system and to carry out a purposeful control of the values of these parameters with the goal to achieve the desired performance. Engineering and engineering technology programs pay very little attention to addressing these steps. It should be stressed that these programs do not offer a universal straightforward methodology of solving linear differential equations of motion that allow revealing all important interrelationships between the aspects of the engineering problem. It is difficult to formulate the reasons why there is such a low interest in applying the analytical approach in order to reveal the interrelationships between decisive aspects of the operational process of an engineering system in order to achieve the desired goal. Actually, there is almost a complete silence with regard to this issue. Hence, we assume that the first reason could be that there is no recognition of the existence of such a problem. In other words, there is no need to apply these analytical methods since these methods are not beneficial. We do not believe that the engineering community supports this reason. It is not a matter of demonstrating factual data that show how many times the theory was helpful. Without the support of the theory we cannot justifiably evaluate the results of our solutions. If we agree that there is problem, then why are there no publications that would stimulate discussions leading toward a solution of the problem? Here is the second reason. Until now, engineering programs do not present the straightforward universal theoretically sound methodologies for solving the second order linear differential equations that are vital for mechanical and electrical engineering. Without any suggestions of how to solve this problem, it did not make much sense to begin a discussion. In our opinion, this is why we have silence with the regard to this problem. However, it is well known that Laplace Transforms allow solving any linear differential equation of motion. It is justifiable to assume that the main reason why the Laplace Transform methodology is not adopted by learning environments consists in the absence of the majority of tables of Laplace Transform Pairs that are needed for solving differential equations of motion as well as differential equations describing electrical circuits. However, the situation is changed. Current publications comprise the adequate tables that are needed for solving linear differential equations of motion associated with all common mechanical engineering problems. Practicing engineers and students need assistance in acquiring the knowledge of composing differential equations of motion. They need certain training in solving these equations using Laplace Transform methodology. Several recommendations are proposed on how to expedite the implementation in academia and in industry of the methods of applied dynamics in solving common mechanical engineering problems