1,836 research outputs found

    Secrecy and Transparency in Nonprofit Organizations: If a Nonprofit Prefers Secrecy, What Does it Want to Hide?

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    In this paper, the authors explore the resistance of many--especially large--nonprofit organizations to the practice of transparency. We argue that this resistance reflects the stubborn attitude of elitists who usually govern the nonprofits that ordinary individuals need no more rights and information than the elite class cares to offer them. Organizational leaders withhold comprehensible information about the nonprofits’ finances and records of the boards’ policy deliberations. Suppression of such information denies prospective donors the knowledge that would allow them to make optimal decisions about where to invest their charitable donations. The authors present a summary of 85 Georgia charities to identify independent variables that are related to the charities’ willingness to publicize minutes of their board meetings. Only one independent variable has a statistically significant relationship with the willingness to publicize minutes: That is the availability of audited financial statements on the website. It is difficult to justify donors’ submission of donations to charities that are less than generous in sharing with the public honest information about their operations

    Survey of bacterial diversity in chronic wounds using Pyrosequencing, DGGE, and full ribosome shotgun sequencing

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    <p>Abstract</p> <p>Background</p> <p>Chronic wound pathogenic biofilms are host-pathogen environments that colonize and exist as a cohabitation of many bacterial species. These bacterial populations cooperate to promote their own survival and the chronic nature of the infection. Few studies have performed extensive surveys of the bacterial populations that occur within different types of chronic wound biofilms. The use of 3 separate16S-based molecular amplifications followed by pyrosequencing, shotgun Sanger sequencing, and denaturing gradient gel electrophoresis were utilized to survey the major populations of bacteria that occur in the pathogenic biofilms of three types of chronic wound types: diabetic foot ulcers (D), venous leg ulcers (V), and pressure ulcers (P).</p> <p>Results</p> <p>There are specific major populations of bacteria that were evident in the biofilms of all chronic wound types, including <it>Staphylococcus, Pseudomonas, Peptoniphilus, Enterobacter, Stenotrophomonas, Finegoldia</it>, and <it>Serratia </it>spp. Each of the wound types reveals marked differences in bacterial populations, such as pressure ulcers in which 62% of the populations were identified as obligate anaerobes. There were also populations of bacteria that were identified but not recognized as wound pathogens, such as <it>Abiotrophia para-adiacens </it>and <it>Rhodopseudomonas </it>spp. Results of molecular analyses were also compared to those obtained using traditional culture-based diagnostics. Only in one wound type did culture methods correctly identify the primary bacterial population indicating the need for improved diagnostic methods.</p> <p>Conclusion</p> <p>If clinicians can gain a better understanding of the wound's microbiota, it will give them a greater understanding of the wound's ecology and will allow them to better manage healing of the wound improving the prognosis of patients. This research highlights the necessity to begin evaluating, studying, and treating chronic wound pathogenic biofilms as multi-species entities in order to improve the outcomes of patients. This survey will also foster the pioneering and development of new molecular diagnostic tools, which can be used to identify the community compositions of chronic wound pathogenic biofilms and other medical biofilm infections.</p

    Fundamentals of Flakeboard Manufacture: Viscoelastic Behavior of the Wood Component

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    Theories of the viscoelastic behavior of amorphous polymers are reviewed and are used to describe the density gradient formation in flakeboard. This technique utilizes measured temperature and gas pressure at discrete locations inside a flake mat during hot pressing to predict the glass transition temperature of wood as a function of press time. The difference between the flake temperature and the predicted glass transition temperature is a relative indicator of the amount of flake deformation and stress relaxation at a location in the mat. A knowledge of the stress history imposed in the mat is then used to relate flake deformation and stress relaxation to the formation of a density gradient. This analysis allows for a significant portion of the density gradient to develop after the hot press has closed. Experimental data for various density gradients support the theories presented here

    Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and Titanium amplicon pyrosequencing and metagenomic approaches

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    <p>Abstract</p> <p>Background</p> <p>Approximately 1 out of every 100 individuals has some form of venous insufficiency, which can lead to chronic venous disease and Venous Leg Ulcer (VLU). There are known underlying pathologies which contribute to the chronic nature of VLU including biofilm phenotype infections.</p> <p>Results</p> <p>Using pyrosequencing based approaches we evaluated VLU to characterize their microbial ecology. Results show that VLU infections are polymicrobial with no single bacterium colonizing the wounds. The most ubiquitous and predominant organisms include a previously uncharacterized bacteroidales, various anaerobes, <it>Staphylococcus</it>, <it>Corynebacterium</it>, and <it>Serratia</it>. Topological analysis of VLU show some notable differences in bacterial populations across the surface of the wounds highlighting the importance of sampling techniques during diagnostics. Metagenomics provide a preliminary indication that there may be protozoa, fungi and possibly an undescribed virus associated with these wounds.</p> <p>Conclusion</p> <p>The polymicrobial nature of VLU and previous research on diabetic foot ulcers and surgical site infections suggest that the future of therapy for such wounds lies in the core of the logical and proven multiple concurrent strategy approach, which has been termed "biofilm-based wound care" and the use of individualized therapeutics rather than in a single treatment modality.</p

    Comparison of Culture and Molecular Identification of Bacteria in Chronic Wounds

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    Clinical diagnostics of chronic polymicrobial infections, such as those found in chronic wounds, represent a diagnostic challenge for both culture and molecular methods. In the current retrospective study, the results of aerobic bacterial cultures and culture-free bacterial identification using DNA analyses were compared. A total of 168 chronic wounds were studied. The majority of bacteria identified with culture testing were also identified with molecular testing, but the majority of bacteria identified with the molecular testing were not identified with culture testing. Seventeen (17) different bacterial taxa were identified with culture, and 338 different bacterial taxa were identified with molecular testing. This study demonstrates the increased sensitivity that molecular microbial identification can have over culture methodologies, and previous studies suggest that molecular bacterial identification can improve the clinical outcomes of patients with chronic wounds

    Can we talk about trust? Exploring the relevance of - Entrustable Professional Activities- in dental education

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162795/2/jdd12354_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162795/1/jdd12354.pd

    We haven't got a seat on the bus for you or All the seats are mine: Narratives and career transitions in professional golf

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    In this article we explore how the stories an athlete tells throughout life in sport affect her career transition experiences. We base our enquiry on a social constructionist conception of narrative theory which holds that storytelling is integral to the creation and maintenance of identity and sense of self. Life stories were gathered through interviews with two professional women golfers (Christiana and Kandy) over a six‐year period. Through a narrative analysis of structure and form we explored each participant’s stories of living in and withdrawing from professional golf. We suggest Christiana told monological performance‐oriented stories which, while aligning with the culture of elite sport, resulted in an exclusive athletic identity and foreclosure of alternative selves and roles. On withdrawal, Christiana experienced narrative wreckage, identity collapse, mental health difficulties and considerable psychological trauma. In contrast, Kandy told dialogical discovery‐oriented stories which, while being in tension with the dominant performance narrative, created and sustained a multidimensional identity and self. Her stories and identity remained intact, authentic and continuous on withdrawal from tournament golf and she experienced few psychological problems

    Toward a Social Practice Theory of Relational Competing

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    This paper brings together the competitive dynamics and strategy-aspractice literatures to investigate relational competition. Drawing on a global ethnography of the reinsurance market, we develop the concept of micro-competitions, which are the focus of competitors’ everyday competitive practices. We find variation in relational or rivalrous competition by individual competitors across the phases of a micro-competition, between competitors within a micro-competition, and across multiple micro-competitions. These variations arise from the interplay between the unfolding competitive arena and the implementation of each firm’s strategic portfolio. We develop a conceptual framework that makes four contributions to: relational competition; reconceptualizing action and response; elaborating on the awareness-motivation-capability framework within competitive dynamics; and the recursive dynamic by which implementing strategy inside firms shapes, and is shaped by, the competitive arena

    A Comparison of Bacterial Composition in Diabetic Ulcers and Contralateral Intact Skin

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    An extensive portion of the healthcare budget is allocated to chronic human infection. Chronic wounds in particular are a major contributor to this financial burden. Little is known about the types of bacteria which may contribute to the chronicity, biofilm and overall bioburden of the wound itself. In this study we compare the bacteriology of wounds and associated intact skin. Wound and paired intact skin swabs (from a contralateral location) were collected. The bacterial diversity was determined using bacterial Tag-encoded FLX amplicon pyrosequencing (bTEFAP). Diversity analysis showed intact skin to be significantly more diverse than wounds on both the species and genus levels (3% and 5% divergence). Furthermore, wounds show heightened levels of anaerobic bacteria, like Peptoniphilus, Finegoldia, and Anaerococcus, and other detrimental genera such as Corynebacterium and Staphylococcus. Although some of these and other bacterial genera were found to be common between intact skin and wounds, notable opportunistic wound pathogens were found at lower levels in intact skin. Principal Component Analysis demonstrated a clear separability of the two groups. The findings of the study not only greatly support the hypothesis of differing bacterial composition of intact skin and wounds, but also contribute additional insight into the ecology of skin and wound microflora. The increased diversity and lowered levels of opportunistic pathogens found in skin make the system highly distinguishable from wounds
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