Best-Fit Ellipsoids of Atom-Probe Tomographic Data to Study Coalescence of Gamma Prime (L1_2) Precipitates in Ni-Al-Cr

An algorithm is presented to fit precipitates in atom probe tomographic data sets as equivalent ellipsoids. Unlike previous techniques, which measure only the radius of gyration, these ellipsoids retain the moments of inertia and principle axes of the original precipitate, preserving crystallographic orientational information. The algorithm is applied to study interconnected gamma prime precipitates (L1_2) in the Gamma-matrix (FCC) of a Ni-Al-Cr alloy. The precipitates are found to coagulate along -type directions.Comment: Accepted for publication in Scripta Materialia, added information about local magnification effect

Partnerships in a Global Mental Health Research Programme-the Example of PRIME.

Collaborative research partnerships are necessary to answer key questions in global mental health, to share expertise, access funding and influence policy. However, partnerships between low- and middle-income countries (LMIC) and high-income countries have often been inequitable with the provision of technical knowledge flowing unilaterally from high to lower income countries. We present the experience of the Programme for Improving Mental Health Care (PRIME), a LMIC-led partnership which provides research evidence for the development, implementation and scaling up of integrated district mental healthcare plans in Ethiopia, India, Nepal, South Africa and Uganda. We use Tuckman's first four stages of forming, storming, norming and performing to reflect on the history, formation and challenges of the PRIME Consortium. We show how this resulted in successful partnerships in relation to management, research, research uptake and capacity building and reflect on the key lessons for future partnerships

Grain Boundary Segregation in Silver-Nickel and Copper-Bismuth Alloys

Gegenstand dieser Arbeit ist die Charakterisierung der Korngrenzsegregation in Ag-Ni und Cu-Bi Legierungen mit Hilfe der tomographischen Atomsonde (TAP) und weiterer hochauflösender Methoden. Nanokristalline Ag-Ni- sowie Cu-Bi-Schichten wurden durch Ar-Ionen-Sputtern als Ag-Ni-Multilagen und als Cu-Bi-Legierung mit einer starken Bi-Übersättigung auf Wolfram-Substratspitzen deponiert. Zusätzlich wurden nanokristalline inertgas-kondensierte Ag-Ni Proben mit verschiedenen Ni-Gehalten hergestellt. Es gelang mit einer im Rahmen dieser Arbeit neu entwickelten Präparationsmethode erstmalig, eine Atomsonden-Untersuchung der Korngrenzsegregation an gezielt mit einigen 10 ppm Bi-dotierten Cu-Bikristallen durchzuführen.Entgegen bestehender theoretischer Annahmen wurde für Ag-Ni Legierungen weder in Multilagen noch in den nanokristallinen Proben eine Segregation von Ni an Ag-Korngrenzen festgestellt. Im Zuge von Wärmebehandlungen wird die Rekristallisation der Ag-Körner zunächst durch fein verteilte Ni-Körner behindert. Dies führt zu einer Auswölbung gepinnter Ag-Korngrenzen, welche durch einen modifizierten Orowan-Mechanismus erklärt werden kann. Schließlich vergröbern die Ni-Körner, die zur Minimierung der Verzerrungsenergie eine plattenförmige Gestalt annehmen.In den sputter-deponierten Cu-Bi-Legierungsschichten findet sich schon im Ausgangszustand eine deutliche Bi-Segregation an den Cu-Korngrenzen. Der gefundene Exzess konnte quantitativ auf ein Modell zurückgeführt werden, in dem sich Bi-Atome aufgrund ihrer Größe bevorzugt im Dilatationsfeld von Versetzungen anreichern. Thermische Behandlungen führen durch eine weitere Bi-Segregation zu eine katastrophalen Versprödung dieser Schichten. Untersuchungen der Gleichgewichts-Segregation bei 850°C an bikristallinen Proben mit einer kristallographisch wohl definierten Sigma 19a {331} Korngrenze ermöglichten eine Bestimmung der Segregationsenthalpie sowie der Absenkung der spezifischen Korngrenzenergie

Child labour in Addis Ketema, Ethiopia : a study in mental health

Background: Child labour is a very common global problem. There are an estimated over 250 million in the world, and about 7.5 million child labourers in Ethiopia. Most of the studies available to date focus on the social, political, and economical issues, but very little on mental health or psychosocial problems of child labourers. There is no study describing the epidemiology of psychiatric disorders among this group of children. Aims: 1. to assess the level of awareness and attitude of an urban community on child labour. 2. to describe the patterns of child labour and the experiences of child labourers in the informal sector with emphasis to child domestic labour. 3. to determine the risk factors contributing to child abuse and psychiatric disorders in child labourers. Method: An initial qualitative survey, using key informants in a Rapid Assessment Procedure, was conducted in a central urban area of Addis Ababa, to determine the knowledge, attitude, and intervention priorities of the people on child labour. A cross-sectional quantitative study informed by this initial survey was conducted in a sampled population of 5-15 year old child labourers and non-economically active controls. Information about possible risk factors, socio-demography and child abuse were gathered using a questionnaire different from that used for mental health assessment. An Amharic translation of the Diagnostic Interview for Children and Adolescents (DICA) was used to collect data for symptoms of mental disorders and diagnosis was made according to the American Psychiatric Association (APA) Diagnostic and Statistical Manual, 3rd edition (DSM-III-R) criteria. Data analysis was done using Statistical Package for Social Sciences (SPSS) software. Results: Domestic labour, working in the streets, and in private enterprises were the three main types of child labour identified. These types of child labour were identified by 82% (n=158) key informants, who thought child labour was a social problem, mainly resulting from poverty, and associated with abuse. In the quantitative study (5-15 year old sample) 528 child labourers and 472 non-labourers were included in the study. Of the child labourers, 34% were engaged in domestic labour, 57% working in the streets, and 9% in private enterprises. Over half of the child labourers worked for more than 9 hours daily. The prevalence of child abuse was 43.9% and 17.2% among child labourers and controls, respectively (OR=3.7, 95% CI: 2.74, 5.09; p<0.001). Emotional abuse was the commonly encountered abuse compared to other types (OR=3.06, 95% CI: 2.23-4.20; p< 0.001). Child domestics and street labourers were the most vulnerable group. The prevalence of any DSM-III-R psychiatric disorder was 20.1% and 12.5% among child labourers and controls, respectively and the difference was statistically significant (OR=1.89, 95% CI: 1.34-2.67, p<0.01). Controlling for all socio-demographic factors, child labour status was the only significant factor in determining DSM-III-R diagnosis. Discussion: In a comparable group of child labourers and controls, child labourers were found to be a high-risk group for different types of abuse and psychiatric disorders. Although parental unemployment and low maternal education were associated with child labour, the only factor that was associated with psychiatric morbidity was being a child labourer. It seems that poverty is not the only reason for child labour; hence its mere alleviation alone is unlikely to dramatically improve the risk for child labour and mental health of the children. There are many motivating reasons to be a child labourer, and likewise various positive and negative maintaining factors. Therefore, not all child labourers are prepared to stop their paid job altogether in order to become a full time student. Recommendation: Education of all children and parents is a keystone to prevent child labour and the associated consequences. In enforcing legislations on child labour, the government, non-governmental organisation (NGO), and the public should view child labour as a menace in children’s development, with risk of psychiatric disorders. Policy design should accommodate the interests of children. It is recommended to do a cohort and a larger size study, in order to further examine the association of various risk factors, and psychiatric disorders in a comparative and similar vulnerable group of children

Child labour in Addis Ketema, Ethiopia : a study in mental health

Background: Child labour is a very common global problem. There are an estimated over 250 million in the world, and about 7.5 million child labourers in Ethiopia. Most of the studies available to date focus on the social, political, and economical issues, but very little on mental health or psychosocial problems of child labourers. There is no study describing the epidemiology of psychiatric disorders among this group of children. Aims: 1. to assess the level of awareness and attitude of an urban community on child labour. 2. to describe the patterns of child labour and the experiences of child labourers in the informal sector with emphasis to child domestic labour. 3. to determine the risk factors contributing to child abuse and psychiatric disorders in child labourers. Method: An initial qualitative survey, using key informants in a Rapid Assessment Procedure, was conducted in a central urban area of Addis Ababa, to determine the knowledge, attitude, and intervention priorities of the people on child labour. A cross-sectional quantitative study informed by this initial survey was conducted in a sampled population of 5-15 year old child labourers and non-economically active controls. Information about possible risk factors, socio-demography and child abuse were gathered using a questionnaire different from that used for mental health assessment. An Amharic translation of the Diagnostic Interview for Children and Adolescents (DICA) was used to collect data for symptoms of mental disorders and diagnosis was made according to the American Psychiatric Association (APA) Diagnostic and Statistical Manual, 3rd edition (DSM-III-R) criteria. Data analysis was done using Statistical Package for Social Sciences (SPSS) software. Results: Domestic labour, working in the streets, and in private enterprises were the three main types of child labour identified. These types of child labour were identified by 82% (n=158) key informants, who thought child labour was a social problem, mainly resulting from poverty, and associated with abuse. In the quantitative study (5-15 year old sample) 528 child labourers and 472 non-labourers were included in the study. Of the child labourers, 34% were engaged in domestic labour, 57% working in the streets, and 9% in private enterprises. Over half of the child labourers worked for more than 9 hours daily. The prevalence of child abuse was 43.9% and 17.2% among child labourers and controls, respectively (OR=3.7, 95% CI: 2.74, 5.09; p<0.001). Emotional abuse was the commonly encountered abuse compared to other types (OR=3.06, 95% CI: 2.23-4.20; p< 0.001). Child domestics and street labourers were the most vulnerable group. The prevalence of any DSM-III-R psychiatric disorder was 20.1% and 12.5% among child labourers and controls, respectively and the difference was statistically significant (OR=1.89, 95% CI: 1.34-2.67, p<0.01). Controlling for all socio-demographic factors, child labour status was the only significant factor in determining DSM-III-R diagnosis. Discussion: In a comparable group of child labourers and controls, child labourers were found to be a high-risk group for different types of abuse and psychiatric disorders. Although parental unemployment and low maternal education were associated with child labour, the only factor that was associated with psychiatric morbidity was being a child labourer. It seems that poverty is not the only reason for child labour; hence its mere alleviation alone is unlikely to dramatically improve the risk for child labour and mental health of the children. There are many motivating reasons to be a child labourer, and likewise various positive and negative maintaining factors. Therefore, not all child labourers are prepared to stop their paid job altogether in order to become a full time student. Recommendation: Education of all children and parents is a keystone to prevent child labour and the associated consequences. In enforcing legislations on child labour, the government, non-governmental organisation (NGO), and the public should view child labour as a menace in children’s development, with risk of psychiatric disorders. Policy design should accommodate the interests of children. It is recommended to do a cohort and a larger size study, in order to further examine the association of various risk factors, and psychiatric disorders in a comparative and similar vulnerable group of children

Barriers to and Factors Facilitating Adherence to Antiretroviral Therapy from the Perspectives of Patients in Maqala City, T3gray Region, Ethiopia

The decentralization and free provision of life-saving antiretroviral therapy (ART) to health centers in Ethiopia began in 2006. In the T~gray Region, the number of people who began ART increased almost tenfold between 2006 and 2010, yet treatment retention among these patients has been challenging. This qualitative analysis explores the experiences of patients who either continued or interrupted adherence to ART. Conducted at three health facilities in Maqala City from August to October 2009, the aim of this study was to document the facilitating factors and barriers to ART adherence from patients\u27 perspectives.For both continued and interrupted adherence, the most common facilitating factors are a beliefin the efficacy of the medication, trust in the health-care providers, low level of side effects, positive treatment results, and having an HIV-positive friend. Each restarter had distinctive reasons for interrupting the ART. Major contributing factors to ART interruption were the side effects and fear of stigma or discrimination.In urban neighborhoods with a high volume of rural migration, where people lived far from their extended families, ART patients were more dependent on health workers for adherence support