33 research outputs found
Random walks and polymers in the presence of quenched disorder
After a general introduction to the field, we describe some recent results
concerning disorder effects on both `random walk models', where the random walk
is a dynamical process generated by local transition rules, and on `polymer
models', where each random walk trajectory representing the configuration of a
polymer chain is associated to a global Boltzmann weight. For random walk
models, we explain, on the specific examples of the Sinai model and of the trap
model, how disorder induces anomalous diffusion, aging behaviours and Golosov
localization, and how these properties can be understood via a strong disorder
renormalization approach. For polymer models, we discuss the critical
properties of various delocalization transitions involving random polymers. We
first summarize some recent progresses in the general theory of random critical
points : thermodynamic observables are not self-averaging at criticality
whenever disorder is relevant, and this lack of self-averaging is directly
related to the probability distribution of pseudo-critical temperatures
over the ensemble of samples of size . We describe the
results of this analysis for the bidimensional wetting and for the
Poland-Scheraga model of DNA denaturation.Comment: 17 pages, Conference Proceedings "Mathematics and Physics", I.H.E.S.,
France, November 200
Splenectomy for splenomegaly and secondary hypersplenism
Splenomegaly and secondary hypersplenism may be associated with acute and chronic infections, autoimmune states, portal hypertension or splenic vein thrombosis, and a number of infiltrative and neoplastic conditions involving the spleen. Our experience and that of others with these various conditions demonstrates that the decision to perform splenectomy should be based on well-defined and often strictly limited indications. Except for idiopathic splenomegaly, the presence and severity of secondary hypersplenism or severely symptomatic splenomegaly should be well documented. In each case, the potential for palliation and known mean duration of expected response must be weighed against the increased morbidity and mortality of splenectomy (as compared to operation for “primary” hypersplenism) . La splĂ©nomĂ©galie avec hypersplĂ©nisme secondaire relève de multiples causes: infection aigue ou chronique, Ă©tats autoimmunologiques, hypertension portale, thrombose de la veine splĂ©nique, lĂ©sions tumorales splĂ©niques. L'expĂ©rience de l'auteur qui rejoint celle de nombreux collègues lui permet d'affirmer que les indications de la splĂ©nectomie doivent ĂŞtre bien dĂ©finies et sont strictement limitĂ©es. A l'exception de la splĂ©nomĂ©galie idiopathique, l'existence et l'intensitĂ© de l'hypersplĂ©nisme, l'importance des symptomes provoquĂ©s par la splĂ©nomĂ©galie doivent ĂŞtre aprrĂ©ciĂ©es avec prĂ©cision. Dans chaque cas le potentiel de la rĂ©mission de l'affection et la durĂ©e de la rĂ©mission doivent ĂŞtre pris en considĂ©ration en fonction de l'Ă©ventuelle morbiditĂ© et de l'Ă©ventuelle mortalitĂ© de la splĂ©nectomie (par comparaison avec la splĂ©nectomie pour hypersplĂ©nisme primaire). Eplenomegalia e hiperesplenismo secundario pueden estar asociados con infecciones agudas y crĂłnicas, estados autoinmunes (sĂndrome de Felty, lupus eritematoso sistĂ©mico), “esplenomegalia congestiva” por hipertensiĂłn portal o trombosis de la vena esplĂ©nica y con una variedad de entidades de tipo infiltrativo y neoplásico que afectan al bazo (sarcoidosis, enfermedad de Gaucher, varios desĂłrdenes mieloproliferativos y linfomas). Nuestra experiencia, y aquella de otros autores, con tales condiciones demuestra que la decisiĂłn de realizar esplenectomĂa debe estar fundamentada en indicaciones bien definidas y estrictamente limitadas. Excepto en casos de esplenomegalia idiopática, la presencia y severidad del hiperesplenismo secundario o de esplenomegalia severamente sintomática debe ser bien documentada. En cada caso debe determinarse el potencial de paliaciĂłn y la duraciĂłn de la respuesta que se espera obtener frente a la incrementada morbilidad y mortalidad de la esplenectomĂa (en comparaciĂłn con la operaciĂłn que se realiza por hiperesplenismo “primario”).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41318/1/268_2005_Article_BF01655279.pd
Antioestrogens and breast cancer Tamoxifen resistance and the effects of pure antioestrogens on cell proliferation and gene expression
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A low-cost, Nist-traceable, high performance dielectric resonator Master Oscillator
The current CEBAF Master Oscillator (MO) uses a quartz-based 10 MHz reference to synthesize 70 MHz and 499 MHz, which are then distributed to each of the klystron galleries on site. Due to the specialized nature of CEBAF's MO requirements, it has been determined that an in-house design and fabrication would provide a cost-effective alternative to purchasing or modifying vendor equipment. A Global Positioning System (GPS) disciplined, Direct Digital Synthesis (DDS) based MO is proposed which incorporates low-cost consumer RF components, designed for cellular communications. A 499 MHz Dielectric Resonant Oscillator (DRO) Voltage Controlled Oscillator (VCO) is phase-locked to a GPS-disciplined 10 MHz reference, and micro-tuned via a DDS, in an effort to achieve the lowest phase noise possible
The uptake of amino acids by isolated segments of rat intestine II. A survey of affinity for uptake from rates of uptake and competition for uptake
Liver transplantation after radioembolization in a patient with unresectable HCC
Background. A 58-year-old white man who was being followed by his hepatologist for nonalcoholic steatohepatitis-related liver cirrhosis and portal hypertension and who had been found to have a biopsy-proven hepatocellular carcinoma (HCC) on routine screening, self-referred to our center for a second opinion on the management of his HCC. Investigations. Laboratory investigations, CT scan of the abdomen and chest, bone scan and technetium macroaggregated albumin scan. Diagnosis. The patient had unresectable HCC. Management. The patient underwent two treatments with Yttrium-90 glass microspheres, which were performed as outpatient procedures 1 month and 3 months after diagnosis. He underwent orthotopic liver transplantation (OLT) 1 year after the initial diagnosis of HCC. The post-OLT immunoregimen included OKT3 plus rituximab and high-dose steroids. On discharge from hospital he was on immunosuppressive treatment with tacrolimus. He had de novo autoimmune hepatitis 6 months post-OLT, which was treated with a short course of low-dose steroids and addition of mycophenolate mofetil
Executive Incentive Schemes in Initial Public Offerings: The Effects of Multiple-Agency Conflicts and Corporate Governance
Combining a behavioral agency perspective with research on multiple-agency conflicts, this article examines factors affecting the implementation of equity-based incentive schemes in initial public offerings (IPOs). With a unique sample of U.K. IPO companies between the years 1998 and 2002, it shows that conditional (performance-related) incentive schemes are negatively associated with share ownership and board power of the IPO’s founding directors. However, the retained ownership of venture capital firms is positively associated with the probability of conditional incentive schemes. Board independence weakly effects on the toughness of executive compensation. The article’s interesting findings suggest a number of avenues for a future analysis of the governance development process in threshold firms