A mesoionic carbene complex of manganese in five oxidation states

Reaction between a carbazole-based mesoionic carbene ligand and manganese(II) iodide results in the formation of a rare air-stable manganese(IV) complex after aerobic workup. Cyclic voltammetry reveals the complex to be stable in five oxidation states. The electronic structure of all five oxidation states is elucidated chemically, spectroscopically (NMR, high-frequency EPR, UV-Vis, MCD), magnetically, and computationally (DFT, CASSCF)

A mesoionic carbene complex of manganese in five oxidation states

Reaction between a carbazole-based mesoionic carbene ligand and manganese(ii) iodide results in the formation of a rare air-stable manganese(iv) complex after aerobic workup. Cyclic voltammetry reveals the complex to be stable in five oxidation states. The electronic structure of all five oxidation states is elucidated chemically, spectroscopically (NMR, high-frequency EPR, UV-Vis, MCD), magnetically, and computationally (DFT, CASSCF).Fil: Wittwer, Benjamin. Universidad de Innsbruck; AustriaFil: Dickmann, Nicole. University of Paderborn; AlemaniaFil: Berg, Stephan. University of Paderborn; AlemaniaFil: Leitner, Daniel. Universidad de Innsbruck; AustriaFil: Tesi, Lorenzo. Universitat Stuttgart; AlemaniaFil: Hunger, David. Universitat Stuttgart; AlemaniaFil: Gratzl, Raphael. Universidad de Innsbruck; AustriaFil: van Slageren, Joris. Universitat Stuttgart; AlemaniaFil: Neuman, Nicolás Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universitat Stuttgart; AlemaniaFil: Munz, Dominik. Universitat Saarland; Alemania. Universitat Erlangen Nuremberg; AlemaniaFil: Hohloch, Stephan. Universidad de Innsbruck; Austri

Multiplexed identification, quantification and genotyping of infectious agents using a semiconductor biochip

The emergence of pathogens resistant to existing antimicrobial drugs is a growing worldwide health crisis that threatens a return to the pre-antibiotic era. To decrease the overuse of antibiotics, molecular diagnostics systems are needed that can rapidly identify pathogens in a clinical sample and determine the presence of mutations that confer drug resistance at the point of care. We developed a fully integrated, miniaturized semiconductor biochip and closed-tube detection chemistry that performs multiplex nucleic acid amplification and sequence analysis. The approach had a high dynamic range of quantification of microbial load and was able to perform comprehensive mutation analysis on up to 1,000 sequences or strands simultaneously in <2 h. We detected and quantified multiple DNA and RNA respiratory viruses in clinical samples with complete concordance to a commercially available test. We also identified 54 drug-resistance-associated mutations that were present in six genes of Mycobacterium tuberculosis, all of which were confirmed by next-generation sequencing

Low-noise transfer of the spectral purity of an optical comb line using a feedforward scheme

We present a detailed frequency noise analysis of a feedforward scheme used to faithfully transfer the spectral properties of an individual line of an optical frequency comb spectrum to a single-mode laser and in this way indirectly amplify it, which is applicable to any arbitrary comb mode spacing. In contrast to previously reported implementation of the feedforward method for a similar purpose, we present a more thorough noise study, including the measurement of the additive noise of the setup. The reported experimental investigation was performed using two low-noise ultrafast mode-locked lasers with different repetition rates (~ 1 GHz and 250 MHz) and show a faithful transfer of the comb mode frequency noise to the auxiliary laser with a sub-radian additive phase noise integrated from 1 Hz to 1 MHz. We discuss the present limitations of the method that is able to transfer optical comb lines with sub-Hz linewidth and propose simple improvements

Observation of a volatile astatine hydroxide species in online gas-adsorption thermochromatography experiments

During recent online gas-phase experiments with the transactinide elements copernicium (Cn, Z = 112) and flerovium (Fl, Z = 114), the transport of a volatile astatine species was observed. Comprehensive Monte Carlo simulations of the deposition pattern of ²¹¹At on the given quartz, selenium, and gold chromatographic surfaces were carried out, and the corresponding adsorption enthalpies were estimated. Based on the astatine speciation from previous model experiments, the compound observed in this work was ascribed to AtOH/HAtO. The herein presented results assist in paving the way toward a future chemical characterization of tennessine (Ts, Z = 117) with similar gas adsorption chromatography techniques.ISSN:0026-8976ISSN:1362-302