Herramientas para la toma de decisiones en la planificación financiera de la jubilación

La desfavorable evolución de las variables demográficas y económicas supone una agravación de la sostenibilidad del sistema público de pensiones español, lo cual también dificulta poder mantener la suficiencia de las pensiones públicas para la jubilación. En consecuencia, los trabajadores se plantean invertir en instrumentos de ahorro privado para complementar la pensión pública y así garantizar la suficiencia de ingresos en el momento de la jubilación. El trabajo plantea herramientas alternativas para seleccionar el producto de ahorro para la jubilación más conveniente. Estas herramientas se basan en el uso del operador linguistic ordered weighted averaging (LOWA), el operador induced linguistic ordered weighted averaging (ILOWA), el operador linguistic ordered weighted averaging distance (LOWAD) y el operador linguistic induced ordered weighted averaging distance (LIOWAD). Al final del trabajo, se presenta un ejemplo ilustrativo de la aplicación de los operadores de agregación LOWA, ILOWA, LOWAD y LIOWAD en procesos de planificación financiera para la jubilación. Los resultados demuestran la utilidad de esta clase de operadores de agregación lingüísticos en la toma de decisiones para la jubilación

Designing Bioactive Delivery Systems for Tissue Regeneration

The direct infusion of macromolecules into defect sites generally does not impart adequate physiological responses. Without the protection of delivery systems, inductive molecules may likely redistribute away from their desired locale and are vulnerable to degradation. In order to achieve efficacy, large doses supplied at interval time periods are necessary, often at great expense and ensuing detrimental side effects. The selection of a delivery system plays an important role in the rate of re-growth and functionality of regenerating tissue: not only do the release kinetics of inductive molecules and their consequent bioactivities need to be considered, but also how the delivery system interacts and integrates with its surrounding host environment. In the current review, we describe the means of release of macromolecules from hydrogels, polymeric microspheres, and porous scaffolds along with the selection and utilization of bioactive delivery systems in a variety of tissue-engineering strategies

Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects

Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development