Quasar Black Hole Masses from Velocity Dispersions

Much progress has been made in measuring black hole (BH) masses in (non-active) galactic nuclei using the tight correlation between stellar velocity dispersions (sigma) in galaxies and the mass of their central BH. The use of this correlation in quasars, however, is hampered by the difficulty in measuring sigma in host galaxies that tend to be overpowered by their bright nuclei. We discuss results from a project that focuses on z~0.3 quasars suffering from heavy extinction at shorter wavelengths. This makes it possible to obtain clean spectra of the hosts in the spectral regions of interest, while broad lines (like H-alpha) are still visible at longer wavelengths. We compare BH masses obtained from velocity dispersions to those obtained from the broad line region and thus probe the evolution of this relation and BH growth with redshift and luminosity. Our preliminary results show an offset between the position of our objects and the local relation, in the sense that red quasars have, on average, lower velocity dispersions than local galaxies. We discuss possible biases and systematic errors that may affect our results.Comment: 4 pages, to appear in the proceedings of the 2nd Kolkata conference on Observational Evidence for Black Holes in the Universe, ed. S. Chakrabarti (AIP

New Equity Performance Following Chapter 11 Emergence

This body of research investigates how the performance of exchange-traded common equity from firms in Chapter 11 bankruptcy emergence compares with common stock from non-bankrupt competitors and recently public peers in short and long-term time horizons.  Return data are gathered for a sample of sixteen financially restructured companies, each paired with two non-distressed industry competitors and one recently-public peer.  Using the Capital Asset Pricing Model as a primary analytical tool, empirical tests show a positive correlation in equity returns among the samples of restructured and non-distressed market competitors and a stock underperformance from the sample of IPO competitors.  These results suggest that markets are better at judging the value of post-Chapter 11 companies relative to newly public companies and refute the theory of IPO price momentum

Predicting poverty trends by survey-to-survey imputation: The challenge of comparability

Poverty in low-income countries is usually measured using large and infrequent household consumption surveys. The challenge is to find methods to measure poverty rates more frequently. This study validates a survey-to-survey imputation method, based on a statistical model utilizing consumption surveys and light surveys to measure changes in poverty rates over time. A decade of poverty predictions and regular poverty estimates in Malawi provides a unique case study. The analysis suggests that this modelling approach works within the same context given that households’ demographic composition is included in the model. Predicting poverty using different surveys is challenging because of different aspects of comparability. A new way to account for seasonal coverage strengthens the model when imputing for surveys covering different seasons. It is important for national statistics offices and supporting agencies to prioritize maintaining consistency in the way data are collected in surveys to provide comparable trends over time.publishedVersio

Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease

We agree with Brunet and Doolittle (1) on the utility of distinguishing the evolutionarily selected effects (SE) of some genomic elements from the causal roles (CR) of other elements that lack signatures of selection (1⇓⇓–4). DNA sequences identified by biochemical approaches include both SE and CR elements, and genetic variation in both has been implicated in human traits and disease susceptibility. We thus view the Encyclopedia of DNA Elements (ENCODE) catalog and similar data resources as important foundations for understanding the DNA elements and molecular mechanisms underlying human biology and disease

Antioxidant activity in commonly grown and consumed vegetables: a screening survey

A diet rich in fruits and vegetables is associated with a reduced risk of developing cardiovascular diseases and certain types of cancer. This positive effect is related to bioactive phytochemicals found in plants.The vegetables were grown in the field or in greenhouses at the Norwegian University of Life Sciences (59º40’N) during the years 2000-2002. The vegetables were harvested at commercial maturity and analysed for dry matter and antioxidant activity assessed by the FRAP (Ferric Reducing Ability of Plasma) assay. There was a large variation in antioxidant activity both between and within different species. The highest antioxidant activity was observed in kale, red cultivars of cabbage and table beet. The lowest antioxidant activity was observed in lettuce, cucumber, carrots and tomato. The vegetables possessing a red colour showed higher antioxidant activity with the exception of carrots and tomatoes

Defining functional DNA elements in the human genome

With the completion of the human genome sequence, attention turned to identifying and annotating its functional DNA elements. As a complement to genetic and comparative genomics approaches, the Encyclopedia of DNA Elements Project was launched to contribute maps of RNA transcripts, transcriptional regulator binding sites, and chromatin states in many cell types. The resulting genome-wide data reveal sites of biochemical activity with high positional resolution and cell type specificity that facilitate studies of gene regulation and interpretation of noncoding variants associated with human disease. However, the biochemically active regions cover a much larger fraction of the genome than do evolutionarily conserved regions, raising the question of whether nonconserved but biochemically active regions are truly functional. Here, we review the strengths and limitations of biochemical, evolutionary, and genetic approaches for defining functional DNA segments, potential sources for the observed differences in estimated genomic coverage, and the biological implications of these discrepancies. We also analyze the relationship between signal intensity, genomic coverage, and evolutionary conservation. Our results reinforce the principle that each approach provides complementary information and that we need to use combinations of all three to elucidate genome function in human biology and disease

An approach towards rapid optical measurements of antioxidant activity in blueberry cultivars

Blueberries are well known for their high antioxidant levels. Compared to bilberries (V. myrtillus) with higher antioxidant activity and more intensive blue colour throughout the whole berry, highbush blueberries have the blue pigments concentrated in the skin. Highbush blueberry skin is found to contain a very high content of phenolic compounds. To measure the total antioxidant activity in blueberries, several methods, mostly destructive, including the FRAP assay, have been used. This work is an initial approach towards a simple and rapid method, combining optical and antioxidant activity measurements. Highbush blueberry (V. corymbosum) cultivars ‘Bluecrop’, ‘Hardyblue’, ‘Patriot’, and lowbush cultivars ‘Putte’ (a hybrid originated from V. angustifolium) and ‘Aron’ (V. corymbosum x V. uliginosum) were grown at the Norwegian University of Life Sciences (59º 40’N). Berries were harvested at commercial blue-ripe stage of maturity. Fresh berries were cut horizontally and placed on a scanner in order to examine berry size and skin thickness. Berries were weighed, and analysed for antioxidant activity using the FRAP (Ferric Reducing Ability of Plasma) assay. The FRAP assay is a non-specific method based on absorption changes following a reduction of a ferric- to a ferrous-complex in the presence of antioxidants.Own previous results have shown that antioxidant activity and berry weight varied between cultivars (REMBERG et al., 2003). Small berries had higher antioxidant activity compared to larger berries. In this follow-up project, skin thickness and berry diameter were measured by using an image- processing program. Berry and skin cross-section areas were correlated with the antioxidant activity

Genome-Wide Analysis Reveals Coating of the Mitochondrial Genome by TFAM

Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication and transcription. The transcription factor TFAM is critical for initiation of transcription and replication of the genome, and is also thought to perform a packaging function. Although specific binding sites required for initiation of transcription have been identified in the D-loop, little is known about the characteristics of TFAM binding in its nonspecific packaging state. In addition, it is unclear whether TFAM also plays a role in the regulation of nuclear gene expression. Here we investigate these questions by using ChIP-seq to directly localize TFAM binding to DNA in human cells. Our results demonstrate that TFAM uniformly coats the whole mitochondrial genome, with no evidence of robust TFAM binding to the nuclear genome. Our study represents the first high-resolution assessment of TFAM binding on a genome-wide scale in human cells

XMM-Newton Surveys of the Canada-France Redshift Survey Fields - III: The Environments of X-ray Selected AGN at 0.4<z<0.6

The environmental properties of a sample of 31 hard X-ray selected AGN are investigated, from scales of 500 kpc down to 30 kpc, and are compared to a control sample of inactive galaxies. The AGN all lie in the redshift range 0.4<z<0.6. The accretion luminosity-density of the Universe peaks close to this redshift range, and the AGN in the sample have X-ray luminosities close to the knee in the hard X-ray luminosity function, making them representative of the population which dominated this important phase of energy conversion. Using both the spatial clustering amplitude and near neighbour counts it is found that the AGN have environments that are indistinguishable from normal, inactive galaxies over the same redshift range and with similar optical properties. Typically, the environments are of sub-cluster richness, in contrast to similar studies of high-z quasars, which are often found in clusters with comparable richness to the Abell R>=0 clusters. It is suggested that minor mergers with low mass companions is a likely candidate for the mechanism by which these modest luminosity AGN are fuelled.Comment: 12 pages, 6 figures, accepted by MNRA