189 research outputs found
Epitaxial strain adaption in chemically disordered FeRh thin films
Strain and strain adaption mechanisms in modern functional materials are of
crucial importance for their performance. Understanding these mechanisms will
advance innovative approaches for material properties engineering. Here we
study the strain adaption mechanism in a thin film model system as function of
epitaxial strain. Chemically disordered FeRh thin films are deposited on W-V
buffer layers, which allow for large variation of the preset lattice constants,
e.g. epitaxial boundary condition. It is shown by means of high resolution
X-ray reciprocal space maps and transmission electron microscopy that the
system reacts with a tilting mechanism of the structural units in order to
adapt to the lattice constants of the buffer layer. This response explained by
density functional theory calculations, which evidence an energetic minimum for
structures with a distortion of c/a =0.87. The experimentally observed tilting
mechanism is induced by this energy gain and allows the system to remain in the
most favorable structure. In general, it is shown that the use of epitaxial
model heterostructures consisting of alloy buffer layers of fully miscible
elements and the functional material of interest allows to study strain
adaption behaviors in great detail. This approach makes even small secondary
effects observable, such as the directional tilting of the structural domains
identified in the present case study
Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning
For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode Caenorhabditis elegans. The proposed machine learning system is trained to recognize exons and introns on the unspliced mRNA, utilizing recent advances in support vector machines and label sequence learning. In 87% (coding and untranslated regions) and 95% (coding regions only) of all genes tested in several out-of-sample evaluations, our method correctly identified all exons and introns. Notably, only 37% and 50%, respectively, of the presently unconfirmed genes in the C. elegans genome annotation agree with our predictions, thus we hypothesize that a sizable fraction of those genes are not correctly annotated. A retrospective evaluation of the Wormbase WS120 annotation [1] of C. elegans reveals that splice form predictions on unconfirmed genes in WS120 are inaccurate in about 18% of the considered cases, while our predictions deviate from the truth only in 10%â13%. We experimentally analyzed 20 controversial genes on which our system and the annotation disagree, confirming the superiority of our predictions. While our method correctly predicted 75% of those cases, the standard annotation was never completely correct. The accuracy of our system is further corroborated by a comparison with two other recently proposed systems that can be used for splice form prediction: SNAP and ExonHunter. We conclude that the genome annotation of C. elegans and other organisms can be greatly enhanced using modern machine learning technology
Synthesis and characterisation of fluorinated epitaxial films of BaFeOF: Tailoring magnetic anisotropy: Via a lowering of tetragonal distortion
In this article, we report on the synthesis and characterisation of fluorinated epitaxial films of BaFeOF via low-temperature fluorination of thin films of BaFeO grown by pulsed laser deposition. Diffraction measurements show that fluoride incorporation only results in a contraction of the film perpendicular to the film surface, where clamping by the substrate is prohibitive for strong in-plane changes. The fluorinated films were found to be homogenous regarding the fluorine content over the whole film thickness, and can be considered as single crystal equivalents to the bulk phase BaFeOF. Surprisingly, fluorination resulted in the change of the tetragonal distortion to a nearly cubic symmetry, which results in a lowering of anisotropic orientation of the magnetic moments of the antiferromagnetically ordered compound, confirmed by MĂśssbauer spectroscopy and magnetic studies
Proton Conduction in Grain-Boundary-Free Oxygen-Deficient BaFeO Thin Films
Reduction of the operating temperature to an intermediate temperature range between 350 °C and 600 °C is a necessity for Solid Oxide Fuel/Electrolysis Cells (SOFC/SOECs). In this respect the application of proton-conducting oxides has become a broad area of research. Materials that can conduct protons and electrons at the same time, to be used as electrode catalysts on the air electrode, are especially rare. In this article we report on the proton conduction in expitaxially grown BaFeO2.5+δ (BFO) thin films deposited by pulsed laser deposition on Nb:SrTiO3 substrates. By using Electrochemical Impedance Spectroscopy (EIS) measurements under different wet and dry atmospheres, the bulk proton conductivity of BFO (between 200 °C and 300 °C) could be estimated for the first time (3.6 Ă 10â6 S cmâ1 at 300 °C). The influence of oxidizing measurement atmosphere and hydration revealed a strong dependence of the conductivity, most notably at temperatures above 300 °C, which is in good agreement with the hydration behavior of BaFeO2.5 reported previously
tumor atelectasis gives rise to a solid appearance in pulmonary adenocarcinomas on hr ct
Abstract Introduction Ground glass opacities on HR-CT scan, if malignant on histological examination, correlate with adenocarcinoma in situ. Solid appearance on HR-CT is often considered an invasive component. This study aims to compare radiological features on HR-CT and histological features of primary adenocarcinomas in resection specimens in order to demonstrate the presence of tumor atelectasis in ground glass nodules, part solid and solid nodules. Materials and Methods HR-CT imaging was evaluated, and lung nodules were classified as ground glass nodule, part solid nodule and solid nodule, while adenocarcinomas were classified according to WHO classification. Lepidic growth pattern with collapse was considered if reduction of air in the histological section was present, with maintained pulmonary architecture (without signs of pleural or vascular invasion). Results Radiological and histological features were compared in 47 lesions of 41 patients. The number of ground glass, part solid and solid nodules were 2, 8 and 37, respectively. Lepidic growth pattern with collapse was observed in both ground glass nodules, 7 out of 8 (88%) part solid and 24 out of 37 (65%) solid lesions. Remarkably, more than 50% of adenocarcinomas with solid appearance on HR-CT showed a pre-existing pulmonary architecture with adenocarcinoma with a predominant lepidic growth pattern. In these cases, the solid component can be explained by tumor related collapse in vivo (tumor atelectasis on radiology). Conclusion Tumor atelectasis is a frequent finding in pulmonary adenocarcinomas and results in solid appearance on HR-CT. A solid appearance on HR-CT can not only be attributed to invasion, as has been the assumption until now
Techniques for Galactic Dust Measurements in the Heliosphere
Galactic interstellar dust (ISD) is the major ingredient in planetary
formation. However, information on this important material has been extremely
limited. Recently the Ulysses dust detector has identified and measured
interstellar dust outside 1.8~AU from the Sun at ecliptic latitudes above
. Inside this distance it could not reliably distinguish
interstellar from interplanetary dust. Modeling the Ulysses data suggests that
up to 30 % of dust flux with masses above at 1~AU is of
interstellar origin. From the Hiten satellite in high eccentric orbit about the
Earth there are indications that ISD indeed reaches the Earth's orbit. Two new
missions carrying dust detectors, Cassini and Stardust, will greatly increase
our observational knowledge. In this paper we briefly review instruments used
on these missions and compare their capabilities. The Stardust mission [{\em
Brownlee et al.}, 1996] will analyze the local interstellar dust population by
an in-situ chemical analyzer and collect ISD between 2 and 3~AU from the Sun.
The dust analyzer on the Cassini mission will determine the interstellar dust
flux outside Venus' orbit and will provide also some compositional information.
Techniques to identify the ISD flux levels at 1~AU are described that can
quantify the interstellar dust flux in high-Earth orbit (outside the debris
belts) and provide chemical composition information of galactic dust.Comment: Accepted for Journal of Geophysical Research, 6 figures, Late
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