Sport for development and transformative social change: The potential of Margaret Archer’s Morphogenetic Approach to reconceptualise a longstanding problem

Frequent calls for sport-for-development (SfD) to be re-oriented towards transformative social change reflect the extent that policies and programmes have instead focused on individualised forms of personal development. However, SfD research has yet to substantially address fundamental ontological assumptions and underlying conceptualisations of transformative social change. To addresses this gap, we consider how Margaret Archer’s Morphogenetic Approach can help explain how transformative social change might occur through SfD activities. Three conceptual contributions are brought into focus: (1) assuming a realist social ontology, (2) making distinctions between structure, culture and agency, and (3) identifying social change as happening across three temporal phases. We conclude by identifying potential benefits and implications of applying the Morphogenetic Approach to consider the potential for SfD to contribute to social change

Elizabeth Gaskell and Romanticism : the romantic inheritance and her shorter works

The purpose of this thesis is to investigate the relationship between Elizabeth Gaskelland Romanticism, as shown in her shorter works. This investigation will beconducted in three principal ways: a consideration of Romanticism as a culturalphenomenon; a discussion of the cultural environment in which Gaskell was nurtured;and a critical appraisal of a selection of her shorter works. The first chapter is aconsideration and discussion of Romanticism as a cultural shift which manifesteditself through the closing decades of the eighteenth century and the early decades ofthe nineteenth century. Aspects of this cultural shift considered include literature,music and the visual arts. The second chapter focuses on biographical considerationswith particular reference to Elizabeth Gaskell's family circumstances and the kind ofeducation to which she had access. The remaining chapters offer a detailed discussionof a representative selection of her shorter works. These texts have been chosen toreveal her early collaboration with her husband William Gaskell; her knowledge ofRomantic poets; and ways in which she developed as a writer. This developmentshows an engagement with an increasingly wide range of Romantic poets and awillingness on her part to engage with the darker side of Romanticism, especiallythrough the use of Gothic techniques. The focus is on Gaskell's shorter worksbecause these texts have received far less critical attention than her full-length novelsand because of her contribution to the rise of the modem short story, as a genredistinct from the novel

Comparative analysis of haplotype association mapping algorithms

BACKGROUND: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross between two strains with substantially different phenotype and an interval mapping method to compute confidence intervals at each position in the genome. This process requires significant resources for breeding and genotyping, and the data generated are usually only applicable to one phenotype of interest. Recently, we reported the application of a haplotype association mapping method which utilizes dense genotyping data across a diverse panel of inbred mouse strains and a marker association algorithm that is independent of any specific phenotype. As the availability of genotyping data grows in size and density, analysis of these haplotype association mapping methods should be of increasing value to the statistical genetics community. RESULTS: We describe a detailed comparative analysis of variations on our marker association method. In particular, we describe the use of inferred haplotypes from adjacent SNPs, parametric and nonparametric statistics, and control of multiple testing error. These results show that nonparametric methods are slightly better in the test cases we study, although the choice of test statistic may often be dependent on the specific phenotype and haplotype structure being studied. The use of multi-SNP windows to infer local haplotype structure is critical to the use of a diverse panel of inbred strains for QTL mapping. Finally, because the marginal effect of any single gene in a complex disease is often relatively small, these methods require the use of sensitive methods for controlling family-wise error. We also report our initial application of this method to phenotypes cataloged in the Mouse Phenome Database. CONCLUSION: The use of inbred strains of mice for QTL mapping has many advantages over traditional methods. However, there are also limitations in comparison to the traditional linkage analysis from F2 and RI lines. Application of these methods requires careful consideration of algorithmic choices based on both theoretical and practical factors. Our findings suggest general guidelines, though a complete evaluation of these methods can only be performed as more genetic data in complex diseases becomes available

Cosmology, cohomology, and compactification

Ashtekar and Samuel have shown that Bianchi cosmological models with compact spatial sections must be of Bianchi class A. Motivated by general results on the symmetry reduction of variational principles, we show how to extend the Ashtekar-Samuel results to the setting of weakly locally homogeneous spaces as defined, e.g., by Singer and Thurston. In particular, it is shown that any m-dimensional homogeneous space G/K admitting a G-invariant volume form will allow a compact discrete quotient only if the Lie algebra cohomology of G relative to K is non-vanishing at degree m.Comment: 6 pages, LaTe

Detailed balance in Horava-Lifshitz gravity

We study Horava-Lifshitz gravity in the presence of a scalar field. When the detailed balance condition is implemented, a new term in the gravitational sector is added in order to maintain ultraviolet stability. The four-dimensional theory is of a scalar-tensor type with a positive cosmological constant and gravity is nonminimally coupled with the scalar and its gradient terms. The scalar field has a double-well potential and, if required to play the role of the inflation, can produce a scale-invariant spectrum. The total action is rather complicated and there is no analog of the Einstein frame where Lorentz invariance is recovered in the infrared. For these reasons it may be necessary to abandon detailed balance. We comment on open problems and future directions in anisotropic critical models of gravity.Comment: 10 pages. v2: discussion expanded and improved, section on generalizations added, typos corrected, references added, conclusions unchange

A rotating three component perfect fluid source and its junction with empty space-time

The Kerr solution for empty space-time is presented in an ellipsoidally symmetric coordinate system and it is used to produce generalised ellipsoidal metrics appropriate for the generation of rotating interior solutions of Einstein's equations. It is shown that these solutions are the familiar static perfect fluid cases commonly derived in curvature coordinates but now endowed with rotation. The resulting solutions are also discussed in the context of T-solutions of Einstein's equations and the vacuum T-solution outside a rotating source is presented. The interior source for these solutions is shown not to be a perfect fluid but rather an anisotropic three component perfect fluid for which the energy momentum tensor is derived. The Schwarzschild interior solution is given as an example of the approach.Comment: 14 page

Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action

Components of the mitochondrial electron transport chain have recently gained much interest as potential therapeutic targets. Since mitochondria are essential for the supply of energy that is required for both angiogenic and tumourigenic activity, targeting the mitochondria represents a promising potential therapeutic approach for treating cancer. Here we investigate the established anti-angiogenesis drugs combretastatin A4, thalidomide, OGT 2115 and tranilast that we hypothesise are able to exert a direct anti-cancer effect in the absence of vasculature by targeting the mitochondria. Drug cytotoxicity was measured using the MTT assay. Mitochondrial function was measured in intact isolated mitochondria using polarography, fluorimetry and enzymatic assays to measure mitochondrial oxygen consumption, membrane potential and complex I–IV activities respectively. Combretastatin A4, OGT 2115 and tranilast were both shown to decrease mitochondrial oxygen consumption. OGT 2115 and tranilast decreased mitochondrial membrane potential and reduced complex I activity while combretastatin A4 and thalidomide did not. OGT 2115 inhibited mitochondrial complex II–III activity while combretastatin A4, thalidomide and tranilast did not. Combretastatin A4, thalidomide and OGT 2115 induced bi-phasic concentration-dependent increases and decreases in mitochondrial complex IV activity while tranilast had no evident effect. These data demonstrate that combretastatin A4, thalidomide, OGT 2115 and tranilast are all mitochondrial modulators. OGT 2115 and tranilast are both mitochondrial inhibitors capable of eliciting concentration-dependent reductions in cell viability by decreasing mitochondrial membrane potential and oxygen consumption

A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior

Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a approximately 475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390-30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various outbred and wild-caught mice. Presence of the duplication is associated with a cis-acting expression QTL for Glo1 (LOD>30) in BXD recombinant inbred strains. However, evidence for an eQTL for Glo1 was not obtained when we analyzed single SNPs or 3-SNP haplotypes in a panel of 27 inbred strains. We conclude that association analysis in the inbred strain panel failed to detect an eQTL because the duplication was present on multiple highly divergent haplotypes. Furthermore, we suggest that non-allelic homologous recombination has led to multiple reversions to the non-duplicated state among inbred strains. We show associations between multiple duplication-containing haplotypes, Glo1 expression and anxiety-like behavior in both inbred strain panels and outbred CD-1 mice. Our findings provide a molecular basis for differential expression of Glo1 and further implicate Glo1 in anxiety-like behavior. More broadly, these results identify problems with commonly employed tests for association in inbred strains when CNVs are present. Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs.These studies were funded by MH070933, MH79103 and MH020065

Entropy of Lovelock Black Holes

A general formula for the entropy of stationary black holes in Lovelock gravity theories is obtained by integrating the first law of black hole mechanics, which is derived by Hamiltonian methods. The entropy is not simply one quarter of the surface area of the horizon, but also includes a sum of intrinsic curvature invariants integrated over a cross section of the horizon.Comment: 15 pages, plain Latex, NSF-ITP-93-4